Science | Nature | Cell | View More
Bioactive Products
Anticancer Compound Library
A unique collection of 674 anticancer natural compounds for high throughput screening (HTS) and New anticancer drug research
Catalog No: B91 Anticancer Compound Library
Screening Details
Size: 1mg/well * 674 Compounds
2mg/well * 674 Compounds
Cat. No. Information
CFN99356 Cannabidiolic acid

Cannabidiolic acid inhibits migration of the highly invasive MDA-MB-231 human breast cancer cells, apparently through a mechanism involving inhibition of cAMP-dependent protein kinase A, coupled with an activation of the small GTPase, RhoA. Cannabidiolic acid displays significantly greater potency at inhibiting vomiting in shrews and nausea in rats, and at enhancing 5-HT(1A) receptor activation; it also selectively inhibits cyclooxygenase (COX)-2 activity with an IC(50) value around 2 microM, has 9-fold higher selectivity than COX-1 inhibition. Cannabidiolic acid and cannabidiol have inhibitory actions on the intestines of S. murinus that are not neuronallymediated or mediated via CB1 or CB2 receptors.
CFN99381 Taraxerol

Taraxerol can be used as a lipid biomarker for mangrove input to the SE Atlantic. Taraxerol has potent anti-inflammatory effects,it downregulates the expression of proinflammatory mediators in macrophages by interfering with the activation of TAK1 and Akt, thus preventing NF-κB activation. Taraxerol also has anti-cancer activity, it shows inhibitory effects on AGS cell growth through inducing G2/M arrest and promotion of cell apoptosis, taraxeryl acetate has less effect on cell cycle arrest and apoptosis of AGS cells than taraxerol.
CFN99394 Paulownin

Paulownin has the action of anti-inflammation,analgesia,immunity,hypoglycemia and has little toxicity. Paulownin demonstrates inhibitory activities against H. pylori Cystathionine gamma- synthase (HpCGS) with IC50 values of 19 +/- 2 microM, it can highly inhibit the growth of H. pylori and exhibit strong inhibitory specificity against H. pylori related to E. coli. (+)-Paulownin is active against the MCF-7 breast cancer cell line with IC50 values of 14.0 uM.
CFN99395 alpha-Terthienylmethanol

Alpha-terthienylmethanol possesses potent cytotoxic activity against human endometrial cancer cells; it inhibits growth mediated by the induction of apoptosis, as shown by the accumulation of sub-G1 and apoptotic cells.
CFN99399 Protopine

Protopine acts as a potent inhibitor of thromboxane synthesis and PAF with hepatoprotective, antidepressant, antioxidant, antispasmodic and relaxant properties. Protopine is also a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines. Protopine blocks phosphorylation of mitogen-activated protein kinases (MAP kinases) and also blocks activation of a nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB).