(2-Amino-1-hydroxyethyl)phosphonic acid | CAS:115511-00-7

(2-Amino-1-hydroxyethyl)phosphonic acid

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(2-Amino-1-hydroxyethyl)phosphonic acid Description

Source:	From Acanthamoeba castellanii
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Acs Catalysis, 2017:3521-3531.

Mechanism of Organophosphonate Catabolism by Diiron Oxygenase PhnZ: A Third Iron-Mediated O-O Activation Scenario in Nature.[Reference: WebLink]

Diiron oxygenase PhnZ catalyzes the catabolism of organophosphonate (Pn) (R)-2-amino-1-hydroxyethylphosphonic((2-Amino-1-hydroxyethyl)phosphonic acid) to glycine and inorganic phosphate (Pi).
METHODS AND RESULTS:
In this Pn catabolism way, PhnZ oxidatively cleaves the highly stable C-P bond in Pn to produce Pi. However, the mechanism of this enzyme that affords aquatic and marine bacteria in Pi-limited environments to utilize the most abundant environmental Pn (2-amino-ethylphosphonic acid) as the source of Pi, is still unclear. In this work, extensive QM/MM calculations reveal that the mechanism of PhnZ consists of four consecutive steps: (1) Rate-limiting α-H abstraction of Pn by FeIII-superoxo; (2) Formation of FeIIIOOCα peroxide; (3) Concerted O insertion into Cα-P bond of Pn initiated by “inverse” heterolytic O-O cleavage; (4) Phosphate hydrolysis to glycine and Pi. Intriguingly, the enzymatic reaction mechanism of PhnZ for the crucial breakage of the C-P bond is characterized by the “inverse” heterolytic O-O cleavage of FeIIIOOCα intermediate, which renders the distal O atom more oxidative to oxygenate Pn than the homolytic O-O cleavage.
CONCLUSIONS:
In this way, PhnZ adopts a mechanism quite different from the related diiron oxygenase MIOX, with His62 residue playing an important role. This unusual “inverse” heterolytic O-O cleavage mode, apart from the well-known homolytic and “normal” heterolytic ones, constitutes a third iron-mediated O-O activation scenario in nature, which is expected to have its broad occurrence in oxidative transformation involving heteroatoms of sulfur and phosphorus.

Product Name	(2-Amino-1-hydroxyethyl)phosphonic acid
Price:
CAS No.:	115511-00-7
Catalog No.:	CFN00043
Molecular Formula:	C₂H₈NO₄P
Molecular Weight:	141.06 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Cryst.
Source:	From Acanthamoeba castellanii
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	7.0892 mL	35.4459 mL	70.8918 mL	141.7836 mL	177.2295 mL
5 mM	1.4178 mL	7.0892 mL	14.1784 mL	28.3567 mL	35.4459 mL
10 mM	0.7089 mL	3.5446 mL	7.0892 mL	14.1784 mL	17.723 mL
50 mM	0.1418 mL	0.7089 mL	1.4178 mL	2.8357 mL	3.5446 mL
100 mM	0.0709 mL	0.3545 mL	0.7089 mL	1.4178 mL	1.7723 mL

CFN00011	(2-Acetoxyethyl)trimethylammonium	51-84-3	146.21	C₇H₁₆NO₂+
CFN00012	Actinine	407-64-7	145.2	C₇H₁₅NO₂
CFN00019	Hypotaurine	300-84-5	109.15	C₂H₇NO₂S
CFN00020	Taurine	107-35-7	125.15	C₂H₇NO₃S
CFN00026	2-Aminoethanol	141-43-5	61.08	C₂H₇NO
CFN00027	O-Acetylethanolamine	1854-30-4	103.12	C₄H₉NO₂
CFN00028	2-Methylaminoethanol	109-83-1	75.11	C₃H₉NO
CFN00043	(2-Amino-1-hydroxyethyl)phosphonic acid	115511-00-7	141.06	C₂H₈NO₄P