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    4,4'-Methylenediphenol
    Information
    CAS No. 620-92-8 Price $30 / 20mg
    Catalog No.CFN90549Purity>=98%
    Molecular Weight200.23Type of CompoundPhenols
    FormulaC13H12O2Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: 4,4'-Methylenediphenol is a high purity product from Gastrodia rhizome.
    In vitro:
    Biomed Chromatogr. 2016 Jun;30(6):976-82.
    Preparative purification of plasmin activity stimulating phenolic derivatives from Gastrodia elata using centrifugal partition chromatography.[Pubmed: 26517716 ]
    Gastrodia rhizome, a dried and steamed tuber of Gastrodia elata Blume (Orchidaceae), has been traditionally used in Korea, China and Japan for the treatment of neurological and nervous disorders such as headaches, dizziness, vertigo and convulsive illnesses. The ethyl acetate and water extracts of G. elata stimulated plasmin activity.
    METHODS AND RESULTS:
    The active ethyl acetate fraction was subjected to centrifugal partition chromatography (CPC) with a two-phase solvent system, composed of n-hexane-ethyl acetate-methanol-water (3:7:4:6, v/v) followed by semi-preparative HPLC purification to separate active compounds and the water fraction was purified by Diaion HP-20 resin and semi-preparative HPLC. In ethyl acetate extract, 4-hydroxybenzyl alcohol (1), 4-hydroxybenzoic acid (2), 4-hydroxybenzaldehyde (3), 4-ethoxymethylphenol (4), 4,4'-oxybis(methylene)diphenol (5) and 4,4'-Methylenediphenol (6) were obtained with high purities. Parishin (7) and parishin B (8) were isolated from water extract.
    CONCLUSIONS:
    Among isolated compounds, 4-hydroxybenzyl alcohol (1), 4-hydroxybenzaldehyde (3) and 4-ethoxymethylphenol (4) significantly stimulated plasmin activity.
    4,4'-Methylenediphenol Description
    Source: The tubers of Gastrodia elata Blume.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.9943 mL 24.9713 mL 49.9426 mL 99.8851 mL 124.8564 mL
    5 mM 0.9989 mL 4.9943 mL 9.9885 mL 19.977 mL 24.9713 mL
    10 mM 0.4994 mL 2.4971 mL 4.9943 mL 9.9885 mL 12.4856 mL
    50 mM 0.0999 mL 0.4994 mL 0.9989 mL 1.9977 mL 2.4971 mL
    100 mM 0.0499 mL 0.2497 mL 0.4994 mL 0.9989 mL 1.2486 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.