Science | Nature | Cell | View More
Natural Products
(-)-Gallocatechin gallate
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name (-)-Gallocatechin gallate
Price: $60 / 20mg
CAS No.: 4233-96-9
Catalog No.: CFN99571
Molecular Formula: C22H18O11
Molecular Weight: 458.37 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: White powder
Source: The woods of Acacia catechu (L.F.) Willd.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $12.7 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Stanford University (USA)
  • Mendel University in Brno (Czech Republic)
  • Yale University (USA)
  • Macau University of Science and... (China)
  • Massachusetts General Hospital (USA)
  • Johannes Gutenberg University M... (Germany)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • University of Hull (United Kingdom)
  • Utrecht University (Netherlands)
  • Chinese University of Hong Kong (China)
  • Tokyo Woman's Christian University (Japan)
  • More...
Package
Featured Products
Taraxasterol

Catalog No: CFN99074
CAS No: 1059-14-9
Price: $338/20mg
Fangchinoline

Catalog No: CFN99167
CAS No: 436-77-1
Price: $40/20mg
Vitexin

Catalog No: CFN98601
CAS No: 3681-93-4
Price: $60/20mg
Stachydrine hydrochloride

Catalog No: CFN98506
CAS No: 4136-37-2
Price: $30/20mg
Acacetin

Catalog No: CFN98744
CAS No: 480-44-4
Price: $30/20mg
Juglone

Catalog No: CFN90497
CAS No: 481-39-0
Price: $40/20mg
Luteolin-3-O-beta-D-glucuronide

Catalog No: CFN93187
CAS No: 53527-42-7
Price: $238/10mg
Alloimperatorin

Catalog No: CFN93037
CAS No: 642-05-7
Price: $298/10mg
Umckalin

Catalog No: CFN70362
CAS No: 43053-62-9
Price: $ / mg
Cinnamic aldehyde

Catalog No: CFN90321
CAS No: 14371-10-9
Price: $30/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: (-)-Gallocatechin gallate has cancer-preventive activities, it can precipitate cholesterol, decreasee osteoclastogenesis at 20 microM.
Targets: NF-κB | mRNA
In vitro:
J Agric Food Chem. 2009 Aug 26;57(16):7293-7.
Effects of tea catechins, epigallocatechin, gallocatechin, and gallocatechin gallate, on bone metabolism.[Pubmed: 19653629 ]

METHODS AND RESULTS:
In this study, three tea catechins, epigallocatechin (EGC), gallocatechin (GC), and (-)-Gallocatechin gallate (GCG), were investigated for their effects on bone metabolism. The effects of the tea catechins on bone formation were evaluated using cultured rat osteoblast-like osteosarcoma cell line UMR-106. EGC stimulated alkaline phosphatase activity significantly at concentrations of 10 and 20 microM. The amount of mineralization also increased significantly with EGC. On another cell culture platform, EGC significantly inhibited osteoclast formations from RAW 264.7 cells upon receptor activation of nuclear factor-kappaB ligand induction on the fourth day of treatment, at a concentration of 10 microM. EGC also dose-dependently inhibited the mRNA expression of tatrate-resistant acid phosphatase. GC and GCG could decrease osteoclastogenesis at 20 microM.
CONCLUSIONS:
The present study illustrated that the tea catechins, EGC in particular, had positive effects on bone metabolism through a double process of promoting osteoblastic activity and inhibiting osteoclast differentiations.
J Agric Food Chem. 2003 Dec 3;51(25):7303-7.
Heat-epimerized tea catechins rich in gallocatechin gallate and catechin gallate are more effective to inhibit cholesterol absorption than tea catechins rich in epigallocatechin gallate and epicatechin gallate.[Pubmed: 14640575]
It has been known that tea catechins, (-)-epicatechin (1), (-)-epigallocatechin (2), (-)-epicatechin gallate (3), and (-)-epigallocatechin gallate (4) are epimerized to(-)-catechin (5), (-)-gallocatechin (6), (-)-catechin gallate (7), and (-)-Gallocatechin gallate (8), respectively, during retort pasteurization. We previously reported that tea catechins, mainly composed of 3 and 4, effectively inhibit cholesterol absorption in rats.
METHODS AND RESULTS:
In this study, the effect of heat-epimerized catechins on cholesterol absorption was compared with tea catechins. Both tea catechins and heat-epimerized catechins lowered lymphatic recovery of cholesterol in rats cannulated in the thoracic duct and epimerized catechins were more effective than tea catechins. The effect of purified catechins on micellar solubility of cholesterol was examined in an in vitro study. The addition of gallate esters of catechins reduced micellar solubility of cholesterol by precipitating cholesterol from bile salt micelles. Compounds 7 and 8 were more effective to precipitate cholesterol than 3 and 4, respectively.
CONCLUSIONS:
These observations strongly suggest that heat-epimerized catechins may be more hypocholesterolemic than tea catechins.
Food Chem . 2017 Nov 15;235:227-233.
C-geranylated flavanones from YingDe black tea and their antioxidant and α-glucosidase inhibition activities[Pubmed: 28554631]
Abstract YingDe black tea is produced from crude tea prepared from leaves of Camellia sinensis var. assamica. In this work, we isolated and identified five novel flavanones, namely, amelliaone A-E (1-5), along with seven known compounds 6-12 from the ethanol extract of YingDe black tea. The structures of these five novel phenolic compounds were determined using extensive 1D and 2D nuclear magnetic resonance spectroscopy experiments. The compounds were further evaluated for antioxidant, α-glucosidase inhibitory, and cytotoxic activities. Compound 1 exhibited higher α-glucosidase inhibitory activity with a half-maximum inhibitory concentration value (IC50) of 10.2μM compared with acarbose (18.2μM). Keywords: (−)-Epicatechin (PubChem CID: 72276); (−)-Gallocatechin gallate (PubChem CID: 199472); Amentoflavone (PubChem CID: 5281600); Apigenin (PubChem CID: 5280443); Camellia var. assamica; Epigallocatechin gallate (PubChem CID: 65064); Flavanone; Gallic acid (PubChem CID: 370); Quercetin (PubChem CID: 5280343); YingDe black tea; α-Glucosidase inhibitory activity.
(-)-Gallocatechin gallate Description
Source: The woods of Acacia catechu (L.F.) Willd.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
4-Methoxybenzoylacetic acid

Catalog No: CFN95446
CAS No: 13422-77-0
Price: $318/5mg
Moreollic acid

Catalog No: CFN95437
CAS No: 173792-68-2
Price: $318/5mg
Secologanic acid

Catalog No: CFN95028
CAS No: 60077-46-5
Price: $418/20mg
Cannabisin B

Catalog No: CFN95268
CAS No: 144506-17-2
Price: $413/5mg
Bruceantinol B

Catalog No: CFN95216
CAS No: 1822332-33-1
Price: $318/5mg
Sophoraflavone A

Catalog No: CFN95510
CAS No: 105594-08-9
Price: $318/10mg
Yuankanin

Catalog No: CFN95128
CAS No: 77099-20-8
Price: $318/5mg
Epischisandrone

Catalog No: CFN95212
CAS No: 98619-26-2
Price: $413/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1816 mL 10.9082 mL 21.8164 mL 43.6329 mL 54.5411 mL
5 mM 0.4363 mL 2.1816 mL 4.3633 mL 8.7266 mL 10.9082 mL
10 mM 0.2182 mL 1.0908 mL 2.1816 mL 4.3633 mL 5.4541 mL
50 mM 0.0436 mL 0.2182 mL 0.4363 mL 0.8727 mL 1.0908 mL
100 mM 0.0218 mL 0.1091 mL 0.2182 mL 0.4363 mL 0.5454 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Cell Research:
Biochim Biophys Acta. 1999 Oct 18;1472(1-2):42-50.
Epigallocatechin gallate and gallocatechin gallate in green tea catechins inhibit extracellular release of Vero toxin from enterohemorrhagic Escherichia coli O157:H7.[Pubmed: 10572924]
We studied the effects of six catechin derivatives (catechin, epigallocatechin, epicatechin, epicatechin gallate, epigallocatechin gallate (EGCg) and (-)-Gallocatechin gallate(GCg)) in green tea on the production and extracellular release of Vero toxins (VTs) from enterohemorrhagic Escherichia coli (EHEC) cultured at 37 degrees C for 24 h. EGCg and GCg in the culture medium markedly inhibited extracellular VTs release from EHEC cells into the culture supernatant fluid at concentrations of 0.05 mg/ml or higher, as estimated by both the reversed passive latex agglutination assay and cytotoxic assay using Vero cells. Production and extracellular release of maltose binding protein, a periplasmic protein, into the culture supernatant were also inhibited by EGCg and (-)-Gallocatechin gallate, indicating that their inhibitory effect on release from periplasm into the outer milieu is not specific to VTs, but general to the proteins accumulated in EHEC periplasm.
Taraxasterol

Catalog No: CFN99074
CAS No: 1059-14-9
Price: $338/20mg
Fangchinoline

Catalog No: CFN99167
CAS No: 436-77-1
Price: $40/20mg
Vitexin

Catalog No: CFN98601
CAS No: 3681-93-4
Price: $60/20mg
Stachydrine hydrochloride

Catalog No: CFN98506
CAS No: 4136-37-2
Price: $30/20mg
Acacetin

Catalog No: CFN98744
CAS No: 480-44-4
Price: $30/20mg
Juglone

Catalog No: CFN90497
CAS No: 481-39-0
Price: $40/20mg
Luteolin-3-O-beta-D-glucuronide

Catalog No: CFN93187
CAS No: 53527-42-7
Price: $238/10mg
Alloimperatorin

Catalog No: CFN93037
CAS No: 642-05-7
Price: $298/10mg
Umckalin

Catalog No: CFN70362
CAS No: 43053-62-9
Price: $ / mg
Cinnamic aldehyde

Catalog No: CFN90321
CAS No: 14371-10-9
Price: $30/20mg
Tags: buy (-)-Gallocatechin gallate | (-)-Gallocatechin gallate supplier | purchase (-)-Gallocatechin gallate | (-)-Gallocatechin gallate cost | (-)-Gallocatechin gallate manufacturer | order (-)-Gallocatechin gallate | (-)-Gallocatechin gallate distributor