Isochlorogenic acid A | CAS:2450-53-5 | Manufacturer ChemFaces

Isochlorogenic acid A

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Description:

Isochlorogenic acid A has antiviral, antioxidant, hepatoprotective and potent anti-hepatitis B activities.

Targets:

HBV | HO-1

In vitro:

J Ethnopharmacol. 2012 Oct 31;144(1):190-4.

Hepatoprotective and antiviral properties of isochlorogenic acid A from Laggera alata against hepatitis B virus infection.[Pubmed: 22982394]

The aim of this study was to determine the anti-hepatitis B effect of Isochlorogenic acid A isolated from Laggera alata (Asteraceae), a traditional Chinese herbal medicine.
METHODS AND RESULTS:
The anti-hepatitis B activity of Isochlorogenic acid A was evaluated by the D-galactosamine (D-GalN)-induced HL-7702 hepatocyte damage model and the HBV-transfected HepG2.2.15 cells. Isochlorogenic acid A significantly improved HL-7702 hepatocyte viability and markedly inhibited the productions of HBsAg and HBeAg. The inhibitory rates of Isochlorogenic acid A on the HBsAg and HBeAg expressions were 86.9% and 72.9%, respectively. In addition, Isochlorogenic acid A declined markedly the content of hepatitis B virus covalently closed circular DNA (HBV cccDNA) and induced significantly the heme oxygenase-1 (HO-1) expression in HepG2.2.15 cells.
CONCLUSIONS:
Isochlorogenic acid A was verified to possess the potent anti-hepatitis B activity. The anti-HBV target of Isochlorogenic acid A is probably associated with blocking the translation step of the HBV replication. Overexpression of HO-1 may contribute to the anti-HBV activity of Isochlorogenic acid A by reducing the stability of the HBV core protein and thus blocking the refill of nuclear HBV cccDNA. Additionally, the hepatoprotective effect of Isochlorogenic acid A could be achieved by its antioxidative property and induction of HO-1.

Isochlorogenic acid A Description

Source:	The flowerbuds of Lonicera japonica Thunb.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

PLoS One. 2014 Sep 2;9(9):e106254.

The activity-integrated method for quality assessment of reduning injection by on-line DPPH-CE-DAD.[Pubmed: 25181475]

METHODS AND RESULTS:
A sensitive on-line DPPH-CE-DAD method was developed and validated for both screening and determining the concentration of seven antioxidants of Reduning injection. The pH and concentrations of buffer solution, SDS, β-CD and organic modifier were studied for the detection of DPPH and seven antioxidants. By on-line mixing DPPH and sample solution, a DPPH-CE method for testing the antioxidant activity of the complex matrix was successfully established and used to screen the antioxidant components of Reduning injection. Then, antioxidant components including caffeic acid, Isochlorogenic acid A, isochlorogenic acid B, isochlorogenic acid C, chlorogenic acid, neochlorogenic acid and cryptochlorogenic acid were quantified by the newly established CE-DAD method. Finally, the total antioxidant activity and the multiple active components were selected as markers to evaluate the quality of Reduning injection.
CONCLUSIONS:
The results demonstrated that the on-line DPPH-CE-DAD method was reagent-saving, rapid and feasible for on-line simultaneous determination of total pharmacological activity and contents of multi-components samples. It was also a powerful method for evaluating the quality control and mechanism of action of TCM injection.

Product Name	Isochlorogenic acid A
Price:	$50 / 20mg
CAS No.:	2450-53-5
Catalog No.:	CFN99118
Molecular Formula:	C₂₅H₂₄O₁₂
Molecular Weight:	516.45 g/mol
Purity:	>=98%
Type of Compound:	Phenylpropanoids
Physical Desc.:	Powder
Source:	The flowerbuds of Lonicera japonica Thunb.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antioxidants Compound Library Antiviral Compound Library Phenylpropanoids Compound Library HO-1 Inhibitor Library HBV Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9363 mL	9.6815 mL	19.363 mL	38.7259 mL	48.4074 mL
5 mM	0.3873 mL	1.9363 mL	3.8726 mL	7.7452 mL	9.6815 mL
10 mM	0.1936 mL	0.9681 mL	1.9363 mL	3.8726 mL	4.8407 mL
50 mM	0.0387 mL	0.1936 mL	0.3873 mL	0.7745 mL	0.9681 mL
100 mM	0.0194 mL	0.0968 mL	0.1936 mL	0.3873 mL	0.4841 mL

CFN90238	3,4,5-Tricaffeoylquinic acid	86632-03-3	678.59	C₃₄H₃₀O₁₅
CFN00384	Caftaric acid	67879-58-7	312.2	C₁₃H₁₂O₉
CFN99725	Chicoric acid	6537-80-0	474.37	C₂₂H₁₈O₁₂
CFN99122	1,4-Dicaffeoylquinic acid	1182-34-9	516.46	C₂₅H₂₄O₁₂
CFN90937	1,5-Dicaffeoylquinic acid	19870-46-3	516.5	C₂₅H₂₄O₁₂
CFN95430	4-O-Caffeoyl-3-O-syringoylquinic acid	1207645-17-7	534.5	C₂₅H₂₆O₁₃
CFN99119	Isochlorogenic acid B	14534-61-3	516.45	C₂₅H₂₄O₁₂
CFN91970	Ethyl 3,4-dicaffeoylquinate	143051-73-4	544.50	C₂₇H₂₈O₁₂
CFN90856	3,4-Di-O-caffeoylquinic acid methyl ester	114637-83-1	530.5	C₂₆H₂₆O₁₂
CFN99118	Isochlorogenic acid A	2450-53-5	516.45	C₂₅H₂₄O₁₂