1. (-)-Huperzine A is a naturally occurring potent reversible AChE inhibitor that penetrates the blood-brain barrier.
2. (-)-Huperzine A can be used as a protectIve agent against lethal dose nerve agent toxicity in guinea pigs.
3. A combination of (+) and (-)-Huperzine A offers better protection than (+)-Hup A.
1. Huperzine-B is a efficient inhibitor of human brain AChE.
2. Huperzine-B can enhance ognitive and protect neuro, may be potentially new drug candidates for Alzheimer's disease therapy.
1. Huperzine has the value as pretreatment of organophosphate poisoning, it can be used as a protective agent against organophosphate intoxication.