10-Deacetylbaccatin III | CAS:32981-86-5

10-Deacetylbaccatin III

ChemFaces products have been cited in many studies from excellent and top scientific journals

Product Name	10-Deacetylbaccatin III
Price:	$30 / 20mg
CAS No.:	32981-86-5
Catalog No.:	CFN98421
Molecular Formula:	C₂₉H₃₆O₁₀
Molecular Weight:	544.6 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The barks of Taxus yunnanensis Cheng et L. K. Fu
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $14.0 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Our products had been exported to the following research institutions and universities, And still growing.

Uniwersytet Medyczny w ?odzi (Poland)
Biotech R&D Institute (USA)
Instituto Politécnico de Bragan?a (Portugal)
University of Melbourne (Australia)

Seoul National University of Sc... (Korea)
Korea Intitute of Science and T... (Korea)
University of East Anglia (United Kingdom)
University of Toulouse (France)

Universidad Veracuzana (Mexico)
Universidad de La Salle (Mexico)
Texas A&M University (USA)
More...

Package

Featured Products

More...

Vitexin-2''-O-rhamnoside

Catalog No: CFN98177
CAS No: 64820-99-1
Price: $118/20mg

Kaempferol-3-beta-O-glucuronide

Catalog No: CFN90359
CAS No: 22688-78-4
Price: $318/5mg

Oxypeucedanin hydrate

Catalog No: CFN90557
CAS No: 2643-85-8
Price: $80/20mg

Quercetin 3-O-glucoside-7-O-rhamno...

Catalog No: CFN90738
CAS No: 18016-58-5
Price: $538/5mg

Harpagoside

Catalog No: CFN98147
CAS No: 19210-12-9
Price: $70/20mg

Adenosine

Catalog No: CFN98992
CAS No: 58-61-7
Price: $30/20mg

4-Hydroxybenzoic acid

Catalog No: CFN97577
CAS No: 99-96-7
Price: $30/20mg

Luteolin 7-diglucuronide

Catalog No: CFN70468
CAS No: 96400-45-2
Price: $ / mg

Kojic acid

Catalog No: CFN94478
CAS No: 501-30-4
Price: $40/20mg

Vanillic acid

Catalog No: CFN99331
CAS No: 121-34-6
Price: $30/20mg

Description:

10-Deacetylbacccatin III is an antineoplastic agent and an anti-cancer intermediate, it can selectively inhibit the growth of L. donovani intracellular amastigotes within J774 murine macrophages in vitro at nanomolar concentrations with an IC50 value of 70 nM. The 10-Deacetylbaccatin III-treated promastigotes were slightly arrested in the G2/M phase whereas taxol-treated cells were blocked in the G2/M phase.

In vitro:

Planta Med. 2007 Aug;73(10):1081-8.

In vitro activity of 10-deacetylbaccatin III against Leishmania donovani promastigotes and intracellular amastigotes.[Pubmed: 17691059]

Current treatments for leishmaniasis are unsatisfactory due to their route of administration, toxicity and expense but, most importantly, to the developed resistance of Leishmania to first-line drugs. Therefore, the identification of new effective targeted drugs is an urgent need. Since many studies have shown that medicinal plants contain compounds active against protozoa we have undertaken a study aiming to determine the antileishmanial activity of the taxoid 10-Deacetylbaccatin III, isolated from dried needles and small branches of the European yew tree (Taxus baccata).
METHODS AND RESULTS:
Interestingly, 10-Deacetylbaccatin III was found to selectively inhibit the growth of L. DONOVANI intracellular amastigotes within J774 murine macrophages in vitro at nanomolar concentrations with an IC(50) value of 70 nM. Concentrations of 10-Deacetylbaccatin III as high as 5 microM did not affect J774 murine macrophages whereas 20 nM of taxol, used as a control, was toxic to macrophages. The compound also inhibited the growth of L. donovani promastigotes but at higher concentrations with a maximum level of inhibition of 35 %. Taxol inhibited promastigote growth at micromolar concentrations. Comparison of the effect of 10-Deacetylbaccatin III to that of taxol on cell cycle progression and cellular morphology showed that their mechanisms of action are different.
METHODS AND RESULTS:
The 10-Deacetylbaccatin III-treated promastigotes were slightly arrested in the G2/M phase whereas taxol-treated cells were blocked in the G2/M phase. In addition 10-Deacetylbaccatin III treatment, contrary to taxol, did not affect cellular morphology.

10-Deacetylbaccatin III Description

Source:	The barks of Taxus yunnanensis Cheng et L. K. Fu
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Cell Research:

Yao Xue Xue Bao. 1998;33(2):132-7.

Effects of phenylalanine, sucrose and mannitol on the growth and production of taxol, baccatin III and 10-deacetylbaccatin III in suspension cells of Taxus media.[Pubmed: 11938949]

The effects of phenylalanine, sucrose and mannitol on the cell growth and the production of taxol, baccatin III and 10-Deacetylbaccatin III in the suspension cells of Taxus media were studied.
METHODS AND RESULTS:
The results showed that phenylalanine 1.0 mmol.L-1 or 2.0 mmol.L-1 initially added into the medium, and sucrose 73.0 mmol.L-1 and mannitol 173.3 mmol.L-1 added into the medium at the 28th d of culture strongly promoted the cell growth and the formation of the three taxanes in the suspension cells. Compared with those of the control, the cell biomass of the treatments supplemented with phenylalanine and added with sucrose and mannitol at the 28th d of culture increased by 0.6-0.8-fold, taxol yield by 9-10-fold, baccatin III yield by 2.5-3.0-fold, and 10-Deacetylbaccatin III yield by 7-fold. Addition of sucrose 73.0 mmol.L-1 at the 28th d of culture significantly promoted the cell growth, but showed little effect on the contents of the three taxanes in the suspension cultures.

Structure Identification:

Biol Chem Hoppe Seyler. 1994 Apr;375(4):281-7.

Immunological detection and quantitation of 10-deacetylbaccatin III in Taxus sp. plant and tissue cultures.[Pubmed: 8060537]

A high-sensitive ELISA method was developed for the detection and semi-quantitative determination of 10-Deacetylbaccatin III and its structurally related compounds in crude extract of Taxus sp. plants and tissue cultures.
METHODS AND RESULTS:
The antibodies were raised in rabbits using 7- or 10-succinyl-10-Deacetylbaccatin III-BSA conjugate as immunogen. The working range of the assay was from 0.003 to 1.000 ng (0.09 to 31.33 nM) of 10-Deacetylbaccatin III per assay. The cross-reacting material in crude plant extract was examined by chromatographic (silica gel CC, HPLC) and immunoassay methods. Study on the evaluation of cross-reacting material in crude Taxus plant extracts showed that at least 80% of the immunosignal correspond to 10-Deacetylbaccatin III in the extract. The ELISA method was applied to investigate the 10-Deacetylbaccatin III equivalent content in crude extracts of 19 plants species including Taxaceae, Taxodiaceae and Pinaceae species. The 10-Deacetylbaccatin III-like structure was only detected in Taxus and Torreya sp.
CONCLUSIONS:
The results indicate that this immunoassay is a useful tool for the rapid screening of species, varieties or individual plants out of a wide population. The distribution of 10-Deacetylbaccatin III equivalent content in 9-month old Taxus plantlets cultivated in vitro as well as in callus culture was investigated.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Precursors Compound Library Antiparasitic Compound Library Diterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.8362 mL	9.1811 mL	18.3621 mL	36.7242 mL	45.9053 mL
5 mM	0.3672 mL	1.8362 mL	3.6724 mL	7.3448 mL	9.1811 mL
10 mM	0.1836 mL	0.9181 mL	1.8362 mL	3.6724 mL	4.5905 mL
50 mM	0.0367 mL	0.1836 mL	0.3672 mL	0.7345 mL	0.9181 mL
100 mM	0.0184 mL	0.0918 mL	0.1836 mL	0.3672 mL	0.4591 mL

CFN89062	9-Dihydro-13-acetylbaccatin III	142203-65-4	630.68	C₃₃H₄₂O₁₂
CFN96925	Baccatin VI	57672-79-4	714.76	C₃₇H₄₆O₁₄
CFN96907	Baccatin VIII	1623410-10-5	646.68	C₃₃H₄₂O₁₃
CFN98976	Baccatin IV	57672-77-2	652.7	C₃₂H₄₄O₁₄
CFN98421	10-Deacetylbaccatin III	32981-86-5	544.6	C₂₉H₃₆O₁₀
CFN98331	Baccatin III	27548-93-2	586.6	C₃₁H₃₈O₁₁
CFN97267	19-Hydroxybaccatin III	78432-78-7	602.6	C₃₁H₃₈O₁₂
CFN89390	7-Xylosyl-10-deacetylbaccatin III	157664-03-4	676.70	C₃₄H₄₄O₁₄
CFN96908	Baccatin IX	1623410-12-7	604.64	C₃₁H₄₀O₁₂
CFN96909	Baccatin X	1623069-76-0	604.64	C₃₁H₄₀O₁₂