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Bioactive Products
Cat. No. Information
CFN00120 Janolusimide

Janolusimide is a neurotoxin and atropine antagonist.
CFN00121 Lactacystin

Lactacystin is a selective UPS inhibitor recently used to destroy dopamine (DA) neurons in animal models of Parkinson's disease (PD); marked differences in the rotational response to apomorphine and l-DOPA suggest different mechanisms of neurodegeneration evoked by Lactacystin and 6-OHDA. Lactacystin induces cell death and α-synuclein-positive inclusions in cytoplasm, it has diversified killing effects on gastric cancer cells, the mechanism may be related to induce the apoptosis by downregulation of nuclear factor kappa B viability.
CFN00433 Trichodesmine

Trichodesmine has greater lethality and neurotoxicity than monocrotaline, because of the two structural characteristics:(a) steric hindrance at position 14 of dehydroTrichodesmine results in greater resistance to hydrolysis, allowing more to be released from the liver and to be delivered to the brain;(b) the larger isopropyl substituent at position 14 of dehydroTrichodesmine renders the molecule more lipophilic, leading to greater penetration of the brain.
CFN90413 Dencichin

Dencichine is a haemostatic agent present, it is also a reported neurotoxic agent found in Lathyrus sativus (grass pea seed).
CFN90585 Dihydrorotenone

Dihydrorotenone is a potent mitochondrial inhibitor and probably induces Parkinsonian syndrome. It induces human plasma cell apoptosis by provoking endoplasmic reticulum stress and induces cell death by activating the p38 but not the JNK signaling pathway.