1. (+)-Gallocatechin as a bio-antimutagenic compound against UV-induced mutation in Escherichia coli.
2. (+)-Gallocatechin is potent in scavenging Fremy’s salt, a synthetic free radical, it possesses antioxidant capacities that is higher or comparable to that of ascorbic acid or Trolox.
1. Hispidulin has anti-oxidative, anti-inflammatory and anti-cancer activities, it can alleviate methamphetamine-induced hyperlocomotion without motor impairment in mice, suggesting a therapeutic potential of Hispidulin in hyper-dopaminergic disorders.
2. Hispidulin exerts anti-osteoporotic and bone resorption attenuating effects via activating the AMPK signaling pathway.
3. Hispidulin sensitizes the tumor cells to Gemcitabine and 5-Fluoroucil by down-regulating HIF-1α/P-gp signaling, it appears to be a promising and novel chemosensitizer for gallbladder cancer treatment.
4. Hispidulin has considerable antiepileptic, neuroprotective, and antiinflammatory effects on kainic acid-induced seizures in rats.
5. Hispidulin can ameliorate high glucose-mediated endothelial dysfunction via inhibiting PKCβII-associated NLRP3 inflammasome activation and NF-κB signaling, it has potential application in the prevention and treatment of diabetic vascular complications.
6. Hispidulin targets the VEGF receptor 2-mediated PI3K/Akt/mTOR signaling pathway in endothelial cells, leading to the suppression of pancreatic tumor growth and angiogenesis.
7. Hispidulin can inhibit platelet aggregation by elevating cAMP levels by a mechanism different from that of theophylline or PGE1.
1. Zingerone has been known as anti-mutagenic and anti-carcinogenic activities that are often associated with its anti-oxidative and anti-inflammatory activities.
2. Zingerone attenuates lipopolysaccharide-induced acute lung injury in mice.
3. Zingerone effectively inhibits 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in male Wistar rats.
4. Zingerone can inhibit biofilm formation and improve antibiofilm efficacy of ciprofloxacin against Pseudomonas aeruginosa PAO1, it could as potential phytotherapeutic agent which in future can be employed to formulate preventive strategies against biofilm associated infections caused by P.aeruginosa.
5. Zingerone can be recommended as a supplement to shrimp feed to increase growth, immunity, and disease resistance against the pathogen, V.alginolyticus , use of zingerone as appetizer and immunostimulant in shrimp is promising.
6. Zingerone appears to produce less lipolytic actions in adipocytes derived from the High Fat Diet (HFD)-fed rats, it may has anti-obesity actions.
1. Dictamnine and gamma-fagarine have mutagenic activities, they have specific activities (His+/microgram) of about 50-70 revertant colonies in strain TA100, while in strain TA98 there were about 30-50 revertant colonies.
2. Dictamnine has good antifungal activity alone and in combination with fluconazole against Candida albicans.
3. Dictamnine at higher concentrations(≥100uM) has potential hepatotoxicity, the cell membrane damage and mitochondrial membrane damage may be involved in the dictamnine-induced hepatotoxity mechanism.
4. Dictamnine has photoinduced genotoxicity.
5. Dictamnine shows anti-inflammatory effect.
6. Dictamnine shows anticholinesterase activityt.
1. Falcarindiol has antimutagenic activity, can suppress the mutagenicity of furylfuramide and 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1).
2. Falcarindiol inhibits nitric oxide-mediated neuronal death in lipopolysaccharide-treated organotypic hippocampal cultures, it has neuroprotective activity.
3. Falcarindiol has inhibitory activity against human gastric adenocarcinoma (MK-1) cell growth.
4. Falcarindiol has protective effects against CCl(4) toxicity, in part, the effects might be explained by anti-lipid peroxidation activity associated with the induction of the GSTs including GSTA4.
5. Falcarindiol has antifungal activity.
6. Falcarindiol can strongly inhibit the growth of Micrococcus luteus and Bacillus cereus, with a minimum inhibitory concentration (MIC) value of 50 microg ml(-1), and it shows cytotoxicity against IEC-6 cells,suggests that it could be potentially used in food manufactures and cosmetology as preservative agents and biopesticides, or in medicine as new antibiotics.
7. Falcarindiol is a potential new anticancer agent that exerts its activity through inducing ER stress and apoptosis.