Science | Nature | Cell | View More
Natural Products
Ascorbic acid
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Ascorbic acid
Price: $30 / 20mg
CAS No.: 50-81-7
Catalog No.: CFN90048
Molecular Formula: C6H8O8
Molecular Weight: 176.12 g/mol
Purity: >=98%
Type of Compound: Miscellaneous
Physical Desc.: Powder
Source: The fruits of Ziziphus jujuba Mill.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $7.0 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Uniwersytet Gdański (Poland)
  • University of Medicine and Phar... (Romania)
  • University of Malaya (Malaysia)
  • University of Canterbury (New Zealand)
  • Universidad de Ciencias y Artes... (Mexico)
  • Kamphaengphet Rajabhat University (Thailand)
  • Aarhus University (Denmark)
  • Donald Danforth Plant Science C... (USA)
  • Sapienza University of Rome (Italy)
  • Johannes Gutenberg University M... (Germany)
  • Uniwersytet Jagielloński w Kra... (Poland)
  • More...
Package
Featured Products
Kaempferol 3,7-di-O-glucoside

Catalog No: CFN91159
CAS No: 25615-14-9
Price: $288/5mg
2'-Hydroxydaidzein

Catalog No: CFN97687
CAS No: 7678-85-5
Price: $ /
Luteolin-4'-O-glucoside

Catalog No: CFN93776
CAS No: 6920-38-3
Price: $ / mg
Ginsenoside Rb2

Catalog No: CFN99965
CAS No: 11021-13-9
Price: $100/20mg
3',4',5'-Trimethoxyflavone

Catalog No: CFN70439
CAS No: 67858-30-4
Price: $118/10mg
Succinic acid

Catalog No: CFN99100
CAS No: 110-15-6
Price: $30/20mg
Ginsenoside F2

Catalog No: CFN99755
CAS No: 62025-49-4
Price: $40/20mg
Ginsenoside Rg3

Catalog No: CFN99969
CAS No: 14197-60-5
Price: $40/20mg
Trigonelline

Catalog No: CFN90225
CAS No: 535-83-1
Price: $40/20mg
Fisetin

Catalog No: CFN98176
CAS No: 528-48-3
Price: $30/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Ascorbic acid (Vitamin C) is a water-soluble vitamin indicated for the prevention and treatment of scurvy, it has a protective effect on alloxan-induced damage by maintaining the activity of cellular antioxidants, it also protects sperm from endogenous oxidative DNA damage that could affect sperm quality and increases risk of genetic defects, particularly in populations with low ascorbic acid such as smokers.Ascorbic acid can reverse endothelial vasomotor dysfunction in the brachial circulation of patients with coronary artery disease.
Targets: p53 | DNA/RNA Synthesis | Mdm2
In vitro:
Sci Rep . 2018 Jul 27;8(1):11372
Hormetic dose response to L-ascorbic acid as an anti-cancer drug in colorectal cancer cell lines according to SVCT-2 expression[Pubmed: 30054560]
Abstract L-Ascorbic acid (vitamin C, AA) exhibits anti-cancer effects with high-dose treatment through the generation of reactive oxygen species (ROS) and selective damage to cancer cells. The anti-cancer effects of L-Ascorbic acid are determined by sodium-dependent vitamin C transporter 2 (SVCT-2), a transporter of L-Ascorbic acid. In this study, we demonstrate that L-Ascorbic acid treatment showed efficient anti-cancer activity in cell lines with high expression levels of SVCT-2 for a gradient concentration of L-Ascorbic acid from 10 μM -2 mM. However, in low SVCT-2 expressing cell lines, high-dose L-Ascorbic acid (>1 mM) showed anti-cancer effects but low-dose (<10 μM) treatment induced cell proliferation. Such conflicting results that depend on the concentration are called a hormetic dose response. A hormetic dose response to low-dose L-Ascorbic acid was also observed in high SVCT-2 expressing cell lines in the presence of a SVCT family inhibitor. Insufficient uptake of L-Ascorbic acid in low SVCT-2 expressing cancer cell lines cannot generate sufficient ROS to kill cancer cells, resulting in the hormetic response. Molecular analysis confirmed the increased expression of cancer proliferation markers in the hormetic dose response. These results suggest that L-ascorbic exhibits a biphasic effect in cancer cells depending on SVCT-2 expression.
In vivo:
Nutr Res. 2013 Oct;33(10):868-75.
α-Tocopherol, ascorbic acid, and β-carotene protect against oxidative stress but reveal no direct influence on p53 expression in rats subjected to stress.[Pubmed: 24074745]
We hypothesized that α-tocopherol, Ascorbic acid, and β-carotene, either applied individually or in combination, would modulate redox homeostasis and affect the regulation of genes involved in DNA repair under stress conditions.
METHODS AND RESULTS:
To test this hypothesis, we analyzed the influence of these vitamins, either supplied individually or in combination, on the plasma lipid peroxide level and the hepatic level of 8-hydroxy-2'-deoxyguanosine in rats. We also evaluated the expression of p53 and Mdm2 protein in the intestinal epithelium, as these proteins are involved in the cellular regulation of DNA damage repair. Male Wistar rats (n = 112) were supplemented with α-tocopherol (2 mg), Ascorbic acid (12 mg), and β-carotene (1 mg), both individually and in combination, for 14 days; 32 control rats were treated with placebo. Half of the animals in each group (n = 8) were subjected to 15-minute treadmill running at 20 m/min to cause exercise-induced oxidative stress. A statistically significant reduction in lipid peroxide levels was observed in the plasma of rats subjected to exercise and given 2 or 3 of the antioxidants (P < .0001). Exercise, as well as coadministration of the antioxidants, had no significant effect on the amount of DNA damage. Downward trends in the level of p53 protein expression were observed both in exercised and nonexercised animals, especially when the studied vitamins were administered in combination.
METHODS AND RESULTS:
Our findings suggest that α-tocopherol, Ascorbic acid, and β-carotene, when given concurrently, have primarily antioxidant effects on lipids under stress but do not significantly affect the regulation of p53 gene expression.
Am J Kidney Dis. 2006 Apr;47(4):644-54.
Effect of intravenous ascorbic acid in hemodialysis patients with EPO-hyporesponsive anemia and hyperferritinemia.[Pubmed: 16564942 ]
Although erythropoietin (EPO)-hyporesponsive anemia in hemodialysis patients most commonly results from iron deficiency, the contributory role of chronic inflammation and oxidative stress in its pathogenesis is poorly understood. We conducted an open-label prospective study to assess the effect of vitamin C(Ascorbic acid), an antioxidant, on EPO-hyporesponsive anemia in hemodialysis patients with unexplained hyperferritinemia.
METHODS AND RESULTS:
Forty-six of 262 patients in an inner-city hemodialysis center met the inclusion criteria (administration of intravenous iron and EPO for > or = 6 months at a dose > or = 450 U/kg/wk, average 3-month hemoglobin [Hb] level < or = 11.0 g/dL [< or = 110 g/L], ferritin level > or = 500 ng/mL (microg/L), and transferrin saturation [TSAT] < or = 50%). Patients were excluded if they had a clear explanation for the EPO hyporesponsiveness. Four patients refused to participate. The remaining patients were randomly assigned; 20 patients to receive standard care and 300 mg of intravenous vitamin C with each dialysis session (group 1) and 22 patients to receive standard care only (group 2). Study duration was 6 months. During the study, 1 patient from group 1 was removed (upper gastrointestinal bleeding) from final analysis. Monthly assessment included Hb level, mean corpuscular volume, iron level, iron-binding capacity, ferritin level, TSAT, and Hb content in reticulocytes. In addition, biointact parathyroid hormone, aluminum, C-reactive protein (CRP), and liver enzymes were measured every 3 months. Age, sex, race, and time on dialysis therapy were similar in both groups. At 6 months, Hb levels significantly increased from 9.3 to 10.5 g/dL (93.0 to 105.0 g/L) in group 1, but not group 2 (9.3 to 9.6 g/dL [93.0 to 96.0 g/L]; P = 0.0001). Similarly, TSAT increased from 28.9% to 37.3% in group 1, but not group 2 (28.7% to 29.3%; P = 0.0001). EPO dose (477 to 429 versus 474 to 447 U/kg/wk), iron-binding capacity (216 to 194 versus 218 to 257 microg/dL [38.7 to 34.7 versus 39 to 46 micromol/L]), and CRP level (2.8 to 0.9 versus 2.8 to 2.2 mg/dL) decreased significantly in group 1, but not in controls. Changes in Hb content in reticulocytes and ferritin level also were statistically significant in group 1. There was no change in biointact parathyroid hormone levels. Although serum iron levels and intravenous iron doses changed within each group, changes were equal between the 2 groups.
CONCLUSIONS:
In hemodialysis patients with refractory anemia and hyperferritinemia, vitamin C improved responsiveness to EPO, either by augmenting iron mobilization from its tissue stores or through antioxidant effects.
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1999 Nov;124(3):233-7.
Enhanced testicular antioxidant system by ascorbic acid in alloxan diabetic rats.[Pubmed: 10661714]
The diabetic subject is at significantly increased risk of developing testicular changes. Its etiology may involve oxidative damage by free radicals and protection against such damage can be offered by antioxidant supplementation.
METHODS AND RESULTS:
Alloxan elicited significant inhibition of antioxidants including superoxide dismutase, catalase and glutathione reductase activities and decreased glutathione content in testis. These effects were accompanied by significant elevation of testicular lipid peroxidation, decreased plasma testosterone level and a drop in copper and zinc concentrations in testis. The administration of Ascorbic acid after alloxan treatment interfered and prevented alloxan action. Ascorbic acid blunted the increased testicular lipid peroxidation and the decreased plasma testosterone level probably by protecting antioxidants and the loss of copper and zinc from testes.
CONCLUSIONS:
The data suggested that Ascorbic acid has a protective effect on alloxan-induced damage by maintaining the activity of cellular antioxidants.
Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11003-6.
Ascorbic acid protects against endogenous oxidative DNA damage in human sperm.[Pubmed: 1763015]
Damage to the DNA of germ cells can lead to mutation, which may result in birth defects, genetic diseases, and cancer. The very high endogenous rate of oxidative DNA damage and the importance of dietary Ascorbic acid (AA) in preventing this damage has prompted an examination of these factors in human sperm DNA.
METHODS AND RESULTS:
The oxidized nucleoside 8-hydroxy-2'-deoxyguanosine (8-oxo-7,8-dihydro-2'-deoxyguanosine; oxo8dG), 1 of approximately 20 major products of oxidative damage to DNA, was measured in DNA isolated from human sperm provided by healthy subjects and compared to the seminal fluid AA levels. This relationship was studied in two groups. In a group of 24 free-living individuals 20-50 years old high levels of oxo8dG were correlated with low seminal plasma AA. The endogenous level of oxo8dG in this group was 13 fmol per microgram of DNA or approximately 25,000 adducts per sperm cell. The second group of individuals was maintained on a controlled diet that varied only in AA content. When dietary AA was decreased from 250 to 5 mg/day, the seminal fluid AA decreased by half and the level of oxo8dG in sperm DNA increased 91%. Repletion of dietary AA for 28 days (from 5 mg/day to 250 or 60 mg/day) caused a doubling in seminal fluid AA and reduced oxo8dG by 36%.
CONCLUSIONS:
These results indicate that dietary AA protects human sperm from endogenous oxidative DNA damage that could affect sperm quality and increase risk of genetic defects, particularly in populations with low AA such as smokers.
Circulation. 1996 Mar 15;93(6):1107-13.
Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease.[Pubmed: 8653830]
In the setting of atherosclerosis, endothelial vasomotor function is abnormal. Increased oxidative stress has been implicated as one potential mechanism for this observation. We therefore hypothesized that an antioxidant, Ascorbic acid, would improve endothelium-dependent arterial dilation in patients with coronary artery disease.
METHODS AND RESULTS:
Brachial artery endothelium-dependent dilation in response to hyperemia was assessed by high-resolution vascular ultrasound before and 2 hours after oral administration of either 2 g Ascorbic acid or placebo in a total of 46 patients with documented coronary artery disease. Plasma Ascorbic acid concentration increased 2.5-fold 2 hours after treatment (46+/-8 to 114+/-11 micromol/L, P=.001). In the prospectively defined group of patients with an abnormal baseline response (<5% dilation), Ascorbic acid produced marked improvement in dilation (2.0+/-0.6% to 9.7+/-2.0%), whereas placebo had no effect (1.1+/-1.5% to 1.7+/-1.5%, P=.003 for Ascorbic acid versus placebo). Ascorbic acid had no effect on hyperemic flow or arterial dilation to sublingual nitroglycerin.
CONCLUSIONS:
Ascorbic acid reverses endothelial vasomotor dysfunction in the brachial circulation of patients with coronary artery disease. These findings suggest that increased oxidative stress contributes to endothelial dysfunction in patients with atherosclerosis and that endothelial dysfunction may respond to antioxidant therapy.
Ascorbic acid Description
Source: The fruits of Ziziphus jujuba Mill.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Phloretin 3',5'-Di-C-glucoside

Catalog No: CFN95306
CAS No: 357401-40-2
Price: $318/10mg
Quercetin 3-Caffeylrobinobioside

Catalog No: CFN95151
CAS No: 957110-26-8
Price: $413/5mg
Erythro-Guaiacylglycerol-beta-coni...

Catalog No: CFN95416
CAS No: 74474-55-8
Price: $318/5mg
Isosaponarin 2''-O-glucoside (Isov...

Catalog No: CFN95296
CAS No: 63316-27-8
Price: $318/10mg
Isoformononetin

Catalog No: CFN95024
CAS No: 486-63-5
Price: $288/5mg
1,2-Epoxy-10(14)-furanogermacren-6...

Catalog No: CFN95214
CAS No: 383368-24-9
Price: $318/10mg
Isosecotanapartholide

Catalog No: CFN95471
CAS No: 102926-01-2
Price: $318/10mg
Aegineoside

Catalog No: CFN95270
CAS No: 752209-48-6
Price: $413/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.6779 mL 28.3897 mL 56.7795 mL 113.5589 mL 141.9487 mL
5 mM 1.1356 mL 5.6779 mL 11.3559 mL 22.7118 mL 28.3897 mL
10 mM 0.5678 mL 2.839 mL 5.6779 mL 11.3559 mL 14.1949 mL
50 mM 0.1136 mL 0.5678 mL 1.1356 mL 2.2712 mL 2.839 mL
100 mM 0.0568 mL 0.2839 mL 0.5678 mL 1.1356 mL 1.4195 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Animal Research:
Aquaculture, 1998, 161(1–4):453-61.
Dietary ascorbic acid needs of common carp (Cyprinus carpio) larvae.[Reference: WebLink]
As some controversy seem to exist regarding the dietary essentiality of Ascorbic acid (AA) for larval cyprinids, a study was conducted to determine the dietary AA requirements with first-feeding larvae of common carp.
METHODS AND RESULTS:
Six semi-purified diets were formulated to contain graded levels (0, 10, 30, 90, 270, 810 mg kg−1) of AA supplied as ascorbyl polyphosphate. Triplicate groups of 250 larvae each were fed one of the experimental diets using automatic feed dispensers over the light hours of the day (temperature: 24±1°C; photoperiod 16L:8D). A duplicate group was kept unfed. Survival, body length and weight increments were recorded. At the end of the 21 day trial, samples were withdrawn for analyses of whole body vitamin C content.
CONCLUSIONS:
The results indicate that common carp larvae have a dietary requirement for Ascorbic acid. The required level for maximum tissue storage is higher than that needed for survival and maximum growth. Based on growth performance, a dietary requirement of about 45 mg AA equivalent kg−1 was established. Maximal body vitamin C concentration (104–115 μg g−1 wet weight) was observed in larvae fed 270 mg AA equivalent kg−1 or more.
Kaempferol 3,7-di-O-glucoside

Catalog No: CFN91159
CAS No: 25615-14-9
Price: $288/5mg
2'-Hydroxydaidzein

Catalog No: CFN97687
CAS No: 7678-85-5
Price: $ /
Luteolin-4'-O-glucoside

Catalog No: CFN93776
CAS No: 6920-38-3
Price: $ / mg
Ginsenoside Rb2

Catalog No: CFN99965
CAS No: 11021-13-9
Price: $100/20mg
3',4',5'-Trimethoxyflavone

Catalog No: CFN70439
CAS No: 67858-30-4
Price: $118/10mg
Succinic acid

Catalog No: CFN99100
CAS No: 110-15-6
Price: $30/20mg
Ginsenoside F2

Catalog No: CFN99755
CAS No: 62025-49-4
Price: $40/20mg
Ginsenoside Rg3

Catalog No: CFN99969
CAS No: 14197-60-5
Price: $40/20mg
Trigonelline

Catalog No: CFN90225
CAS No: 535-83-1
Price: $40/20mg
Fisetin

Catalog No: CFN98176
CAS No: 528-48-3
Price: $30/20mg
Tags: buy Ascorbic acid | Ascorbic acid supplier | purchase Ascorbic acid | Ascorbic acid cost | Ascorbic acid manufacturer | order Ascorbic acid | Ascorbic acid distributor