Science | Nature | Cell | View More
Natural Products
3-O-Caffeoylquinic acid methyl ester
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 3-O-Caffeoylquinic acid methyl ester
Price: $268 / 20mg
CAS No.: 123483-19-2
Catalog No.: CFN92573
Molecular Formula: C17H20O9
Molecular Weight: 368.3 g/mol
Purity: >=98%
Type of Compound: Phenylpropanoids
Physical Desc.: Powder
Source: The fruits of Morus alba L
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $49.6 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of Sao Paulo (Brazil)
  • Ateneo de Manila University (Philippines)
  • Kyung Hee University (Korea)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Almansora University (Egypt)
  • Michigan State University (USA)
  • Mendel University in Brno (Czech Republic)
  • Universit?t Basel (Switzerland)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • University of Parma (Italy)
  • Seoul National University (Korea)
  • More...
Package
Featured Products
Isochlorogenic acid B

Catalog No: CFN99119
CAS No: 14534-61-3
Price: $50/20mg
gamma-Mangostin

Catalog No: CFN98396
CAS No: 31271-07-5
Price: $70/20mg
8-Hydroxypinoresinol

Catalog No: CFN92432
CAS No: 81426-17-7
Price: $ / mg
Catechin

Catalog No: CFN99646
CAS No: 154-23-4
Price: $30/20mg
Polyphyllin II

Catalog No: CFN99953
CAS No: 76296-72-5
Price: $/mg
Luteolin-3-O-beta-D-glucuronide

Catalog No: CFN93187
CAS No: 53527-42-7
Price: $238/10mg
Neochamaejasmine A

Catalog No: CFN92151
CAS No: 90411-13-5
Price: $418/5mg
Pinoresinol

Catalog No: CFN98775
CAS No: 487-36-5
Price: $188/20mg
Eupatorin

Catalog No: CFN97418
CAS No: 855-96-9
Price: $158/10mg
Piperine

Catalog No: CFN99919
CAS No: 94-62-2
Price: $30/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 3-O-Caffeoylquinic acid methyl ester is a natural product from Morus alba L.
In vitro:
Planta Med. 2004 Aug;70(8):711-7.
Inhibiting activities of the secondary metabolites of Phlomis brunneogaleata against parasitic protozoa and plasmodial enoyl-ACP Reductase, a crucial enzyme in fatty acid biosynthesis.[Pubmed: 15326547 ]
Anti-plasmodial activity-guided fractionation of Phlomis brunneogaleata (Lamiaceae) led to the isolation of two new metabolites, the iridoid glycoside, brunneogaleatoside and a new pyrrolidinium derivative (2 S,4 R)-2-carboxy-4-( E)- p-coumaroyloxy-1,1-dimethylpyrrolidinium inner salt [(2 S,4 R)-1,1-dimethyl-4-( E)- p-coumaroyloxyproline inner salt]. Moreover, a known iridoid glycoside, ipolamiide, six known phenylethanoid glycosides, verbascoside, isoverbascoside, forsythoside B, echinacoside, glucopyranosyl-(1-->G (i)-6)-martynoside and integrifolioside B, two flavone glycosides, luteolin 7- O-beta- D-glucopyranoside ( 10) and chrysoeriol 7- O-beta- D-glucopyranoside ( 11), a lignan glycoside liriodendrin, an acetophenone glycoside 4-hydroxyacetophenone 4- O-(6'- O-beta- D-apiofuranosyl)-beta- D-glucopyranoside and three caffeic acid esters, chlorogenic acid, 3-O-Caffeoylquinic acid methyl ester and 5- O-caffeoylshikimic acid were isolated.
METHODS AND RESULTS:
The structures of the pure compounds were elucidated by means of spectroscopic methods (UV, IR, MS, 1D and 2D NMR, [alpha] (D)) and X-ray crystallography. Compounds 10 and 11 were determined to be the major anti-malarial principles of the crude extract (IC (50) values of 2.4 and 5.9 micrograms/mL, respectively). They also exhibited significant leishmanicidal activity (IC (50) = 1.1 and 4.1 micrograms/mL, respectively). The inhibitory potential of the pure metabolites against plasmodial enoyl-ACP reductase (FabI), which is the key regulator of type II fatty acid synthases (FAS-II) in P. falciparum, was also assessed.
CONCLUSIONS:
Compound 10 showed promising FabI inhibiting effect (IC (50) = 10 micrograms/mL) and appears to be the first anti-malarial natural product targeting FabI of P. falciparum.
3-O-Caffeoylquinic acid methyl ester Description
Source: The fruits of Morus alba L
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
New compound 9

Catalog No: CFN95342
CAS No: N/A
Price: $413/5mg
Bocconoline

Catalog No: CFN95373
CAS No: 32906-88-0
Price: $413/5mg
Lucidenic acid D2

Catalog No: CFN95020
CAS No: 98665-16-8
Price: $268/5mg
ent-16beta,17-dihydroxy-9(11)-kaur...

Catalog No: CFN95172
CAS No: 55483-24-4
Price: $318/10mg
Clemastanin B

Catalog No: CFN95064
CAS No: 112747-98-5
Price: $368/20mg
1-Methyl-2,8-dihydroxy-3-carboxy-9...

Catalog No: CFN95101
CAS No: 1401414-53-6
Price: $338/5mg
Carasinol D

Catalog No: CFN95044
CAS No: 1072797-66-0
Price: $333/5mg
3,7,23,24-tetrahydroxycucurbita-5,...

Catalog No: CFN95168
CAS No: 1446447-97-7
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.7152 mL 13.5759 mL 27.1518 mL 54.3036 mL 67.8794 mL
5 mM 0.543 mL 2.7152 mL 5.4304 mL 10.8607 mL 13.5759 mL
10 mM 0.2715 mL 1.3576 mL 2.7152 mL 5.4304 mL 6.7879 mL
50 mM 0.0543 mL 0.2715 mL 0.543 mL 1.0861 mL 1.3576 mL
100 mM 0.0272 mL 0.1358 mL 0.2715 mL 0.543 mL 0.6788 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Yao Xue Xue Bao. 2014 Apr;49(4):504-6.
Studies on chemical constituents from fruits of Morus alba L.[Pubmed: 24974468]
Chemical investigation of fruits of Mours alba L. lead to the isolation of fifteen compounds by various chromatographies such as silica gel, Sephadex LH-20, RP-C18 column chromatography.
METHODS AND RESULTS:
Their structures were determined to be: 1-[5-(2-formlfuryl) methyl] dihydrogen 2-hydroxypropane-1, 2, 3-tricarboxylate 2, 3-diethyl ester (1), 1-[2-(furan-2-yl)-2-oxoethyl] pyrrolidin-2-one (2), divaricataester A (3), methyl 1-[2-(furan-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carboxylate (4), 1-[2-(furan-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carboxylic acid (5), L-pyroglutamic acid (6), L-pyroglutamic acid ethyl ester (7), 3-O-Caffeoylquinic acid methyl ester (8), 3-O-caffeoylquinic acid ethyl ester (9), 5-O-caffeoylquinic acid methyl ester (10), 5-O-caffeoylquinic acid ethyl ester (11), 4-O-caffeoylquinic acid methyl ester (12), 4-O-caffeoylquinic acid methyl ester (13), 4-O-caffeoylquinic acid (14), 3-O-caffeoylquinic acid (15), respectively, based on the spectral analysis such as NMR, MS etc.
CONCLUSIONS:
Compounds 1-14 were isolated from this genus for the first time, among which 1 was a new compound.
Isochlorogenic acid B

Catalog No: CFN99119
CAS No: 14534-61-3
Price: $50/20mg
gamma-Mangostin

Catalog No: CFN98396
CAS No: 31271-07-5
Price: $70/20mg
8-Hydroxypinoresinol

Catalog No: CFN92432
CAS No: 81426-17-7
Price: $ / mg
Catechin

Catalog No: CFN99646
CAS No: 154-23-4
Price: $30/20mg
Polyphyllin II

Catalog No: CFN99953
CAS No: 76296-72-5
Price: $/mg
Luteolin-3-O-beta-D-glucuronide

Catalog No: CFN93187
CAS No: 53527-42-7
Price: $238/10mg
Neochamaejasmine A

Catalog No: CFN92151
CAS No: 90411-13-5
Price: $418/5mg
Pinoresinol

Catalog No: CFN98775
CAS No: 487-36-5
Price: $188/20mg
Eupatorin

Catalog No: CFN97418
CAS No: 855-96-9
Price: $158/10mg
Piperine

Catalog No: CFN99919
CAS No: 94-62-2
Price: $30/20mg
Tags: buy 3-O-Caffeoylquinic acid methyl ester | 3-O-Caffeoylquinic acid methyl ester supplier | purchase 3-O-Caffeoylquinic acid methyl ester | 3-O-Caffeoylquinic acid methyl ester cost | 3-O-Caffeoylquinic acid methyl ester manufacturer | order 3-O-Caffeoylquinic acid methyl ester | 3-O-Caffeoylquinic acid methyl ester distributor