Science | Nature | Cell | View More
Natural Products
14-Deoxy-12-hydroxyandrographolide
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 14-Deoxy-12-hydroxyandrographolide
Price:
CAS No.: 219721-33-2
Catalog No.: CFN97785
Molecular Formula: C20H30O5
Molecular Weight: 350.45 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The herbs of Andrographis paniculata (Burm. f.) Nees
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Ateneo de Manila University (Philippines)
  • Kyoto University (Japan)
  • Northeast Normal University Cha... (China)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • University of Parma (Italy)
  • Kitasato University (Japan)
  • Research Unit Molecular Epigene... (Germany)
  • Monash University Sunway Campus (Malaysia)
  • Sri Sai Aditya Institute of Pha... (India)
  • University of Padjajaran (Indonesia)
  • University of Wisconsin-Madison (USA)
  • More...
Package
Featured Products
Withaferin A

Catalog No: CFN91895
CAS No: 5119-48-2
Price: $298/20mg
1-O-Acetylbritannilactone

Catalog No: CFN89438
CAS No: 33627-41-7
Price: $218/20mg
Theaflavin 3,3'-di-O-gallate

Catalog No: CFN99130
CAS No: 30462-35-2
Price: $268/20mg
Higenamine

Catalog No: CFN93353
CAS No: 5843-65-2
Price: $80/20mg
Sesamoside

Catalog No: CFN99274
CAS No: 117479-87-5
Price: $100/20mg
5-O-Feruloylquinic acid

Catalog No: CFN92889
CAS No: 40242-06-6
Price: $318/10mg
Pectolinarigenin

Catalog No: CFN99010
CAS No: 520-12-7
Price: $138/20mg
Scopolin

Catalog No: CFN98887
CAS No: 531-44-2
Price: $80/20mg
Orientin

Catalog No: CFN98136
CAS No: 28608-75-5
Price: $70/20mg
Ganoderenic acid D

Catalog No: CFN90300
CAS No: 100665-43-8
Price: $368/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Standard reference
Targets: Antifection
In vitro:
Nat Prod Commun. 2012 Apr;7(4):485-6.
A new diterpene from the leaves of Andrographis paniculata Nees.[Pubmed: 22574448]

METHODS AND RESULTS:
Phytochemical investigation of the methanolic extract of the leaves of Andrographis paniculata Nees yielded a minor, new diterpene, 21-nor-3,19-isopropylidine-14-deoxy-ent-labda-8(17),13-dien-16,15-olide (1), together with five known labdane type diterpenes, andrographolide 3, 14-deoxyandrographolide 4, 14-Deoxy-12-hydroxyandrographolide 5, 14-deoxy-11,12-dihydroandrographolide 6, neoandrographolide 7, and two acids, cinnamic acid 8, and ferulic acid 9. The chemical structures were established by spectroscopic analyses, including 1D- and 2D-NMR spectroscopic experiments, and on the basis of HR-ESI MS analyses.
CONCLUSIONS:
The methanolic extract of the leaves exhibited moderate antibacterial and antifungal activities at a dose of 200 microg/mL in comparison with the reference standards.
In vivo:
J Biomed Biotechnol. 2012;2012:876458.
Cardiovascular activity of labdane diterpenes from Andrographis paniculata in isolated rat hearts.[Pubmed: 22536026]
The dichloromethane (DCM) extract of Andrographis paniculata Nees was tested for cardiovascular activity.
METHODS AND RESULTS:
The extract significantly reduced coronary perfusion pressure by up to 24.5 ± 3.0 mm Hg at a 3 mg dose and also reduced heart rate by up to 49.5 ± 11.4 beats/minute at this dose. Five labdane diterpenes, 14-Deoxy-12-hydroxyandrographolide (1), 14-deoxy-11,12-didehydroandrographolide (2), 14-deoxyandrographolide (3), andrographolide (4), and neoandrographolide (5), were isolated from the aerial parts of this medicinal plant.
CONCLUSIONS:
Bioassay-guided studies using animal model showed that compounds, (2) and (3) were responsible for the coronary vasodilatation. This study also showed that andrographolide (4), the major labdane diterpene in this plant, has minimal effects on the heart.
14-Deoxy-12-hydroxyandrographolide Description
Source: The herbs of Andrographis paniculata (Burm. f.) Nees
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Cuscutamine

Catalog No: CFN95323
CAS No: 122170-93-8
Price: $318/5mg
Chamigrenol

Catalog No: CFN95247
CAS No: 19822-80-1
Price: $318/10mg
Yinxiancaoside C

Catalog No: CFN95377
CAS No: 1159908-74-3
Price: $413/5mg
Methyl nomilinate

Catalog No: CFN95576
CAS No: 77887-51-5
Price: $318/5mg
Ganoderenic acid K

Catalog No: CFN95469
CAS No: 942950-94-9
Price: $318/10mg
9-Hydroxy-O-senecioyl-8,9-dihydroo...

Catalog No: CFN95274
CAS No: 31456-63-0
Price: $318/5mg
Isoedultin

Catalog No: CFN95273
CAS No: 43043-08-9
Price: $318/5mg
8-Hydroxy-5,7-dimethoxyflavanone

Catalog No: CFN95580
CAS No: 201230-40-2
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8535 mL 14.2674 mL 28.5347 mL 57.0695 mL 71.3369 mL
5 mM 0.5707 mL 2.8535 mL 5.7069 mL 11.4139 mL 14.2674 mL
10 mM 0.2853 mL 1.4267 mL 2.8535 mL 5.7069 mL 7.1337 mL
50 mM 0.0571 mL 0.2853 mL 0.5707 mL 1.1414 mL 1.4267 mL
100 mM 0.0285 mL 0.1427 mL 0.2853 mL 0.5707 mL 0.7134 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Withaferin A

Catalog No: CFN91895
CAS No: 5119-48-2
Price: $298/20mg
1-O-Acetylbritannilactone

Catalog No: CFN89438
CAS No: 33627-41-7
Price: $218/20mg
Theaflavin 3,3'-di-O-gallate

Catalog No: CFN99130
CAS No: 30462-35-2
Price: $268/20mg
Higenamine

Catalog No: CFN93353
CAS No: 5843-65-2
Price: $80/20mg
Sesamoside

Catalog No: CFN99274
CAS No: 117479-87-5
Price: $100/20mg
5-O-Feruloylquinic acid

Catalog No: CFN92889
CAS No: 40242-06-6
Price: $318/10mg
Pectolinarigenin

Catalog No: CFN99010
CAS No: 520-12-7
Price: $138/20mg
Scopolin

Catalog No: CFN98887
CAS No: 531-44-2
Price: $80/20mg
Orientin

Catalog No: CFN98136
CAS No: 28608-75-5
Price: $70/20mg
Ganoderenic acid D

Catalog No: CFN90300
CAS No: 100665-43-8
Price: $368/20mg
Tags: buy 14-Deoxy-12-hydroxyandrographolide | 14-Deoxy-12-hydroxyandrographolide supplier | purchase 14-Deoxy-12-hydroxyandrographolide | 14-Deoxy-12-hydroxyandrographolide cost | 14-Deoxy-12-hydroxyandrographolide manufacturer | order 14-Deoxy-12-hydroxyandrographolide | 14-Deoxy-12-hydroxyandrographolide distributor