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Epimedin A1
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Epimedin A1
Price: $198 / 20mg
CAS No.: 140147-77-9
Catalog No.: CFN99145
Molecular Formula: C39H50O20
Molecular Weight: 838.8 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: White powder
Source: The herb of Epimedium brevicornum Maxim.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $95.5 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Epimedin A has anti-osteoporosis activity.
In vitro:
Drug Metab Dispos,2015,43:1590–1600.
Intestinal Absorption and Metabolism of Epimedium Flavonoids in osteoporosis rats. [Reference: WebLink]
Herba Epimdii is a traditional Chinese medicine used to treat osteoporosis. Its main pharmacological ingredients are flavonoids. In previous studies conducted in healthy animals, we showed that epimedium flavonoids could be hydrolyzed into secondary glycosides or aglycon by intestinal flora or enzymes, thereby enhancing their absorption and antiosteoporosis activity. To study the medicine in the pathologic state, epimedium flavonoids were incubated with intestinal mucosa and feces in vitro and intestinal perfusion in situ to explore the differences in absorption and metabolism between sham and osteoporosis rats.
METHODS AND RESULTS:
For osteoporosis rats, the hydrolysis rates of icariin, epimedin A(Epimedin A1), epimedin B, and epimedin C incubated with intestinal flora for 1 hour were reduced by 0.19, 0.26, 0.19, and 0.14, respectively, compared with that in sham rats. Hydrolysis rates were reduced by 0.21, 0.24, 0.08, and 0.31 for icariin, epimedin A, epimedin B, and epimedin C incubated with duodenal enzymes for 1 hour and by 0.13, 0.09, 0.07, and 0.47 for icariin, epimedin A, epimedin B, and epimedin C incubated with jejunum enzymes, respectively, compared with the sham group. In addition, the apparent permeability coefficient and elimination percentage of the four epimedium flavonoids in the duodenum, jejunum, ileum, and colon decreased by 29%–44%, 32%–50%, 40%–56%, and 27%–53% compared with that in sham rats, respectively. The main metabolites of the four epimedium flavonoids were the same for the two groups after intestinal perfusion, or flora and enzyme incubation.
CONCLUSIONS:
In conclusion, the amount and activity of intestinal flora and enzymes changed in ovariectomized rats, which affected the intestinal absorption and hydrolysis of epimedium flavonoids whose structures contain 7-glucose.
Epimedin A1 Description
Source: The herb of Epimedium brevicornum Maxim.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

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ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.1922 mL 5.9609 mL 11.9218 mL 23.8436 mL 29.8045 mL
5 mM 0.2384 mL 1.1922 mL 2.3844 mL 4.7687 mL 5.9609 mL
10 mM 0.1192 mL 0.5961 mL 1.1922 mL 2.3844 mL 2.9804 mL
50 mM 0.0238 mL 0.1192 mL 0.2384 mL 0.4769 mL 0.5961 mL
100 mM 0.0119 mL 0.0596 mL 0.1192 mL 0.2384 mL 0.298 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Spectrochimica Acta Part A Molecular & Biomolecular Spectroscopy, 2016, 171:351-360.
Rapid measurement of epimedin A, epimedin B, epimedin C, icariin, and moisture in Herba Epimedii using near infrared spectroscopy.[Reference: WebLink]

METHODS AND RESULTS:
In this work, near infrared (NIR) spectroscopy was used in combination with chemometrics to determine the epimedin A(Epimedin A1 ), epimedin B, epimedin C, icariin, and moisture contents of Herba Epimedii. The variable selection method genetic algorithm (GA) and regression tool support vector machine (SVM) were used to improve the model performance. Four different calibration models, namely Full-PLS, GA-PLS, Full-SVM, and GA-SVM, were established, and their performances in terms of prediction accuracy and model robustness were systemically studied and compared. In conclusion, the performances of the models based on the efficient variables selected through GA were better than those based on full spectra, and the nonlinear models were superior over the linear models. In addition, the GA-SVM model demonstrated the optimal performance in predicting five quality parameters (viz. epimedin A, epimedin B, epimedin C, icariin, and moisture). For GA-SVM, the determination coefficient (Rp2), root-mean-square error (RMSEP), and residual predictive deviation (RPD) for the prediction set were 0.9015, 0.0268%, and 2.20 for epimedin A; 0.9089, 0.0656%, and 3.08 for epimedin B; 0.9056, 0.1787%, and 3.18 for epimedin C; 0.8192, 0.0657%, and 2.26 for icariin; and 0.9367, 0.2062%, and 4.12 for moisture, correspondingly.
CONCLUSIONS:
Results indicated that NIR spectroscopy coupled with GA-SVM calibration can be used as a reliable alternative strategy to measure the epimedin A, epimedin B, epimedin C, icariin, and moisture contents of Herba Epimedii because this technique is fast, economic, and nondestructive compared with traditional chemical methods.
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