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5'-Demethylaquillochin
5'-Demethylaquillochin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 5'-Demethylaquillochin
Price:
CAS No.: 305364-91-4
Catalog No.: CFN98388
Molecular Formula: C20H18O9
Molecular Weight: 402.4 g/mol
Purity: >=98%
Type of Compound: Coumarins
Physical Desc.: Powder
Source: The herbs of Mallotus apelta
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 5'-Demethylaquillochin and its isomer from the dichloromethane extract of E. cavaleriei have potential as chemopreventive agents through induction of detoxification enzymes. 5'-Demethylaquillochin exhibits the most potential chemopreventive ability.
Targets: NADPH-oxidase | SOD
In vitro:
J Chromatogr A. 2009 Jun 12;1216(24):4859-67.
Characterization of chemopreventive agents from the dichloromethane extract of Eurycorymbus cavaleriei by liquid chromatography-ion trap mass spectrometry.[Pubmed: 19439309]

METHODS AND RESULTS:
The relative ability to induce the detoxification enzyme, NAD(P)H:quinone oxidoreductase 1 (NQO1) of nine coumarin compounds was tested which also showed 5'-Demethylaquillochin exhibited the most potential chemopreventive ability.
CONCLUSIONS:
These observations suggest that 5'-Demethylaquillochin and its isomer from the dichloromethane extract of E. cavaleriei have potential as chemopreventive agents through induction of detoxification enzymes.
Chem Biodivers. 2008 Apr;5(4):591-7.
New hepatoprotective coumarinolignoids from Mallotus apelta.[Pubmed: 18421750]

METHODS AND RESULTS:
Three new coumarinolignoids, malloapelins A-C (1-3, resp.), together with three known coumarinolignoids, cleomiscosin A (4), cleomiscosin B (5), and 5'-Demethylaquillochin (6), were isolated from the roots of Mallotus apelta MUELL.-ARG. Compounds 1-6 are three pairs of regioisomeric coumarinolignoids. Their structures were elucidated on the basis of spectral evidence.
CONCLUSIONS:
Compounds 3 showed promising hepatoprotective activity against D-galactosamine-induced toxicity in WB-F344 rat hepatic epithelial stem-like cells.
5'-Demethylaquillochin Description
Source: The herbs of Mallotus apelta
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
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Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

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IF=13.903(2019)

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Nature Plants. 2016 Dec 22;3: 16206.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.4851 mL 12.4254 mL 24.8509 mL 49.7018 mL 62.1272 mL
5 mM 0.497 mL 2.4851 mL 4.9702 mL 9.9404 mL 12.4254 mL
10 mM 0.2485 mL 1.2425 mL 2.4851 mL 4.9702 mL 6.2127 mL
50 mM 0.0497 mL 0.2485 mL 0.497 mL 0.994 mL 1.2425 mL
100 mM 0.0249 mL 0.1243 mL 0.2485 mL 0.497 mL 0.6213 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Nat Med. 2011 Jan;65(1):191-3.
Aromatic compounds and their antioxidant activity of Acer saccharum.[Pubmed: 20686865]

METHODS AND RESULTS:
A new lignan glycoside, 5-(3″,4″-dimethoxy-phenyl)-3-hydroxy-3-(4'-hydroxy-3'-methoxybenzyl)-4-hydroxymethyl-dihydrofuran-2-one 4'-O-α-L: -rhamnopyranoside (1), with seven known compounds, compound 2, koaburside, icariside E(4), cleomiscosin C, cleomiscosin D, scopoletin, and 5'-Demethylaquillochin, were isolated from the EtOH extract of the wood of Acer saccharum (Aceraceae). Their structures were determined by 1D and 2D nuclear magnetic resonance (NMR) and mass spectroscopy analysis.
CONCLUSIONS:
All of the isolated compounds, 1-8, were tested for their antioxidant activity in superoxide dismutase (SOD)-like assay.
Fitoterapia. 2000 Jun;71(3):341-2.
Coumarinolignoids of Mallotus apelta.[Pubmed: 10844178]

METHODS AND RESULTS:
Three coumarino-lignoids, aquillochin (1), cleomiscosin A and 5'-Demethylaquillochin have been isolated from Mallotus apelta. The structure of the new compound 3 was determined by spectroscopic techniques.
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