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    3-O-Acetyl-beta-boswellic acid
    Information
    CAS No. 5968-70-7 Price
    Catalog No.CFN90530Purity>=98%
    Molecular Weight498.74Type of CompoundTriterpenoids
    FormulaC32H50O4Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: 3-O-Acetyl-beta-boswellic acid has antitumor activity, it inhibits synthesis of DNA, RNA and protein in human leukemia HL-60 cells in a dose dependent manner with IC50 values ranging from 0.6 to 7.1 microM.
    Targets: DNA/RNA Synthesis
    In vitro:
    Planta Med. 1998 May;64(4):328-31.
    Inhibitory activity of boswellic acids from Boswellia serrata against human leukemia HL-60 cells in culture.[Pubmed: 9619114]
    Four major triterpene acids including beta-boswellic acid (1), 3-O-Acetyl-beta-boswellic acid (2), 11-keto-beta-boswellic acid (3), and 3-O-acetyl-11-keto-beta-boswellic acid (4) were isolated from the gum resin of Boswellia serrata and examined for their in vitro antitumor activity.
    METHODS AND RESULTS:
    They inhibited the synthesis of DNA, RNA and protein in human leukemia HL-60 cells in a dose dependent manner with IC50 values ranging from 0.6 to 7.1 microM. Among them, compound 4 induced the most pronounced inhibitory effects on DNA, RNA and protein synthesis with IC50 values of 0.6, 0.5, and 4.1 microM, respectively.
    CONCLUSIONS:
    The effect of 4 on DNA synthesis was found to be irreversible. Compound 4 significantly inhibited the cellular growth of HL-60 cells, but did not affect cell viability.
    3-O-Acetyl-beta-boswellic acid Description
    Source: The herbs of Boswellia carterii Birdw.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0051 mL 10.0253 mL 20.0505 mL 40.1011 mL 50.1263 mL
    5 mM 0.401 mL 2.0051 mL 4.0101 mL 8.0202 mL 10.0253 mL
    10 mM 0.2005 mL 1.0025 mL 2.0051 mL 4.0101 mL 5.0126 mL
    50 mM 0.0401 mL 0.2005 mL 0.401 mL 0.802 mL 1.0025 mL
    100 mM 0.0201 mL 0.1003 mL 0.2005 mL 0.401 mL 0.5013 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Phytochem Anal. 2001 Nov-Dec;12(6):374-6.
    High-performance thin layer chromatographic analysis of anti-inflammatory triterpenoids from Boswellia serrata Roxb.[Pubmed: 11793815]

    METHODS AND RESULTS:
    A rapid and simple high-performance thin layer chromatographic (HPTLC) method was developed for the simultaneous quantitative estimation of the biologically active triterpenoids beta-boswellic acid, 3-O-Acetyl-beta-boswellic acid, 11-keto-beta-boswellic acid and 3-O-acetyl-11-keto-beta-boswellic acid from the gum resin of Boswellia serrata. The assay combines the isolation and separation of boswellic acid derivatives on silica gel 60F254-HPTLC plates with spot visualisation and scanning at 250 nm.
    CONCLUSIONS:
    Methanol was found to be the most appropriate solvent for the exhaustive extraction of boswellic acid derivatives.