4-Methoxycoumarine | CAS:20280-81-3 | Manufacturer ChemFaces

4-Methoxycoumarine

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Description:

4-Methoxycoumarin has antitumour effects.

In vitro:

Melanoma Research, 1999, 9(3):243-248.

Cytostatic activity of coumarin metabolites and derivatives in the B16-F10 murine melanoma cell line.[Reference: WebLink]

Coumarin has antitumour effects in vivo and cytostatic effects in vitro. Its half-life in humans is short (1-1.5 h) and the monohydroxylated biotransformation products have significantly longer half-lives. One or several of these products may thus be responsible for the antitumoral effects.
METHODS AND RESULTS:
We have assayed the in vitro cytostatic activity of five monohydroxylated coumarins (3-, 4-, 6-, 7- and 8-monohydroxycoumarin), their acetates and methyl-ethers. Murine melanoma cells (cell line B16-F10) and murine fibroblasts (B82) were exposed to the test compounds at concentrations between 10 and 160 microg/ml. The cytostatic effects were estimated by reduction of the tetrazolium dye MTT. In the melanoma cells, some of the compounds inhibited growth after exposure for 1 day. In contrast, coumarin inhibited growth to a smaller extent, and only after exposure for 3 days. The most active compounds (3-acetoxycoumarin, 4-methoxycoumarin(4-Methoxycoumarine) and 6-hydroxycoumarin), as well as coumarin, were also assayed in murine fibroblasts.
CONCLUSIONS:
The cytostatic effects of 4-methoxycoumarin(4-Methoxycoumarine) and 6-hydroxycoumarin were less pronounced in fibroblasts than in melanoma cells. Our observations suggest that these compounds may have a greater therapeutic margin.

4-Methoxycoumarine Description

Source:	The herbs of Guazuma ulmifolia
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	4-Methoxycoumarine
Price:	$158 / 20mg
CAS No.:	20280-81-3
Catalog No.:	CFN94403
Molecular Formula:	C₁₀H₈O₃
Molecular Weight:	176.17 g/mol
Purity:	>=98%
Type of Compound:	Coumarins
Physical Desc.:	Powder
Source:	The herbs of Guazuma ulmifolia
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Coumarins Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.6763 mL	28.3817 mL	56.7634 mL	113.5267 mL	141.9084 mL
5 mM	1.1353 mL	5.6763 mL	11.3527 mL	22.7053 mL	28.3817 mL
10 mM	0.5676 mL	2.8382 mL	5.6763 mL	11.3527 mL	14.1908 mL
50 mM	0.1135 mL	0.5676 mL	1.1353 mL	2.2705 mL	2.8382 mL
100 mM	0.0568 mL	0.2838 mL	0.5676 mL	1.1353 mL	1.4191 mL

CFN99621	Marmin	14957-38-1	332.4	C₁₉H₂₄O₅
CFN98408	Marmin acetonide	320624-68-8	372.5	C₂₂H₂₈O₅
CFN97584	7'-O-Ethylmarmin	N/A	360.5	C₂₁H₂₈O₅
CFN98274	Excavatin M	250293-31-3	360.4	C₁₉H₂₀O₇
CFN89254	Diversoside	55062-36-7	494.53	C₂₅H₃₄O₁₀
CFN99552	Coumarin	91-64-5	146.15	C₉H₆O₂
CFN96597	6-Methylcoumarin	92-48-8	160.17	C₁₀H₈O₂
CFN91113	7-Methylcoumarin	2445-83-2	160.17	C₁₀H₈O₂
CFN97503	Umbelliferone	93-35-6	162.1	C₉H₆O₃
CFN90566	7-Methoxycoumarin	531-59-9	176.2	C₁₀H₈O₃