1. Colchicine prevents amyloidosis in our high-risk population and that it can prevent additional deterioration of renal function in patients with amyloidosis who have proteinuria but not the nephrotic syndrome.
2. Colchicine binds at a location where it prevents curved tubulin from adopting a straight structure, which inhibits assembly, and microtubules are cytoskeletal polymers of tubulin involved in many cellular functions.
3. Colchicine has anti-mitotic activity, it interacts with tubulin and perturbs the assembly dynamics of microtubules; though its use has been limited because of its toxicity, colchicine can still be used as a lead compound for the generation of potent anti-cancer drugs.
4. Colchicine can treat familial mediterranean fever.
5. Colchicine may exert its prophylactic effects on cytokine-provoked inflammation by diminishing the qualitative expression of E-selectin on endothelium, and its therapeutic effects by diminishing the quantitative expression of L-selectin on neutrophils.