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Demethyl tetrandrine
Demethyl tetrandrine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Demethyl tetrandrine
Price: $30 / 20mg
CAS No.: 33889-68-8
Catalog No.: CFN90482
Molecular Formula: C37H40N2O6
Molecular Weight: 608.72 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The roots of Stephania tetrandra S.Moore.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / $15.4 / In-stock
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Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Demethyl tetrandrine and tetrandrine show inhibition on DNA synthesis, the 50% inhibition doses ( ID50 ) are in L7712 and Sl80 cells are 27.5, 24.5 mg/L and 2.6, 3 .5mg/ L , respectively.
Targets: DNA/RNA Synthesis
In vitro:
《Chinese Pharmacological Bulletin》 1990-01
INHIBITION OF TETRANDRINE AND DEMETHYL TETRANDRINE ON DNA, RNA AND PROTEIN SYNTHESES OF LEUKEMIA 7712 AND SARCOMA 180 CELLS[Reference: WebLink]

METHODS AND RESULTS:
The 50% inhibition doses ( ID50 ) of tetrandrine and Demethyl tetrandrine on DNA synthesis in L7712 and Sl80 cells are 2.6, 3 .5mg/ L and 27.5, 24.5mg/L respectively. The DNA synthesis inhibition is likely due to DNA template damage caused by both natural products. The inhibition of DNA, RNA and protein syntheses by tetrandrine or Demethyl tetrandrine increased with incubating time. The inhibiting activities of two natural products on DNA and RNA synthesis are s-tronger than on protein.
CONCLUSIONS:
There are no differences either in inhibiting activity or in inhibiting mechanism between two natural products.
Demethyl tetrandrine Description
Source: The roots of Stephania tetrandra S.Moore.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.6428 mL 8.214 mL 16.4279 mL 32.8558 mL 41.0698 mL
5 mM 0.3286 mL 1.6428 mL 3.2856 mL 6.5712 mL 8.214 mL
10 mM 0.1643 mL 0.8214 mL 1.6428 mL 3.2856 mL 4.107 mL
50 mM 0.0329 mL 0.1643 mL 0.3286 mL 0.6571 mL 0.8214 mL
100 mM 0.0164 mL 0.0821 mL 0.1643 mL 0.3286 mL 0.4107 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Harpagoside

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CAS No: 19210-12-9
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Diosbulbin B

Catalog No: CFN98014
CAS No: 20086-06-0
Price: $80/20mg
Sophoricoside

Catalog No: CFN90148
CAS No: 152-95-4
Price: $40/20mg
Irisflorentin

Catalog No: CFN99788
CAS No: 41743-73-1
Price: $40/20mg
Schisantherin D

Catalog No: CFN96704
CAS No: 64917-82-4
Price: $ / mg
Beta-Hydroxyisovalerylshikonin

Catalog No: CFN93028
CAS No: 7415-78-3
Price: $ / mg
Cauloside A

Catalog No: CFN96440
CAS No: 17184-21-3
Price: $318/10mg
Isoescin IA

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Caftaric acid

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Malvidin chloride

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Price: $398/10mg
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