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British Jou. Med. & Med. Research2014 Jan 1ScientificWorldJournal. 2014 Feb 9.Analytical sci. & Tech2016Srinagarind Medical JournalNo 1 (2017) Clin Exp Pharmacol Physiol.2015 Aug 1
J Agric Food Chem.2016 Sep 7The Japan Society for Analy. Chem.2017 Nov. 8;Badan Litbangkes Kemenkes RINo 4 (2016)BMC Complement Altern Med.2017 Aug 3;J Biochem Mol Toxicol. 2017 Jun 7
Front Plant Sci. 2017 May 8;Molecules. 2017 Feb 21;Am J Chin Med.2016;44(8)Sci Rep. 2017 Jan 9;
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||20(R)-Ginsenoside Rh2, a minor stereoisomer of ginsenoside Rh2, possesses matrix metalloproteinase inhibitory. 20(R)-Ginsenoside Rh2 has anticancer, anti- proliferation, anti-inflammatory and antioxidative activities, it also shows selective osteoclastgenesis inhibitory activity. 20(R)-Ginsenoside Rh2 reduce apoptotic rate significantly, enhance the activity of caspase-3 and induces apoptosis in human lung adenocarcinoma A549 cells.|
||NO | PGE | MMP(e.g.TIMP) | ROS | TNF-α | Caspase|
|Zhongguo Zhong Yao Za Zhi. 2011 Jun;36(12):1670-4. |
|Effects of 20 (S) -ginsenoside Rh2 and 20 (R) -ginsenoside Rh2 on proliferation and apoptosis of human lung adenocarcinoma A549 cells.[Pubmed: 22007558]|
| To evaluate and explore the effects of 20(S)-ginsenoside Rh2 and 20(R)-Ginsenoside Rh2 on the cytotoxicity, proliferation and the apoptosis of human lung adenocarcinoma A549 cells, and to illustrate the structure-activity relationship and possible mechanisms of anti-tumor active ingredients of ginseng. |
METHODS AND RESULTS:
A549 cells were treated with different concentration gradient of 20(R)-Ginsenoside Rh2 (S and R structure) and incubated for different time.MTT test indicated that 20(R)-Ginsenoside Rh2 had a strong cytotoxicity activity to A549 cells. Ginsenoside Rh2 could obviously inhibit the cell proliferation in human lung adenocarcinoma cell line A549 at the effective doses of 25 mg x L(-1) treated with 48 h.
20(R)-Ginsenoside Rh2 and 20(S)-ginsenoside Rh2 had a significant inhibitory effect on the proliferation. Compared with 20(S)-ginsenoside Rh2, 20 (S)-ginsenoside Rh2 has been shown to have significant anticancer effects and to be capable of blocking cell proliferation and causing G1 phase arrest in human lung adenocarcinoma A549 cells. 20(R)-Ginsenoside Rh2 and 20(S)-ginsenoside Rh2 have been shown to have anticancer effects and to be capable of increasing inchoate apoptotic rate, reducing apoptotic rate significantly, enhancing the activity of Caspase-3 and inducing apoptosis in human lung adenocarcinoma A549 cells.
|Bioorg Med Chem Lett. 2009 Jun 15;19(12):3320-3. |
|20(R)-ginsenoside Rh2, not 20(S), is a selective osteoclastgenesis inhibitor without any cytotoxicity.[Pubmed: 19428246]|
|Increased osteoclastic bone resorption plays a central role in the pathogenesis of many bone diseases, and osteoclast inhibitors are the most widely used treatments for these diseases. Ginsenosides, the main component of ginseng, have been known for their medicinal effects such as anti-inflammatory and anti-proliferative activities. |
METHODS AND RESULTS:
In this study, we investigated the inhibitory effects of ginsenosides (20(R)-Ginsenoside Rh2 and ginsenoside 20(S)-Rh2) on osteoclastgenesis using RAW264 cells in vitro. Only 20(R)-Ginsenoside Rh2 showed selective osteoclastgenesis inhibitory activity without any cytotoxicity up to 100 microM.
These results implied that the stereochemistry of the hydroxyl group at C-20 may play an important role in selective osteoclastgenesis inhibitory activity.
20(R)-Ginsenoside Rh2 Description
||The roots of Panax ginseng C. A. Mey.
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi: 10.1016/j.phymed.2017.12.030.PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|J Pharm Pharmacol. 2013 Feb;65(2):310-6. |
|Anti-inflammatory, antioxidative and matrix metalloproteinase inhibitory properties of 20(R)-ginsenoside Rh2 in cultured macrophages and keratinocytes.[Pubmed: 23278699]|
|This work aimed to assess the matrix metalloproteinase inhibitory and related pharmacological actions of 20(R)-Ginsenoside Rh2 (20(R)-Rh2) in cultured macrophages and keratinocytes. |
METHODS AND RESULTS:
In-vitro anti-inflammatory activity of 20(R)-Ginsenoside Rh2 was evaluated by analysing nitric oxide (NO) and prostaglandin E2 (PGE2) contents in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. Its antioxidant activity was determined by measuring the level of reactive oxygen species (ROS) in the macrophage and keratinocyte cells. Matrix metalloproteinase-9 (MMP-9) and -2 (MMP-2) activity in the culture medium was detected using zymography. 20(R)-Ginsenoside Rh2 was able to suppress NO, PGE2, ROS and pro-matrix metalloproteinase-9 (pro-MMP-9) levels that were enhanced in the LPS-stimulated murine RAW264.7 macrophage cells. 20(R)-Rh2 also exhibited inhibitory effects on the level of ROS and the activity of MMP-9 and -2 in human HaCat keratinocyte cells without stimulant exposure. 20(R)-Ginsenoside Rh2 could suppress the gelatinolytic activity of MMP-9 enhanced by tumour necrosis factor-α in the keratinocytes.
20(R)-Ginsenoside Rh2, a minor stereoisomer of ginsenoside Rh2, possesses matrix metalloproteinase inhibitory, anti-inflammatory and antioxidative activity.