Science | Nature | Cell | View More
Natural Products
1-Caffeoylquinic acid
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 1-Caffeoylquinic acid
Price: $350 / 10mg
CAS No.: 1241-87-8
Catalog No.: CFN99121
Molecular Formula: C16H18O9
Molecular Weight: 354.31 g/mol
Purity: >=98%
Type of Compound: Phenylpropanoids
Physical Desc.: White powder
Source: The herb of Lonicera japonica Thunb.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $175.7 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of Stirling (United Kingdom)
  • Chulalongkorn University (Thailand)
  • Korea Food Research Institute(K... (Korea)
  • University of Virginia (USA)
  • Utah State University (USA)
  • Leibniz-Institut für Pflanzenb... (Germany)
  • Shanghai Institute of Organic C... (China)
  • University of Otago (New Zealand)
  • Calcutta University (India)
  • University of Auckland (New Zealand)
  • National Chung Hsing University (Taiwan)
  • More...
Package
Featured Products
Phyllanthin

Catalog No: CFN99050
CAS No: 10351-88-9
Price: $288/10mg
Neocryptotanshinone

Catalog No: CFN92181
CAS No: 109664-02-0
Price: $398/10mg
Pinostrobin chalcone

Catalog No: CFN99878
CAS No: 18956-15-5
Price: $368/20mg
Moracin D

Catalog No: CFN97179
CAS No: 69120-07-6
Price: $ /
Physalin B

Catalog No: CFN92941
CAS No: 23133-56-4
Price: $ / mg
Baicalin

Catalog No: CFN99111
CAS No: 21967-41-9
Price: $40/20mg
Robinin

Catalog No: CFN98375
CAS No: 301-19-9
Price: $318/5mg
Tanshinone IIA

Catalog No: CFN98952
CAS No: 568-72-9
Price: $30/20mg
Ginsenoside F1

Catalog No: CFN99754
CAS No: 53963-43-2
Price: $90/20mg
Kojic acid

Catalog No: CFN94478
CAS No: 501-30-4
Price: $40/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 1-Caffeoylquinic acid is an important intermediate in lignin biosynthesis. 1-Caffeoylquinic acid has anti-influenza, and antioxidant activities, it also slows the release of glucose into the bloodstream after a meal.
Targets: NF-kB
In vitro:
J Agric Food Chem. 2013 Nov 6;61(44):10507-15.
Qualitative and quantitative analysis of phenolics in Tetrastigma hemsleyanum and their antioxidant and antiproliferative activities.[Pubmed: 24151872]
The phenolic profiles of Tetrastigma hemsleyanum leaf extracts by different solvents (80% methanol, ethyl acetate and hexane) and their antioxidant and antiproliferative activities were investigated.
METHODS AND RESULTS:
Thirteen phenolic compounds (3-caffeoylquinic acid, 5-caffeoylquinic acid, 1-Caffeoylquinic acid, 5-p-coumaroylquinic acid, isoorientin-2″-O-rhamnoside, isoorientin, orientin-2″-O-rhamnoside, orientin, 1-p-coumaroylquinic acid, vitexin-2″-O-rhamnoside, isovitexin-2″-O-rhamnoside, vitexin and isovitexin) were identified in T. hemsleyanum leaves for the first time, and six of them were quantified using a combination of LC-QTOF-MS and LC-QqQ-MS techniques. It was found that 80% methanol extract exhibited the highest antioxidant activities.
CONCLUSIONS:
This paper provides a complete picture of phenolics in T. hemsleyanum leaves and relates them to their antioxidant and antiproliferative activities.
Anal Biochem . 2018 Apr 15;547:52-56.
PD-1/PD-L1 inhibitor screening of caffeoylquinic acid compounds using surface plasmon resonance spectroscopy[Pubmed: 29428377]
Abstract Following the FDA approval of three monoclonal antibodies of PD-1/PD-L1, this pathway has become a promising target for cancer treatment. Currently small-molecule inhibitors have not been extensively investigated, and appropriate screening methods for such inhibitors are urgently required. In this study, surface plasmon resonance (SPR) technology was used to evaluate the affinity and competitive inhibition of nine caffeoylquinic acid compounds (CQAs) against PD-1/PD-L1. As a result, four small molecules including 1-CQA, 3-CQA, 4-CQA and 5-CQA were determined as PD-1/PD-L1 inhibitors. This study provided an efficient method for screening small-molecule inhibitors targeting PD-1/PD-L1 pathway. Keywords: Caffeoylquinic acid compounds; PD-1; PD-L1; Small-molecule inhibitors; Surface plasmon resonance.
In vivo:
BMC Complement Altern Med . 2017 Jun 17;17(1):320.
Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd. Ameliorates hyperuricemia and acute gouty arthritis in animal model[Pubmed: 28623927]
Abstract Background: The Gnaphalium pensylvanicum willd. is used in China as a folk medicine to treat anti-inflammatory, cough and rheumatism arthritis. The aim of this study was to evaluate the potential of the extract of G. pensylvanicum to treat hyperuricemia and acute gouty arthritis in animal model. Methods: G. pensylvanicum extract was evaluated in an experimental model with potassium oxonate (PO) induced hyperuricemia in mice which was used to evaluate anti-hyperuricemia activity and xanthine oxidase (XO) inhibition. Therapies for acute gouty arthritis was also investigated on monosodium urate (MSU) crystal induced paw edema model. Results: G. pensylvanicum extract showed activity in reducing serum uric acid (Sur) through effect renal glucose transporter 9 (GLUT9), organic anion transporter 1 (OAT1) and urate transporter 1 (URAT1) mainly and inhibited XO activity in vivo of mice with PO induced hyperuricemia. The extract of G. pensylvanicum also showed significant anti-inflammatory activity and reduced the paw swelling on MSU crystal-induced paw edema model. Meanwhile, 13 caffeoylquinic acid derivatives and 1 flavone were identified by UPLC-ESI-MS/MS as the main active component of G. pensylvanicum. Conclusions: The extract of G. pensylvanicum showed significant effect on evaluated models and therefore may be active agents for the treatment of hyperuricemia and acute gouty arthritis. Keywords: Acute gouty arthritis; Caffeoylquinic acid derivatives; Gnaphalium pensylvanicum Willd.; Hyperuricemia; Pro-inflammatory cytokines; Xanthine oxidase.
1-Caffeoylquinic acid Description
Source: The herb of Lonicera japonica Thunb.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Glyasperin C

Catalog No: CFN95065
CAS No: 142474-53-1
Price: $333/5mg
cis-Mulberroside A

Catalog No: CFN95006
CAS No: 166734-06-1
Price: $418/10mg
Isosilychristin

Catalog No: CFN95369
CAS No: 77182-66-2
Price: $318/5mg
New compound 5

Catalog No: CFN95258
CAS No: N/A
Price: $413/5mg
Genistein 7-O-beta-D-glucopyranosi...

Catalog No: CFN95159
CAS No: 70404-42-1
Price: $318/10mg
Tectorigenin 7-O-gentiobioside

Catalog No: CFN95577
CAS No: 67604-94-8
Price: $318/5mg
1-Isomangostin

Catalog No: CFN95114
CAS No: 19275-44-6
Price: $318/5mg
Nortrachelogenin-5'-C-beta-glucosi...

Catalog No: CFN95251
CAS No: 858127-39-6
Price: $318/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8224 mL 14.1119 mL 28.2239 mL 56.4477 mL 70.5597 mL
5 mM 0.5645 mL 2.8224 mL 5.6448 mL 11.2895 mL 14.1119 mL
10 mM 0.2822 mL 1.4112 mL 2.8224 mL 5.6448 mL 7.056 mL
50 mM 0.0564 mL 0.2822 mL 0.5645 mL 1.129 mL 1.4112 mL
100 mM 0.0282 mL 0.1411 mL 0.2822 mL 0.5645 mL 0.7056 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Pharmacogn Mag. 2013 Jan;9(33):51-7.
Dietary phytochemicals as potent chemotherapeutic agents against breast cancer: Inhibition of NF-κB pathway via molecular interactions in rel homology domain of its precursor protein p105.[Pubmed: 23661994]
Dietary phytochemicals consist of a wide variety of biologically active compounds that are ubiquitous in plants, many of which have been reported to have anti-tumor as well as anti-inflammatory properties. In the present study, we aimed to validate these findings by using docking protocols and explicate the possible mechanism of action for a dataset of nine phytochemicals namely boswellic acid, 1-Caffeoylquinic acid, ellagic acid, emodin, genistein, guggulsterone, quercetin, resveratrol, and sylibinin from different plants against the nuclear factor- kappaB (NF-κB) precursor protein p105, an important transcription factor reported to be overexpressed in breast cancer.
METHODS AND RESULTS:
2-D structures of all phytochemicals were retrieved from PubChem Compound database and their subsequent conversion into 3-D structures was performed by using online software system CORINA. The X-ray crystallographic structure of the NF-κB precursor p105 was extracted from Brookhaven Protein Data Bank. Molecular docking simulation study was carried out by using AutoDock Tools 4.0. Our results showed significant binding affinity of different phytochemicals with the Rel homology domain of the NF-κB precursor protein p105. Quercetin and 1-Caffeoylquinic acid were found to be very effective inhibitors against target molecule as they showed binding energy of -12.11 and -11.50 Kcal/mol, respectively. The order of affinity of other ligands with p105 was found as follows: guggulsterone > sylibinin > emodin > resveratrol > genistein > boswellic acid > ellagic acid.
CONCLUSIONS:
Our in silico study has explored the possible chemopreventive mechanism of these phytochemicals against the NF-κB precursor protein p105 and deciphered that quercetin, 1-Caffeoylquinic acid and guggulsterone were the potent inhibitors against target molecule. In addition, large scale preclinical and clinical trials are needed to explore the role of these chemotherapeutic molecules against the NF-κB precursor protein p105 in cure and prevention of breast cancer.
Phyllanthin

Catalog No: CFN99050
CAS No: 10351-88-9
Price: $288/10mg
Neocryptotanshinone

Catalog No: CFN92181
CAS No: 109664-02-0
Price: $398/10mg
Pinostrobin chalcone

Catalog No: CFN99878
CAS No: 18956-15-5
Price: $368/20mg
Moracin D

Catalog No: CFN97179
CAS No: 69120-07-6
Price: $ /
Physalin B

Catalog No: CFN92941
CAS No: 23133-56-4
Price: $ / mg
Baicalin

Catalog No: CFN99111
CAS No: 21967-41-9
Price: $40/20mg
Robinin

Catalog No: CFN98375
CAS No: 301-19-9
Price: $318/5mg
Tanshinone IIA

Catalog No: CFN98952
CAS No: 568-72-9
Price: $30/20mg
Ginsenoside F1

Catalog No: CFN99754
CAS No: 53963-43-2
Price: $90/20mg
Kojic acid

Catalog No: CFN94478
CAS No: 501-30-4
Price: $40/20mg
Tags: buy 1-Caffeoylquinic acid | 1-Caffeoylquinic acid supplier | purchase 1-Caffeoylquinic acid | 1-Caffeoylquinic acid cost | 1-Caffeoylquinic acid manufacturer | order 1-Caffeoylquinic acid | 1-Caffeoylquinic acid distributor