|Source:||The barks of Picrasma quassioides|
|Biological Activity or Inhibitors:||1. Combination of 1-acetyl-beta-carboline with ampicillin exhibits synergistic antibacterial activity against MRSA.
|Solvent:||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||4.7574 mL||23.7869 mL||47.5737 mL||95.1475 mL||118.9343 mL|
|5 mM||0.9515 mL||4.7574 mL||9.5147 mL||19.0295 mL||23.7869 mL|
|10 mM||0.4757 mL||2.3787 mL||4.7574 mL||9.5147 mL||11.8934 mL|
|50 mM||0.0951 mL||0.4757 mL||0.9515 mL||1.9029 mL||2.3787 mL|
|100 mM||0.0476 mL||0.2379 mL||0.4757 mL||0.9515 mL||1.1893 mL|
J Microbiol Biotechnol. 2010 Mar;20(3):501-5.
|The synergistic antibacterial activity of 1-acetyl-beta-carboline and beta-lactams against methicillin-resistant Staphylococcus aureus (MRSA).[Pubmed: 20372018]|
|1-Acetyl-beta-carboline was isolated as an anti-MRSA agent from the fermentation broth of a marine actinomycete isolated from marine sediment. The producing strain was identified to be Streptomyces sp. by phylogenetic analysis of the 16S rRNA gene sequence. The anti-MRSA agent was isolated by bioactivity-guided fractionation of the culture extract by solvent partitioning, ODS open flash chromatography, and purification with a reversed-phase HPLC. Its structure was elucidated by extensive 2D NMR and mass spectral analyses. Combination of 1-Acetyl-beta-carboline with ampicillin exhibited synergistic antibacterial activity against MRSA.|