Bilobetin | CAS:521-32-4 | Manufacturer ChemFaces

Bilobetin

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Description:

Bilobetin treatment ameliorates hyperlipidaemia, lipotoxicity and insulin resistance in rats by stimulating PPARα-mediated lipid catabolism.

Targets:

PPAR | cAMP

In vivo:

Br J Pharmacol. 2012 Apr;165(8):2692-706.

Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.[Pubmed: 22091731]

The amelioration of insulin resistance by Bilobetin is closely related to its hypolipidaemic effect. The aim of the present study was to determine the insulin-sensitizing mechanism of Bilobetin by elucidating its effect on lipid metabolism.
METHODS AND RESULTS:
Rats fed a high-fat diet were treated with Bilobetin for either 4 or 14 days before applying a hyperinsulinaemic-euglycaemic clamp. Triglyceride and fatty acids labelled with radioactive isotopes were used to track the transportation and the fate of lipids in tissues. The activity of lipid metabolism-related enzymes and β-oxidation rate were measured. Western blot was used to investigate the phosphorylation, translocation and expression of PPARα in several tissues and cultured cells. The location of amino acid residues subjected to phosphorylation in PPARα was also studied. Bilobetin ameliorated insulin resistance, increased the hepatic uptake and oxidation of lipids, reduced very-low-density lipoprotein triglyceride secretion and blood triglyceride levels, enhanced the expression and activity of enzymes involved in β-oxidation and attenuated the accumulation of triglycerides and their metabolites in tissues. Bilobetin also increased the phosphorylation, nuclear translocation and activity of PPARα accompanied by elevated cAMP level and PKA activity. Threonine-129-alanine and/or serine-163-alanine mutations on the PPARα genes and PKA inhibitors prevented the effects of Bilobetin on PPARα. However, cells overexpressing PKA appeared to stimulate the phosphorylation, nuclear translocation and activity of PPARα.
CONCLUSIONS:
Bilobetin treatment ameliorates hyperlipidaemia, lipotoxicity and insulin resistance in rats by stimulating PPARα-mediated lipid catabolism. PKA activation is crucial for this process.

Bilobetin Description

Source:	The leaves of Ginkgo biloba L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Bilobetin
Price:	$238 / 20mg
CAS No.:	521-32-4
Catalog No.:	CFN98846
Molecular Formula:	C₃₁H₂₀O₁₀
Molecular Weight:	552.5 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Yellow powder
Source:	The leaves of Ginkgo biloba L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Anti-hyperlipidemic Compound Library Immunomodulators Compound Library Anti-insulin resistance Compound Library Flavonoids Compound Library PPAR Inhibitor Library cAMP Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.81 mL	9.0498 mL	18.0995 mL	36.1991 mL	45.2489 mL
5 mM	0.362 mL	1.81 mL	3.6199 mL	7.2398 mL	9.0498 mL
10 mM	0.181 mL	0.905 mL	1.81 mL	3.6199 mL	4.5249 mL
50 mM	0.0362 mL	0.181 mL	0.362 mL	0.724 mL	0.905 mL
100 mM	0.0181 mL	0.0905 mL	0.181 mL	0.362 mL	0.4525 mL

CFN70356	Cupressuflavone	3952-18-9	538.5	C₃₀H₁₈O₁₀
CFN97224	4',4'''-Di-O-methylcupressuflavone	74336-91-7	566.5	C₃₂H₂₂O₁₀
CFN95007	8,8''-Bibaicalein	135309-02-3	538.5	C₃₀H₁₈O₁₀
CFN96555	Acuminatanol	948884-38-6	638.49	C₃₀H₂₂O₁₆
CFN96163	2,3-Dihydroamentoflavone 7,4'-dimethyl ether	873999-88-3	568.5	C₃₂H₂₄O₁₀
CFN96119	2,3-Dihydroheveaflavone	110382-42-8	582.6	C₃₃H₂₆O₁₀
CFN96134	2,3-dihydrosciadopitysin	34421-19-7	582.6	C₃₃H₂₆O₁₀
CFN96378	2,3-Dihydropodocarpusflavone A	852875-96-8	554.5	C₃₁H₂₂O₁₀
CFN98755	Tetrahydroamentoflavone	48236-96-0	542.5	C₃₀H₂₂O₁₀
CFN95558	3',3'''-Binaringenin	145399-99-1	542.5	C₃₀H₂₂O₁₀