Science | Nature | Cell | View More
Natural Products
Cyclo(Pro-Ala)
Cyclo(Pro-Ala)
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Cyclo(Pro-Ala)
Price: $218 / 10mg
CAS No.: 65556-33-4
Catalog No.: CFN90282
Molecular Formula: C8H12N2O2
Molecular Weight: 168.20 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The roots of Rubia schumanniana Pritzel
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $77.9 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Imperial College London (United Kingdom)
  • Universitas Airlangga (Indonesia)
  • Mahatma Gandhi University (India)
  • FORTH-IMBB (Greece)
  • Lodz University of Technology (Poland)
  • Melbourne University (Australia)
  • VIB Department of Plant Systems... (Belgium)
  • Universiti Malaysia Pahang (Malaysia)
  • Chinese University of Hong Kong (China)
  • Charles Sturt University (Denmark)
  • University of Canterbury (New Zealand)
  • More...
Package
Featured Products
Phyllanthin

Catalog No: CFN99050
CAS No: 10351-88-9
Price: $288/10mg
Isoliquiritin

Catalog No: CFN99155
CAS No: 5041-81-6
Price: $100/20mg
Kojic acid

Catalog No: CFN94478
CAS No: 501-30-4
Price: $40/20mg
Militarine

Catalog No: CFN90409
CAS No: 58139-23-4
Price: $118/20mg
Gastrodin

Catalog No: CFN99549
CAS No: 62499-27-8
Price: $30/20mg
Myricetin 3-O-beta-D-glucopyranoside

Catalog No: CFN80163
CAS No: 19833-12-6
Price: $413/5mg
Martynoside

Catalog No: CFN97159
CAS No: 67884-12-2
Price: $338/5mg
Parkeol

Catalog No: CFN92825
CAS No: 514-45-4
Price: $ / mg
Petunidin chloride

Catalog No: CFN92036
CAS No: 1429-30-7
Price: $488/5mg
Hederagenin

Catalog No: CFN98695
CAS No: 465-99-6
Price: $30/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Cyclo(Pro-Ala) is a new cell cycle inhibitor.
In vitro:
Journal of Shenyang Pharmaceutical University, 2015(2):107 -10.
Cyclic dipeptides as new cell cycle inhibitors produced by Streptomyces flavoretus [Reference: WebLink]
To find the cell cycle inhibitors from the metabolites of Streptomyces flavoretus 18522.
METHODS AND RESULTS:
Activity-guided isolation was performed on the chloroform extract of the fermentation broth and mycelia of Streptomyces flavoretus 18522 by using ts FT210 cells.Compounds were isolated through various chromatoghraphic methods and elucidated by spectroscopic means.The flow cytometry was used to evaluate the cell cycle inhibiting activity of the fractions and compounds. Six cyclic dipeptides were obtained and identified as cyclo(Ala-Leu)(1),cyclo(Ala-Ile)(2),cyclo(Ala-Val)(3),cyclo(Phe-Leu)(4),Cyclo(Pro-Ala)(5) and cyclo(Phe-Val)(6).
CONCLUSIONS:
Compounds 1-6 are reported as new cell cycle inhibitors for the first time.
Cyclo(Pro-Ala) Description
Source: The roots of Rubia schumanniana Pritzel
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Gambogic acid A

Catalog No: CFN95458
CAS No: 1592842-93-7
Price: $318/5mg
6-O-(E)-Caffeoylglucopyranose

Catalog No: CFN95105
CAS No: 209797-79-5
Price: $298/5mg
Aromadendrene

Catalog No: CFN95074
CAS No: 489-39-4
Price: $40/20mg
Massonianoside D

Catalog No: CFN95500
CAS No: 85115-04-4
Price: $318/10mg
5-O-Coumaroylquinic acid

Catalog No: CFN95507
CAS No: 32451-86-8
Price: $318/5mg
Ganoderic acid L

Catalog No: CFN95022
CAS No: 102607-24-9
Price: $413/5mg
Perlolyrine

Catalog No: CFN95291
CAS No: 29700-20-7
Price: $413/5mg
11beta,13-Dihydrolactucin

Catalog No: CFN95433
CAS No: 83117-63-9
Price: $318/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.9453 mL 29.7265 mL 59.453 mL 118.9061 mL 148.6326 mL
5 mM 1.1891 mL 5.9453 mL 11.8906 mL 23.7812 mL 29.7265 mL
10 mM 0.5945 mL 2.9727 mL 5.9453 mL 11.8906 mL 14.8633 mL
50 mM 0.1189 mL 0.5945 mL 1.1891 mL 2.3781 mL 2.9727 mL
100 mM 0.0595 mL 0.2973 mL 0.5945 mL 1.1891 mL 1.4863 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Int J Pept Protein Res. 1985 Nov;26(5):518-27.
Theoretical pi-pi* absorption and circular dichroic spectra of cyclic dipeptides.[Pubmed: 4086166]

METHODS AND RESULTS:
The dipole interaction model, treated by the partially dispersive normal mode method, is used to calculate circular dichroic spectra of cyclo(Gly-Gly), cyclo (Ala-Gly), cyclo(Ala-Ala), cyclo(Pro-Gly), Cyclo(Pro-Ala), cyclo(Pro-Val), cyclo (Pro-D-Val), and cyclo(Pro-Pro) in the amide pi-pi* absorption band near 190 nm. Assuming a standard backbone geometry, spectra which are in fair to good agreement with experiment are obtained for these molecules. The spectra are predicted to be sensitive to conformations of Pro and Val side chains. The effects of dipeptide ring folding on calculated CD spectra are mostly consistent with those found by other workers, except that it is found that a planar ring conformation of cyclo (Ala-Ala) and cyclo (Ala-Gly) gives predicted spectra comparable to experiment.
CONCLUSIONS:
The same model gives theoretical absorption spectra consistent with available experimental data.
Phyllanthin

Catalog No: CFN99050
CAS No: 10351-88-9
Price: $288/10mg
Isoliquiritin

Catalog No: CFN99155
CAS No: 5041-81-6
Price: $100/20mg
Kojic acid

Catalog No: CFN94478
CAS No: 501-30-4
Price: $40/20mg
Militarine

Catalog No: CFN90409
CAS No: 58139-23-4
Price: $118/20mg
Gastrodin

Catalog No: CFN99549
CAS No: 62499-27-8
Price: $30/20mg
Myricetin 3-O-beta-D-glucopyranoside

Catalog No: CFN80163
CAS No: 19833-12-6
Price: $413/5mg
Martynoside

Catalog No: CFN97159
CAS No: 67884-12-2
Price: $338/5mg
Parkeol

Catalog No: CFN92825
CAS No: 514-45-4
Price: $ / mg
Petunidin chloride

Catalog No: CFN92036
CAS No: 1429-30-7
Price: $488/5mg
Hederagenin

Catalog No: CFN98695
CAS No: 465-99-6
Price: $30/20mg
Tags: buy Cyclo(Pro-Ala) | Cyclo(Pro-Ala) supplier | purchase Cyclo(Pro-Ala) | Cyclo(Pro-Ala) cost | Cyclo(Pro-Ala) manufacturer | order Cyclo(Pro-Ala) | Cyclo(Pro-Ala) distributor