Science | Nature | Cell | View More
Natural Products
Alpha-pinene
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Alpha-pinene
Price: $30 / 20mg
CAS No.: 80-56-8
Catalog No.: CFN93285
Molecular Formula: C10H16
Molecular Weight: 136.2 g/mol
Purity: >=98%
Type of Compound: Monoterpenoids
Physical Desc.: Oil
Source: The heartwoods of Pinus armandii Franch.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $7.0 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of Minnesota (USA)
  • The Institute of Cancer Research (United Kingdom)
  • University of Illinois (USA)
  • China Medical University (Taiwan)
  • Chulalongkorn University (Thailand)
  • Michigan State University (USA)
  • Semmelweis Unicersity (Hungary)
  • The Australian National University (Australia)
  • University of Maryland School o... (USA)
  • University of Hertfordshire (United Kingdom)
  • University of Virginia (USA)
  • More...
Package
Featured Products
Ganoderol B

Catalog No: CFN99064
CAS No: 104700-96-1
Price: $318/5mg
Gancaonin N

Catalog No: CFN95066
CAS No: 129145-52-4
Price: $463/5mg
11-Hydroxy-sugiol

Catalog No: CFN90366
CAS No: 88664-08-8
Price: $490/5mg
8-Prenylkaempferol

Catalog No: CFN92346
CAS No: 28610-31-3
Price: $ / mg
Cimifugin

Catalog No: CFN98612
CAS No: 37921-38-3
Price: $60/20mg
Alloisoimperatorin

Catalog No: CFN95012
CAS No: 35214-83-6
Price: $338/5mg
Jujuboside A

Catalog No: CFN98101
CAS No: 55466-04-1
Price: $70/20mg
Isosinensetin

Catalog No: CFN90806
CAS No: 17290-70-9
Price: $218/20mg
Mulberroside A

Catalog No: CFN99586
CAS No: 102841-42-9
Price: $60/20mg
Geniposidic acid

Catalog No: CFN98337
CAS No: 27741-01-1
Price: $30/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Alpha-pinene inhibits the nuclear translocation of NF-kappa B induced by LPS in THP-1 cells, and this effect is partly due to the upregulation of I kappa B alpha expression. Alpha-pinene inhibits early root growth and causes oxidative damage in root tissue through enhanced generation of ROS, as indicated by increased lipid peroxidation, disruption of membrane integrity and elevated antioxidant enzyme levels.
Targets: NF-kB | p65 | ROS
In vitro:
Acta Pharmacol Sin. 2004 Apr;25(4):480-4.
Effect of alpha-pinene on nuclear translocation of NF-kappa B in THP-1 cells.[Pubmed: 15066217]

METHODS AND RESULTS:
To study the effects of Alpha-pinene on nuclear translocation of nuclear factor-kappa B (NF-kappa B) and the expression of the inhibitThe majority of FITC-labelled NF-kappa B/p65 was located in the nuclei being stimulated with LPS. Whereas, no such fluorescence was seen in the nuclei of the groups pretreated with Alpha-pinene or control cells. Alpha-pinene pretreatment decreased the NF-kappa B/p65 nuclear translocation in LPS-stimulated THP-1 cells, and this effect was dose-dependent, but there was no reaction in LPS-unstimulated THP-1 cells. Alpha-pinene pretreatment increased I kappa B alpha protein level in cytoplasm, compared with that in LPS-stimulated THP-1 cells.
CONCLUSIONS:
In a dose-related fashion, Alpha-pinene inhibits the nuclear translocation of NF-kappa B induced by LPS in THP-1 cells, and this effect is partly due to the upregulation of I kappa B alpha expression.or of NF-kappa B (I kappa B alpha) in human monocyte THP-1 cell line.
Alpha-pinene Description
Source: The heartwoods of Pinus armandii Franch.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
3''-O-Galloylmyricitrin

Catalog No: CFN95057
CAS No: 143202-36-2
Price: $333/5mg
Oxytroflavoside F

Catalog No: CFN95489
CAS No: 1391144-85-6
Price: $318/5mg
3',5-Dihydroxy-4',6,7-trimethoxyfl...

Catalog No: CFN95316
CAS No: 90850-99-0
Price: $318/5mg
(+)-Lariciresinol 4'-O-beta-D-Gluc...

Catalog No: CFN95283
CAS No: 639857-95-7
Price: $463/5mg
Secotubeimoside I

Catalog No: CFN95347
CAS No: 106235-32-9
Price: $318/10mg
Quasipanaxatriol

Catalog No: CFN95248
CAS No: 171903-78-9
Price: $413/5mg
(Z)-Aldosecologanin (Centauroside)

Catalog No: CFN95079
CAS No: 82474-97-3
Price: $388/5mg
Cassiaside C

Catalog No: CFN95120
CAS No: 119170-52-4
Price: $318/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 7.3421 mL 36.7107 mL 73.4214 mL 146.8429 mL 183.5536 mL
5 mM 1.4684 mL 7.3421 mL 14.6843 mL 29.3686 mL 36.7107 mL
10 mM 0.7342 mL 3.6711 mL 7.3421 mL 14.6843 mL 18.3554 mL
50 mM 0.1468 mL 0.7342 mL 1.4684 mL 2.9369 mL 3.6711 mL
100 mM 0.0734 mL 0.3671 mL 0.7342 mL 1.4684 mL 1.8355 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Ann Bot. 2006 Dec;98(6):1261-9.
alpha-Pinene inhibits growth and induces oxidative stress in roots.[Pubmed: 17028297 ]
Determining the mode of action of allelochemicals is one of the challenging aspects in allelopathic studies. Recently, allelochemicals have been proposed to cause oxidative stress in target tissue and induce an antioxidant mechanism. Alpha-pinene, one of the common monoterpenoids emitted from several aromatic plants including forest trees, is known for its growth-inhibitory activity. However, its mechanism of action remains unexplored.
METHODS AND RESULTS:
The aim of the present study was to determine the inhibitory effect of Alpha-pinene on root growth and generation of reactive oxygen species, as indicators of oxidative stress and changes in activities of antioxidant enzymes.Alpha-pinene inhibited the radicle growth of all the test species. Exposure of C. occidentalis roots to Alpha-pinene enhanced solute leakage, and increased levels of malondialdehyde, proline and hydrogen peroxide, indicating lipid peroxidation and induction of oxidative stress. Activities of the antioxidant enzymes SOD, CAT, GPX, APX and GR were significantly elevated, thereby indicating the enhanced generation of reactive oxygen species (ROS) upon Alpha-pinene exposure. Increased levels of scavenging enzymes indicates their induction as a secondary defence mechanism in response to Alpha-pinene.
CONCLUSIONS:
It is concluded that Alpha-pinene inhibits early root growth and causes oxidative damage in root tissue through enhanced generation of ROS, as indicated by increased lipid peroxidation, disruption of membrane integrity and elevated antioxidant enzyme levels.
Ganoderol B

Catalog No: CFN99064
CAS No: 104700-96-1
Price: $318/5mg
Gancaonin N

Catalog No: CFN95066
CAS No: 129145-52-4
Price: $463/5mg
11-Hydroxy-sugiol

Catalog No: CFN90366
CAS No: 88664-08-8
Price: $490/5mg
8-Prenylkaempferol

Catalog No: CFN92346
CAS No: 28610-31-3
Price: $ / mg
Cimifugin

Catalog No: CFN98612
CAS No: 37921-38-3
Price: $60/20mg
Alloisoimperatorin

Catalog No: CFN95012
CAS No: 35214-83-6
Price: $338/5mg
Jujuboside A

Catalog No: CFN98101
CAS No: 55466-04-1
Price: $70/20mg
Isosinensetin

Catalog No: CFN90806
CAS No: 17290-70-9
Price: $218/20mg
Mulberroside A

Catalog No: CFN99586
CAS No: 102841-42-9
Price: $60/20mg
Geniposidic acid

Catalog No: CFN98337
CAS No: 27741-01-1
Price: $30/20mg
Tags: buy Alpha-pinene | Alpha-pinene supplier | purchase Alpha-pinene | Alpha-pinene cost | Alpha-pinene manufacturer | order Alpha-pinene | Alpha-pinene distributor