Ganoderic acid C2 | CAS:103773-62-2 | Manufacturer ChemFaces

Ganoderic acid C2

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Product Name	Ganoderic acid C2
Price:	$318 / 20mg
CAS No.:	103773-62-2
Catalog No.:	CFN92054
Molecular Formula:	C₃₀H₄₆O₇
Molecular Weight:	518.7 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The fruit body of Ganoderma lucidum.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $111.4 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Ganoderic acid C2 has anti-inflammatory,and anti-tumor-promoting activities. Ganoderic acid C2 can inhibit histamine release, it also has inhibitory effects on the induction of Epstein-Barr Virus early antigen.

Targets:

Histamine Receptor | Immunology & Inflammation related

In vitro:

J Pharm Biomed Anal. 2013 Mar 5;75:64-73.

Structural characterization of minor metabolites and pharmacokinetics of ganoderic acid C2 in rat plasma by HPLC coupled with electrospray ionization tandem mass spectrometry.[Pubmed: 23312386]

METHODS AND RESULTS:
The metabolites and pharmacokinetics of Ganoderic acid C2 (GAC2), a bioactive triterpenoid in Ganoderma lucidum in rat plasma were investigated by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS). Totally, ten minor phase I metabolites of GAC2 were characterized after oral administration of GAC2, on the basis of their mass fragmentation pathways or direct comparison with authentic compounds by high-performance liquid chromatography coupled with diode array detection and electrospray ion trap tandem mass spectrometry (HPLC-DAD-ESI-MS(n)), and liquid chromatography coupled with electrospray ionization hybrid ion trap and time-of-flight mass spectrometry (LC-ESI-IT-TOF/MS) methods. Moreover, a rapid and specific method for quantification of GAC2 in rat plasma after oral administration was developed by using a liquid-liquid extraction procedure and HPLC-ESI-MS/MS analysis.
CONCLUSIONS:
It is the first time to report the metabolites and pharmacokinetics of GAC2.

Ganoderic acid C2 Description

Source:	The fruit body of Ganoderma lucidum.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Planta Med. 2010 Oct;76(15):1691-3.

Inhibition of aldose reductase in vitro by constituents of Ganoderma lucidum.[Pubmed: 20379959 ]

CHCl(3) extract of the fruiting body of Ganoderma lucidum was found to show inhibitory activity on human aldose reductase in vitro. From the acidic fraction, potent human aldose reductase inhibitors, Ganoderic acid C2 (1) and ganoderenic acid A (2), were isolated together with three related compounds. It was found that the free carboxyl group of Ganoderic acid C2 and ganoderenic acid A is essential in eliciting the inhibitory activity considering the much lower activity of their methyl esters.

Structure Identification:

Bioorg Med Chem Lett. 2011 Dec 15;21(24):7295-7.

Structure-activity relationships of ganoderma acids from Ganoderma lucidum as aldose reductase inhibitors.[Pubmed: 22047696]

A series of lanostane-type triterpenoids, known as ganoderma acids were isolated from the fruiting body of Ganoderma lucidum. Some of these compounds were identified as active inhibitors of the in vitro human recombinant aldose reductase. To clarify the structural requirement for inhibition, some structure-activity relationships were determined.
METHODS AND RESULTS:
Our structure-activity studies of ganoderma acids revealed that the OH substituent at C-11 is an important feature and the carboxylic group in the side chain is essential for the recognition of aldose reductase inhibitory activity. Moreover, double bond moiety at C-20 and C-22 in the side chain contributes to improving aldose reductase inhibitory activity. In the case of Ganoderic acid C2, all of OH substituent at C-3, C-7 and C-15 is important for potent aldose reductase inhibition.
CONCLUSIONS:
These results provide an approach to understanding the structural requirements of ganoderma acids from G. lucidum for aldose reductase inhibitor. This understanding is necessary to design a new-type of aldose reductase inhibitor.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Hepatoprotective Compound Library Toxicity Compound Library Triterpenoids Compound Library Immunology & Inflammation related Inhibitor Library Histamine Receptor Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9279 mL	9.6395 mL	19.279 mL	38.5579 mL	48.1974 mL
5 mM	0.3856 mL	1.9279 mL	3.8558 mL	7.7116 mL	9.6395 mL
10 mM	0.1928 mL	0.9639 mL	1.9279 mL	3.8558 mL	4.8197 mL
50 mM	0.0386 mL	0.1928 mL	0.3856 mL	0.7712 mL	0.9639 mL
100 mM	0.0193 mL	0.0964 mL	0.1928 mL	0.3856 mL	0.482 mL

CFN95551	Methyl ganoderate B	81907-65-5	530.7	C₃₁H₄₆O₇
CFN92991	Ganoderenic acid B	100665-41-6	514.65	C₃₀H₄₂O₇
CFN95534	Methyl ganoderenate B	N/A	528.7	C₃₁H₄₄O₇
CFN91782	(3beta,7beta,12beta,20Z)- 3,7,12- trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid	1961358-02-0	530.66	C₃₀H₄₂O₈
CFN92054	Ganoderic acid C2	103773-62-2	518.7	C₃₀H₄₆O₇
CFN92051	Ganoderic acid A	81907-62-2	516.7	C₃₀H₄₄O₇
CFN95550	Methyl ganoderate A	105742-78-7	530.7	C₃₁H₄₆O₇
CFN95058	Methyl lucidenate G	102607-20-5	490.6	C₂₈H₄₂O₇
CFN92053	Ganoderic acid C1	95311-97-0	514.7	C₃₀H₄₂O₇
CFN90297	Ganoderic acid LM2	508182-41-0	514.66	C₃₀H₄₂O₇