|Description:||1. 6,7,8-Trimethoxycoumarin shows high anti-HRV-2 effect , with IC (50) value of 11.98 muM .|
2. 6,7,8-Trimethoxycoumarin and 5,6,7-trimethoxycoumarin can improve gastroprotective effects.
|Targets:||P450 (e.g. CYP17) | AChR | Antifection|
|Source:||The herbs of Viola yedonensis Makino.|
|Solvent:||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||4.2337 mL||21.1685 mL||42.337 mL||84.674 mL||105.8425 mL|
|5 mM||0.8467 mL||4.2337 mL||8.4674 mL||16.9348 mL||21.1685 mL|
|10 mM||0.4234 mL||2.1169 mL||4.2337 mL||8.4674 mL||10.5843 mL|
|50 mM||0.0847 mL||0.4234 mL||0.8467 mL||1.6935 mL||2.1169 mL|
|100 mM||0.0423 mL||0.2117 mL||0.4234 mL||0.8467 mL||1.0584 mL|
Nutrients. 2015 Mar 13;7(3):1945-64.
|Gastroprotective efficacy and safety evaluation of scoparone derivatives on experimentally induced gastric lesions in rodents.[Pubmed: 25781220]|
|Among these compounds, 5,6,7-trimethoxycoumarin and 6,7,8-Trimethoxycoumarin were found to have gastroprotective activity greater than the standard drug rebamipide; 6-methoxy-7,8-methylenedioxycoumarin, 6-methoxy-7,8-(1-methoxy)-methylenedioxycoumarin, 6,7-methylenedioxycoumarin, and 6,7-(1-methoxy)-methylenedioxycoumarin were found to be equipotent or less potent that of rebamipide. Pharmacological studies suggest that the presence of a methoxy group at position C-5 or C-8 of the scoparone's phenyl ring significantly improves gastroprotective activity, whereas the presence of a dioxolane ring at C-6, C-7, or C-8 was found to have decreased activity. In order to assess toxicological safety, two of the potent gastroprotective scoparone derivatives-5,6,7-trimethoxycoumarin and 6,7,8-Trimethoxycoumarin-were examined for their acute toxicity in mice as well as their effect on cytochrome P450 (CYP) enzyme activity. These two compounds showed low acute oral toxicity in adult male and female mice, and caused minimal changes to CYP3A4 and CYP2C9 enzyme activity. These results indicate that compared to other scoparone derivatives, 5,6,7-trimethoxycoumarin and 6,7,8-Trimethoxycoumarin can improve gastroprotective effects, and they have low toxicity and minimal effects on drug-metabolizing enzymes.|
Planta Med. 2009 Feb;75(3):195-204.
|In silico target fishing for rationalized ligand discovery exemplified on constituents of Ruta graveolens.[Pubmed: 19096995]|
|For AChE the highest scoring virtual hit, arborinine, showed the best inhibitory IN VITRO activity on AChE (IC (50) 34.7 muM). Determination of the anti-HRV-2 effect revealed 6,7,8-Trimethoxycoumarin and arborinine to be the most active antiviral constituents with IC (50) values of 11.98 muM and 3.19 muM, respectively.|
J Ethnopharmacol. 1999 Dec 15;68(1-3):283-8.
|Antiviral flavonoid from Pterocaulon sphacelatum, an Australian Aboriginal medicine.[Pubmed: 10624889]|
|This compound is a 4'-hydroxy-3-methoxyflavone, one of a group of compounds known to be potent and specific inhibitors of picornaviral replication. These compounds inhibit the replication of rhinoviruses, the most frequent causative agent of the common cold. The coumarin 6,7,8-Trimethoxycoumarin was also isolated from the ethanolic extract.|