Science | Nature | Cell | View More
Natural Products
19-Oxocinobufotalin
19-Oxocinobufotalin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 19-Oxocinobufotalin
Price: $413 / 5mg
CAS No.: 24512-60-5
Catalog No.: CFN91016
Molecular Formula: C26H32O8
Molecular Weight: 472.53 g/mol
Purity: >=98%
Type of Compound: Steroids
Physical Desc.: Powder
Source: The glandular body of Bufo bufo gargarizans Cantor.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $318 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Periyar University (India)
  • Medical University of South Car... (USA)
  • University of Toronto (Canada)
  • Chulalongkorn University (Thailand)
  • University of Madras (India)
  • Chang Gung University (Taiwan)
  • The University of Newcastle (Australia)
  • University of Helsinki (Finland)
  • Leibniz Institute of Plant Bioc... (Germany)
  • University of Auckland (New Zealand)
  • Julius Kühn-Institut (Germany)
  • More...
Package
Featured Products
11-Hydroxy-sugiol

Catalog No: CFN90366
CAS No: 88664-08-8
Price: $490/5mg
Ginsenoside Rg3

Catalog No: CFN99969
CAS No: 14197-60-5
Price: $40/20mg
Withaferin A

Catalog No: CFN91895
CAS No: 5119-48-2
Price: $298/20mg
6''-O-Malonylgenistin

Catalog No: CFN90631
CAS No: 51011-05-3
Price: $348/5mg
11-Keto-beta-boswellic acid

Catalog No: CFN90152
CAS No: 17019-92-0
Price: $238/20mg
Feretoside

Catalog No: CFN98330
CAS No: 27530-67-2
Price: $268/10mg
Kuwanon G

Catalog No: CFN93278
CAS No: 75629-19-5
Price: $218/20mg
Trilobatin

Catalog No: CFN98658
CAS No: 4192-90-9
Price: $30/20mg
Genistin

Catalog No: CFN90250
CAS No: 529-59-9
Price: $40/20mg
Honokiol

Catalog No: CFN99902
CAS No: 35354-74-6
Price: $30/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 19-Oxocinobufotalin 3-adipoylarginine ester shows significant inhibition effect against human hepatocellular carcinoma cell line SMMC-7721 in vitro.
In vitro:
J Asian Nat Prod Res. 2011 Feb;13(2):111-6.
Cytotoxic constituents from the skin of the toad Bufo bufo gargarizans.[Pubmed: 21279874 ]

METHODS AND RESULTS:
To study the chemical composition of the skin of Bufo bufo gargarizans, various chromatographic methods were used in the isolation procedures and the structures of isolated compounds were determined based on NMR and MS analysis. As a result, two new compounds were isolated from its ethanolic extract and characterized as N-[2-hydroxy-2-(4-hydroxyphenyl)ethyl]-N-methylurea (1) and 19-Oxocinobufotalin 3-adipoylarginine ester (2), together with 11 known compounds.
CONCLUSIONS:
Isolated bufadienolides showed significant inhibition effect against human hepatocellular carcinoma cell line SMMC-7721 in vitro.
19-Oxocinobufotalin Description
Source: The glandular body of Bufo bufo gargarizans Cantor.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Isoformononetin

Catalog No: CFN95024
CAS No: 486-63-5
Price: $288/5mg
Oleuroside

Catalog No: CFN95099
CAS No: 116383-31-4
Price: $288/20mg
Buddlenoid A

Catalog No: CFN95025
CAS No: 142750-32-1
Price: $368/5mg
Ganoderic acid J

Catalog No: CFN95516
CAS No: 100440-26-4
Price: $318/10mg
Marginatoxin

Catalog No: CFN95174
CAS No: 1422536-56-8
Price: $318/10mg
2'-Rhamnoechinacoside

Catalog No: CFN95035
CAS No: 1422390-59-7
Price: $368/10mg
Batatasin V

Catalog No: CFN95320
CAS No: 65817-45-0
Price: $318/5mg
Gardenin D

Catalog No: CFN95133
CAS No: 29202-00-4
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1163 mL 10.5813 mL 21.1627 mL 42.3254 mL 52.9067 mL
5 mM 0.4233 mL 2.1163 mL 4.2325 mL 8.4651 mL 10.5813 mL
10 mM 0.2116 mL 1.0581 mL 2.1163 mL 4.2325 mL 5.2907 mL
50 mM 0.0423 mL 0.2116 mL 0.4233 mL 0.8465 mL 1.0581 mL
100 mM 0.0212 mL 0.1058 mL 0.2116 mL 0.4233 mL 0.5291 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Helvetica Chimica Acta, 1969, 52(4):1097–1101.
über neue Bufadienolide aus Ch'an Su. über Krötengifte, 34. Mitteilung.[Reference: WebLink]
Two new bufadienolides, isolated from Ch'an Su, are proved to be 19-Oxocinobufagin (III) and 19-Oxocinobufotalin (V), respectively.
11-Hydroxy-sugiol

Catalog No: CFN90366
CAS No: 88664-08-8
Price: $490/5mg
Ginsenoside Rg3

Catalog No: CFN99969
CAS No: 14197-60-5
Price: $40/20mg
Withaferin A

Catalog No: CFN91895
CAS No: 5119-48-2
Price: $298/20mg
6''-O-Malonylgenistin

Catalog No: CFN90631
CAS No: 51011-05-3
Price: $348/5mg
11-Keto-beta-boswellic acid

Catalog No: CFN90152
CAS No: 17019-92-0
Price: $238/20mg
Feretoside

Catalog No: CFN98330
CAS No: 27530-67-2
Price: $268/10mg
Kuwanon G

Catalog No: CFN93278
CAS No: 75629-19-5
Price: $218/20mg
Trilobatin

Catalog No: CFN98658
CAS No: 4192-90-9
Price: $30/20mg
Genistin

Catalog No: CFN90250
CAS No: 529-59-9
Price: $40/20mg
Honokiol

Catalog No: CFN99902
CAS No: 35354-74-6
Price: $30/20mg
Tags: buy 19-Oxocinobufotalin | 19-Oxocinobufotalin supplier | purchase 19-Oxocinobufotalin | 19-Oxocinobufotalin cost | 19-Oxocinobufotalin manufacturer | order 19-Oxocinobufotalin | 19-Oxocinobufotalin distributor