2',3,5,7-Tetrahydroxyflavone | CAS:480-15-9

2',3,5,7-Tetrahydroxyflavone

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2',3,5,7-Tetrahydroxyflavone Description

Source:	The roots of Kaempferia galangal L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Journal of Pharmacological Sciences, 21 May 2011, 116(2):221-231.

Effects of flavonoids on matrix metalloproteinase-13 expression of interleukin-1β-treated articular chondrocytes and their cellular mechanisms: inhibition of c-Fos/AP-1 and JAK/STAT signaling pathways.[Reference: WebLink]

To identify the therapeutic potential for cartilage degradation and its action mechanisms, the effects of naturally-occurring flavonoids on matrix metalloproteinase-13 (MMP-13) induction were examined in the human chondrocyte cell line SW1353.
METHODS AND RESULTS:
Flavones including apigenin and wogonin strongly inhibited MMP-13 induction in interleukin (IL)-1β-treated SW1353 cells, while flavonols such as kaempferol, quercetin, and flavanone (naringenin) did not at 5 - 25 µM. Apigenin and wogonin primarily inhibit MMP-13 by blocking the c-Fos / activator protein-1 (AP-1) and Janus kinase 2 (JAK2) / signal transducer and activator of transcription 1/2 (STAT1/2) pathways, but not nuclear factor-κB (NF-κB) signaling. Apigenin was also shown to inhibit extracellular matrix degradation in rabbit cartilage culture. The following study using some synthetic flavones demonstrated that A-ring C-5,7-dihydroxyl and B-ring dihydroxyl substitution at C-2,3, C-2,4, or C-3,4 are important for the suppression of MMP-13 expression. Among these flavones, 2',3,5,7-Tetrahydroxyflavone also inhibited both the c-Fos/AP-1 and STAT1/2 pathways.
CONCLUSIONS:
Taken together, these results indicate that certain flavonoids, especially flavones, inhibit MMP-13 expression in IL-1β-treated chondrocytes, at least in part, by suppressing the c-Fos/AP-1 and JAK2/STAT1/2 pathways. Furthermore, these findings suggest that some flavonoids have the potential for protecting against collagen matrix breakdown in the cartilage of diseased tissues such as those found in arthritic disorders.

Product Name	2',3,5,7-Tetrahydroxyflavone
Price:
CAS No.:	480-15-9
Catalog No.:	CFN70373
Molecular Formula:	C₁₅H₁₀O₆
Molecular Weight:	286.2 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The roots of Kaempferia galangal L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Flavonoids Compound Library STAT Inhibitor Library JAK Inhibitor Library AP-1 Inhibitor Library

Description:	2',3,5,7-Tetrahydroxyflavone inhibits MMP-13 expression in IL-1β-treated chondrocytes, at least in part, by suppressing the c-Fos/AP-1 and JAK2/STAT1/2 pathways.
Targets:	c-Fos \| AP-1 \| STAT \| MMP \| JAK \| IL Recepter

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.4941 mL	17.4703 mL	34.9406 mL	69.8812 mL	87.3515 mL
5 mM	0.6988 mL	3.4941 mL	6.9881 mL	13.9762 mL	17.4703 mL
10 mM	0.3494 mL	1.747 mL	3.4941 mL	6.9881 mL	8.7352 mL
50 mM	0.0699 mL	0.3494 mL	0.6988 mL	1.3976 mL	1.747 mL
100 mM	0.0349 mL	0.1747 mL	0.3494 mL	0.6988 mL	0.8735 mL

CFN93002	Isokaempferide	1592-70-7	300.3	C₁₆H₁₂O₆
CFN92510	Kaempferol 5-methyl ether	22044-80-0	300.3	C₁₆H₁₂O₆
CFN97724	Rhamnocitrin	569-92-6	300.27	C₁₆H₁₂O₆
CFN98782	Kaempferide	491-54-3	300.3	C₁₆H₁₂O₆
CFN98423	Kumatakenin	3301-49-3	314.3	C₁₇H₁₄O₆
CFN99651	3,5-Dihydroxy-4',7-dimethoxyflavone	15486-33-6	314.3	C₁₇H₁₄O₆
CFN98050	Ermanin	20869-95-8	314.3	C₁₇H₁₄O₆
CFN96191	Kaempferol 3,7,4'-trimethylether	15486-34-7	328.3	C₁₈H₁₆O₆
CFN96292	Kaempferol 5,7,4'-trimethyl ether	1098-92-6	328.3	C₁₈H₁₆O₆
CFN91889	Tetramethylkaempferol	16692-52-7	342.34	C₁₉H₁₈O₆