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Napellonine
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Product Name Napellonine
Price: $218 / 20mg
CAS No.: 509-24-0
Catalog No.: CFN90393
Molecular Formula: C22H31NO3
Molecular Weight: 357.49 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Cryst.
Source: The roots of Aconitumso ngoricum Popov
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $42.4 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Napellonine shows favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays.
Targets: FGFR4
In vivo:
Sci Rep. 2017 Jun 15;7(1):3569.
A novel cell membrane affinity sample pretreatment technique for recognition and preconcentration of active components from traditional Chinese medicine.[Pubmed: 28620157 ]
We describe a novel biomembrane affinity sample pretreatment technique to quickly screen and preconcentrate active components from traditional Chinese medicine (TCM), which adopts cell membrane coated silica particles (CMCSPs) as affinity ligands which benefit the biomembrane's ability to maximize simulation of drug-receptor interactions in vivo.
METHODS AND RESULTS:
In this study, the prepared CMCSPs formed by irreversible adsorption of fibroblast growth factor receptor 4 (FGFR4) cell membrane on the surface of silica were characterized using different spectroscopic and imaging instruments. Drug binding experiments showed the excellent adsorption rate and adsorption capacity of FGFR4/CMCSPs compared with non-coated silica particles. The FGFR4/CMCSPs were used as solid-phase extraction sorbents to pretreat the TCM Aconitum szechenyianum Gay. The resultant FGFR4/CMCSPs exhibited good performance. In addition, high selectivity and recognition ability of the FGFR4/CMCSPs were determined by selectivity experiments. Four alkaloid were screened and identified, one of these alkaloid, Napellonine, showed favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays.
CONCLUSIONS:
The proposed cell membrane affinity sample pretreatment method is a reliable, effective and time-saving method for fast screening and enriching active compounds and can be extended to pretreat other TCMs as leading compounds resources.
Napellonine Description
Source: The roots of Aconitumso ngoricum Popov
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.7973 mL 13.9864 mL 27.9728 mL 55.9456 mL 69.932 mL
5 mM 0.5595 mL 2.7973 mL 5.5946 mL 11.1891 mL 13.9864 mL
10 mM 0.2797 mL 1.3986 mL 2.7973 mL 5.5946 mL 6.9932 mL
50 mM 0.0559 mL 0.2797 mL 0.5595 mL 1.1189 mL 1.3986 mL
100 mM 0.028 mL 0.1399 mL 0.2797 mL 0.5595 mL 0.6993 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Muscone

Catalog No: CFN99518
CAS No: 541-91-3
Price: $30/20mg
Astragaloside I

Catalog No: CFN99172
CAS No: 84680-75-1
Price: $50/20mg
Beta-boswellic acid

Catalog No: CFN90221
CAS No: 631-69-6
Price: $218/20mg
Dihydrotanshinone I

Catalog No: CFN97435
CAS No: 87205-99-0
Price: $60/20mg
6'''-Feruloylspinosin

Catalog No: CFN90665
CAS No: 77690-92-7
Price: $138/20mg
Hypericin

Catalog No: CFN99188
CAS No: 548-04-9
Price: $100/20mg
Pratensein

Catalog No: CFN90805
CAS No: 2284-31-3
Price: $388/5mg
Chikusetsusaponin IVa

Catalog No: CFN92516
CAS No: 51415-02-2
Price: $80/20mg
3-O-Acetyl-11-keto-beta-boswellic ...

Catalog No: CFN90531
CAS No: 67416-61-9
Price: $80/20mg
Kojic acid

Catalog No: CFN94478
CAS No: 501-30-4
Price: $40/20mg
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