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More articles cited ChemFaces products.
PhytomedicineFeb. 11. 2016Advance Publication2015 Aug 18Food Research InternationalJan. 2016Food Res Int. 2017 Jun;Phytomedicine.2018 Jan 1;
ARPN Journal of Eng.& Applied Sci.4, Feb. 2016 Front Pharmacol. 2017 Sep 29;Industrial Crops and Products.2015, P 185-191Horticultural Science2016J Chromatogr B Analyt Tec. Bio. Life Sci. 2018 Feb 17;
Phytomedicine1 March 2018;Evid Based Complement Alternat Med. 2016 May 24; Journal of Life Science2017.2;BMC Complement Altern Med.2014 Sep 23;14:352.
Our products had been exported to the following research institutions and universities, And still growing.
Ateneo de Manila University (Philippines)Johannes Gutenberg University Ma... (Germany)Universite Libre de Bruxelles (Belgium)Periyar University (India)
MTT Agrifood Research Finland (Finland)Fraunhofer-Institut für Molekul... (Germany)Sri Sai Aditya Institute of Phar... (India)University of Fribourg (Switzerland)
Sant Gadge Baba Amravati Univers... (India)University of Toronto (Canada)National Cancer Institute (USA)
||Anthraquinone-2-carboxylic acid is a novel electron shuttling mediator, shows potent anti-inflammatory and antinociceptive activities in vivo, thus contributing to the immune regulatory role of fruits and herbs.|
||AP-1 | NF-kB | Src | Syk | p38MAPK|
|Mediators Inflamm. 2016; 2016: 1903849. |
|Anti-Inflammatory and Antinociceptive Activities of Anthraquinone-2-Carboxylic Acid[Pubmed: 27057092]|
|Anthraquinone compounds are one of the abundant polyphenols found in fruits, vegetables, and herbs. However, the in vivo anti-inflammatory activity and molecular mechanisms of anthraquinones have not been fully elucidated. |
METHODS AND RESULTS:
We investigated the activity of anthraquinones using acute inflammatory and nociceptive experimental conditions. Anthraquinone-2-carboxylic acid (2-Anthraquinonecarboxylic acid,9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid, AQCA), one of the major anthraquinones identified from Brazilian taheebo, ameliorated various inflammatory and algesic symptoms in EtOH/HCl- and acetylsalicylic acid- (ASA-) induced gastritis, arachidonic acid-induced edema, and acetic acid-induced abdominal writhing without displaying toxic profiles in body and organ weight, gastric irritation, or serum parameters. In addition, AQCA suppressed the expression of inflammatory genes such as cyclooxygenase- (COX-) 2 in stomach tissues and lipopolysaccharide- (LPS-) treated RAW264.7 cells. According to reporter gene assay and immunoblotting analyses, AQCA inhibited activation of the nuclear factor- (NF-) κB and activator protein- (AP-) 1 pathways by suppression of upstream signaling involving interleukin-1 receptor-associated kinase 4 (IRAK1), p38, Src, and spleen tyrosine kinase (Syk).
Our data strongly suggest that anthraquinones such as AQCA act as potent anti-inflammatory and antinociceptive components in vivo, thus contributing to the immune regulatory role of fruits and herbs.
2-Anthraquinonecarboxylic acid Description
||The roots of Rubia cordifolia L.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi: 10.1016/j.phymed.2017.12.030.PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Journal of Materials Chemistry.2011 Aug;21(39):15383-15390. |
|Photo-induced self-cleaning functions on 2-anthraquinone carboxylic acid treated cotton fabrics.[Reference: WebLink]|
METHODS AND RESULTS:
Self-cleaning cotton fabrics were obtained via chemically incorporating photosensitive 2-Anthraquinonecarboxylic acid (2-AQC) onto the fibers through a mild and efficient esterification reaction. The 2-Anthraquinonecarboxylic acid structures on the treated cotton were confirmed by FTIR characterization. SEM images revealed that the cotton fiber surface became rougher than that of the original cotton fiber after the treatment. TGA analysis confirmed that thermal stability of the treated fibers was almost unchanged. The 2-Anthraquinonecarboxylic acid treated cotton fabrics demonstrated excellent photo-induced self-cleaning properties, including decomposition of 90% aldicarb in 3 hours of UVA exposure and inactivation of over 99% of both E. coli and S. aureus in 1 hour of the light exposure.
The self-cleaning functions are a result of formation of reactive oxygen species on the light irradiated and 2-Anthraquinonecarboxylic acid treated cotton. The amount of H2O2 formed on the fabrics was determined by a titration method.