• ChemFaces is a professional high-purity natural products manufacturer.
  • Product Intended Use
  • 1. Reference standards
  • 2. Pharmacological research
  • 3. Inhibitors
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • Bioactive Products
    Catalog No. Information
    CFN99514 Colchicine

    1. Colchicine prevents amyloidosis in our high-risk population and that it can prevent additional deterioration of renal function in patients with amyloidosis who have proteinuria but not the nephrotic syndrome.
    2. Colchicine binds at a location where it prevents curved tubulin from adopting a straight structure, which inhibits assembly, and microtubules are cytoskeletal polymers of tubulin involved in many cellular functions.
    3. Colchicine has anti-mitotic activity, it interacts with tubulin and perturbs the assembly dynamics of microtubules; though its use has been limited because of its toxicity, colchicine can still be used as a lead compound for the generation of potent anti-cancer drugs.
    4. Colchicine can treat familial mediterranean fever.
    5. Colchicine may exert its prophylactic effects on cytokine-provoked inflammation by diminishing the qualitative expression of E-selectin on endothelium, and its therapeutic effects by diminishing the quantitative expression of L-selectin on neutrophils.