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Dimethylcurcumin
Dimethylcurcumin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Dimethylcurcumin
Price: $218 / 20mg
CAS No.: 52328-98-0
Catalog No.: CFN90607
Molecular Formula: C23H24O6
Molecular Weight: 396.43 g/mol
Purity: >=98%
Type of Compound: Phenols
Physical Desc.: Powder
Source: The rhizomes of Curcuma rcenyujin.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $49.6 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
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  • Leibniz-Institut für Pflanzenb... (Germany)
  • University of Leipzig (Germany)
  • Chang Gung University (Taiwan)
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Dimethylcurcumin is an androgen receptor degradation enhancer that effectively suppresses castration resistant prostate cancer cell proliferation and invasion.
Targets: Androgen Receptor
In vitro:
Mol Nutr Food Res. 2008 Sep;52(9):1005-9.
Curcumin in cancer management: recent results of analogue design and clinical studies and desirable future research.[Pubmed: 18186103]

METHODS AND RESULTS:
The ability of the curry constituent curcumin to delay the onset of cancer has been the topic of extensive research for many years. Abundant literature is devoted to mechanisms by which curcumin may mediate this activity. These insights have prompted investigations in which curcumin as lead molecule serves as a scaffold for synthetic chemical attempts to optimize pharmacological potency. Among the published analogues with notable efficacy are Dimethylcurcumin, 1,5-bis(3-pyridyl)-1,4-pentadien-3-one and 3,5-bis-(2-fluorobenzylidene)-piperidinium-4-one acetate. Results of a small number of clinical pilot studies conducted with curcumin at doses of up to 12 g suggest tentatively that it is safe in humans.
CONCLUSIONS:
Prevention of adenoma recurrence constitutes a clinical paradigm worthy of further investigation for curcumin. Future clinical study should include measurement of mechanism-based pharmacodynamic parameters.
Dimethylcurcumin Description
Source: The rhizomes of Curcuma rcenyujin.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.5225 mL 12.6126 mL 25.2251 mL 50.4503 mL 63.0628 mL
5 mM 0.5045 mL 2.5225 mL 5.045 mL 10.0901 mL 12.6126 mL
10 mM 0.2523 mL 1.2613 mL 2.5225 mL 5.045 mL 6.3063 mL
50 mM 0.0505 mL 0.2523 mL 0.5045 mL 1.009 mL 1.2613 mL
100 mM 0.0252 mL 0.1261 mL 0.2523 mL 0.5045 mL 0.6306 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Diosmetin

Catalog No: CFN90210
CAS No: 520-34-3
Price: $30/20mg
Chrysosplenetin

Catalog No: CFN97026
CAS No: 603-56-5
Price: $138/20mg
Gastrodin

Catalog No: CFN99549
CAS No: 62499-27-8
Price: $30/20mg
Scopoletin

Catalog No: CFN97494
CAS No: 92-61-5
Price: $30/20mg
Procyanidin A2

Catalog No: CFN96491
CAS No: 41743-41-3
Price: $238/10mg
Pallidol

Catalog No: CFN92341
CAS No: 105037-88-5
Price: $318/10mg
Albiflorin

Catalog No: CFN99774
CAS No: 39011-90-0
Price: $50/20mg
Luteolin-4'-O-glucoside

Catalog No: CFN93776
CAS No: 6920-38-3
Price: $ / mg
Taraxasterol acetate

Catalog No: CFN97104
CAS No: 6426-43-3
Price: $/mg
Myricetin 3-O-galactoside

Catalog No: CFN97817
CAS No: 15648-86-9
Price: $318/10mg
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