| Structure Identification: |
| Acta Crystallogr Sect E Struct Rep Online. 2010 May 15;66(Pt 6):o1342. | | 3-Deoxyaconitine from the root of Aconitum Carmichaeli Debx.[Pubmed: 21579431] |
METHODS AND RESULTS:
3-Deoxyaconitine:8β-acet-oxy-14α-benzo-yloxy-N-ethyl-13β,15α-dihydr-oxy-1α,6α,16β-trimeth-oxy-4β-methoxy-methyl-eneaconitane), C(34)H(47)NO(10), is a typical aconitine-type C(19)-diterpenoid alkaloid, and was isolated from the roots of the Aconitum carmichaeli Debx. The mol-ecule has an aconitine carbon skeleton with four six-membered rings and two five-membered rings, whose geometry is similar to these observed in other C(19)-diterpenoid alkaloids; both of five-membered rings have the envelope configurations and the six-membered N-containing heterocyclic ring displays a chair conformation. Intra-molecular O-H⋯O hydrogen bonding occurs.
CONCLUSIONS:
Weak inter-molecular C-H⋯O hydrogen bonding is observed in the crystal structure. | | Chinese Traditional Patent Medicine , 2011 , 33 (3) :479-482. | | Determination of aconitine and 3-deoxyaconitine in fried samples of Aconitum pendulum Busch by HPLC[Reference: WebLink] | To analyze the influences on the contents of aconitine and 3-Deoxyaconitine in Aconitum pendulum Busch by different processing methods used in Tibetan medicine,Qiang medicine and Hui medicine,and to observe the relativity between processing and toxicity.
METHODS AND RESULTS:
The determination was performed by HPLC,and Kromasil C18 column(250 mm×4.6 mm,5 μm) was used with the mobile phase being methanol:water:trieth-ylamine(95:5:0.3),flow rate was 1.0 mL/min,the column temperature was set at 25 ℃,detection wave-length was set at 235 nm.All the contents of aconitine and 3-Deoxyaconitine in A.pendulum Busch samples decreased after being fried.It showed that temperature was the main factor in decomposing the dibasic acid structures of aconitine and reducing toxicity.
CONCLUSIONS:
All chromatograph peaks could be well separated,and the method is very stable.And among all the methods,the processing used in Tibetan medicine is much more scientific and effective. |
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