Huperzine B | CAS:103548-82-9 | Manufacturer ChemFaces

Huperzine B

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $40.8 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Huperzine B Description

Source:	The herbs of Lycopodium serratum.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Acta Pharmacol Sin. 2009 Aug;30(8):1195-203.

Novel 16-substituted bifunctional derivatives of huperzine B: multifunctional cholinesterase inhibitors.[Pubmed: 19578388]

To design novel bifunctional derivatives of Huperzine B (HupB) based on the concept of dual binding site of acetylcholinesterase (AChE) and evaluate their pharmacological activities for seeking new drug candidates against Alzheimer's disease (AD).
METHODS AND RESULTS:
Novel 16-substituted bifunctional derivatives of Huperzine B were synthesized through chemical reactions. The inhibitory activities of the derivatives toward AChE and butyrylcholinesterase (BuChE) were determined in vitro by modified Ellman's method. Cell viability was quantified by the reduction of MTT. A new preparative method was developed for the generation of 16-substituted derivatives of Huperzine B, and pharmacological trials indicated that the derivatives were multifunctional cholinesterase inhibitors targeting both AChE and BuChE. Among the derivatives tested, 9c, 9e, 9f, and 9i were 480 to 1360 times more potent as AChE inhibitors and 370 to 1560 times more potent as BuChE inhibitors than the parent Huperzine B. Further preliminary pharmacological trials of derivatives 9c and 9i were performed, including examining the mechanism of AChE inhibition, the substrate kinetics of the enzyme inhibition, and protection against hydrogen peroxide (H2O2)-induced cytotoxicity in PC12 cells.
CONCLUSIONS:
Preliminary pharmacological evaluation indicated that 16-substituted derivatives of Huperzine B, particularly 9c and 9i, would be potentially valuable new drug candidates for AD therapy, and further exploration is needed to evaluate their pharmacological and clinical efficacies.

Structure Identification:

Bioorg Med Chem. 2007 Feb 1;15(3):1394-408.

Study on dual-site inhibitors of acetylcholinesterase: Highly potent derivatives of bis- and bifunctional huperzine B.[Pubmed: 17126020]

Natural (-)-Huperzine B (HupB), isolated from Chinese medicinal herb, displayed moderate inhibitory activity of acetylcholinesterase (AChE).
METHODS AND RESULTS:
Based on the active dual-site of AChE, a series of novel derivatives of bis- and bifunctional HupB were designed and synthesized. The AChE inhibition potency of most derivatives of HupB was enhanced about 2-3 orders of magnitude as compared with the parental HupB. Among bis-HupB derivatives, 12h exhibited the most potent in the AChE inhibition and has been evaluated for its pharmacological actions in vivo on ChE inhibition, cognitive enhancement, and neuroprotection.
CONCLUSIONS:
The docking study on the bis-HupB derivatives 12 series with TcAChE has demonstrated that the ligands bound to the dual-site of the enzyme in different level.

Product Name	Huperzine B
Price:	$288 / 20mg
CAS No.:	103548-82-9
Catalog No.:	CFN99960
Molecular Formula:	C₁₆H₂₀N₂O
Molecular Weight:	256.35 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Lycopodium serratum.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Anti-organophosphate intoxication Compound Library Memory enhancers Compound Library Alkaloids Compound Library AChR Inhibitor Library

Description:	Huperzine B is a efficient inhibitor of human brain AChE, it can enhance ognitive and protect neuro, may be potentially new drug candidates for Alzheimer's disease therapy.
Targets:	AChR

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.9009 mL	19.5046 mL	39.0092 mL	78.0183 mL	97.5229 mL
5 mM	0.7802 mL	3.9009 mL	7.8018 mL	15.6037 mL	19.5046 mL
10 mM	0.3901 mL	1.9505 mL	3.9009 mL	7.8018 mL	9.7523 mL
50 mM	0.078 mL	0.3901 mL	0.7802 mL	1.5604 mL	1.9505 mL
100 mM	0.039 mL	0.195 mL	0.3901 mL	0.7802 mL	0.9752 mL

CFN90345	Huperzine C	163089-71-2	242.32	C₁₅H₁₈N₂O
CFN99959	Huperzine A	120786-18-7	242.32	C₁₅H₁₈N₂O
CFN99960	Huperzine B	103548-82-9	256.35	C₁₆H₂₀N₂O
CFN89068	N-Demethyl-alpha-obscurine	34399-44-5	260.38	C₁₆H₂₄N₂O
CFN96411	Alpha-Obscurine	596-55-4	274.4	C₁₇H₂₆N₂O
CFN89120	Lucidioline	22594-91-8	263.38	C₁₆H₂₅NO₂
CFN89109	6alpha-Hydroxylycopodine	21061-92-7	263.38	C₁₆H₂₅NO₂
CFN99133	Dendrobine	2115-91-5	263.38	C₁₆H₂₅NO₂
CFN96086	3-Chloro-4-hydroxypiperidin-2-one	174204-83-2	149.6	C₅H₈ClNO₂
CFN96112	5,6-Dihydropyridin-2(1H)-one	6052-73-9	97.1	C₅H₇NO