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7,8-Benzoflavone
7,8-Benzoflavone
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 7,8-Benzoflavone
Price: $40 / 20mg
CAS No.: 604-59-1
Catalog No.: CFN94465
Molecular Formula: C19H12O2
Molecular Weight: 272.30 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The root exudates of Acroptilon repens.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $8.9 / In-stock
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: 7,8-Benzoflavone is one of the most potent inhibitors of breast cancer resistance protein (BCRP).
In vivo:
J Pharm Sci. 2008 Oct;97(10):4546-56.
Pharmacokinetics and bioavailability of the flavonoid 7,8-benzoflavone in rats.[Pubmed: 18257033 ]
The flavonoid 7,8-Benzoflavone was recently identified as one of the most potent inhibitors of breast cancer resistance protein (BCRP); however, little is known of the in vivo disposition of 7,8-Benzoflavone. The objective of this study was to investigate the pharmacokinetics and bioavailability of 7,8-Benzoflavone in rats.
METHODS AND RESULTS:
Three intravenous (5, 10, and 25 mg/kg) and three oral (12.5, 25, and 50 mg/kg) doses were administered to female Sprague-Dawley rats. Plasma samples were analyzed by high-performance liquid chromatography. Pharmacokinetic analysis was conducted by WinNonlin and ADAPT II. The dose-normalized plasma concentration versus time curves did not superimpose with each other, indicating the nonlinear pharmacokinetics of 7,8-Benzoflavone. 7,8-Benzoflavone exhibited a large volume of distribution (V(ss) approximately 1.5 L/kg) and rapid oral absorption (t(max) < 30 min). The bioavailability of 7,8-Benzoflavone was low (0.61-13.2%) and dose-dependent. A pharmacokinetic model with dose-dependent bioavailability, linear absorption and nonlinear elimination best described the pharmacokinetic profiles of 7,8-Benzoflavone.
CONCLUSIONS:
Using a 50 mg/kg oral dose of 7,8-Benzoflavone, we could significantly increase the AUC for the BCRP substrate nitrofurantoin, demonstrating the potential for BCRP-mediated drug interactions.
7,8-Benzoflavone Description
Source: The root exudates of Acroptilon repens.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

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Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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IF=13.903(2019)

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Nature Plants. 2016 Dec 22;3: 16206.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.6724 mL 18.3621 mL 36.7242 mL 73.4484 mL 91.8105 mL
5 mM 0.7345 mL 3.6724 mL 7.3448 mL 14.6897 mL 18.3621 mL
10 mM 0.3672 mL 1.8362 mL 3.6724 mL 7.3448 mL 9.1811 mL
50 mM 0.0734 mL 0.3672 mL 0.7345 mL 1.469 mL 1.8362 mL
100 mM 0.0367 mL 0.1836 mL 0.3672 mL 0.7345 mL 0.9181 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Dipterocarpol

Catalog No: CFN98705
CAS No: 471-69-2
Price: $ /
Polyporenic acid C

Catalog No: CFN92739
CAS No: 465-18-9
Price: $268/10mg
Myricanol

Catalog No: CFN98430
CAS No: 33606-81-4
Price: $ /
Glycyrin

Catalog No: CFN89404
CAS No: 66056-18-6
Price: $368/5mg
Acteoside

Catalog No: CFN97048
CAS No: 61276-17-3
Price: $60/20mg
6beta-Hydroxystigmast-4-en-3-one

Catalog No: CFN98496
CAS No: 36450-02-9
Price: $ /
Forsythoside A

Catalog No: CFN99705
CAS No: 79916-77-1
Price: $50/20mg
Momordicoside K

Catalog No: CFN92305
CAS No: 81348-84-7
Price: $ / mg
Oxyresveratrol

Catalog No: CFN98368
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Price: $30/20mg
Isocorynoxeine

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