6-Hydroxykaempferol 3,6-diglucoside | CAS:142674-16-6

6-Hydroxykaempferol 3,6-diglucoside

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Description:

6-Hydroxykaempferol 3,6-di-O-glucoside and 6-hydroxykaempferol 3,6,7-tri-O-glucoside can inhibit platelet aggregation induced by collagen, they also show weak inhibitory effects on the adenosine 5'-diphosphate (ADP)- induced platelet aggregation.

In vitro:

Natural Med., 2005, 59(5):241-4.

Antiplatelet Aggregatory Effects of the Constituents Isolated from the Flower of Cartham.ua tinctorius[Reference: WebLink]

METHODS AND RESULTS:
Four constituents, 6-hydroxykaempferol 3,6,7-tri-O-glucoside (1), 6-hydroxykaempferol 3-O-rutinoside-6-O-glucoside (2), 6-hydroxykaempferol 3,6-di-O-glucoside (6-Hydroxykaempferol 3,6-diglucoside,3), and syringin (4) were isolated from the flower of Carthamus tinctorius L. and were examined for the inhibitory effects on platelet aggregation. The platelet aggregation was monitored by a platelet aggregometer employing a laser-scattering method. The compounds were identified on the basis of NMR spectral data.
CONCLUSIONS:
Compound 1, 3 and 4 inhibited platelet aggregation induced by collagen. Compound 4 also showed an antiplatelet aggregatory effect when the platelet aggregation was induced by adenosine 5'-diphosphate (ADP). However, 2 showed no inhibitory effect on platelet aggregation induced by collagen or ADP. Furthermore, 1 and 3 showed weak inhibitory effects on the ADP-induced platelet aggregation.

6-Hydroxykaempferol 3,6-diglucoside Description

Source:	The herbs of Chrysactinia tinctorius
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Biomed Chromatogr. 2006 Aug;20(8):821-6.

An HPLC/MS method for identifying major constituents in the hypocholesterolemic extracts of Chinese medicine formula 'Xue-Fu-Zhu-Yu decoction'.[Pubmed: 16345012]

METHODS AND RESULTS:
In this paper, HPLC-ESI-MS technique was used to analyze the hypocholesterolemic extracts of 'Xue-Fu-Zhu-Yu decoction', a traditional Chinese medicine consisting of six crude drugs (i.e. Paeonia lactiflora, Ligusticum chuanxiong, Citrus aurantium, Carthamus tinctorius, Prunus persica and Bupleurum falcatum). A total of 17 compounds were identified and their plant derivations were also distinguished. Nine compounds among them were unambiguously determined as oxypaeoniflorin, amygdalin, albiflorin, paeoniflorin, ferulic acid, naringin, hesperidin, senkyunolide I and neohesperidin by comparing the retention times (tR), UV spectra and m/z values with those of the reference compounds.
CONCLUSIONS:
The other eight compounds were tentatively identified as prunasin, 6-Hydroxykaempferol 3,6-diglucoside, 6-hydroxykaempferol 3-rutinoside-6-glucoside, galloylpaeoniflorin, 6-hydroxy-kaempferol 3-glucoside, anhydrosafflor yellow B, narirutin and kaempferol 3-rutinoside by MS2 spectra and the comparison of their UV spectra and MS spectra with literature data.

Product Name	6-Hydroxykaempferol 3,6-diglucoside
Price:	$388 / 5mg
CAS No.:	142674-16-6
Catalog No.:	CFN92371
Molecular Formula:	C₂₇H₃₀O₁₇
Molecular Weight:	626.5 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Yellow powder
Source:	The herbs of Chrysactinia tinctorius
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-platelet aggregation Compound Library Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.5962 mL	7.9808 mL	15.9617 mL	31.9234 mL	39.9042 mL
5 mM	0.3192 mL	1.5962 mL	3.1923 mL	6.3847 mL	7.9808 mL
10 mM	0.1596 mL	0.7981 mL	1.5962 mL	3.1923 mL	3.9904 mL
50 mM	0.0319 mL	0.1596 mL	0.3192 mL	0.6385 mL	0.7981 mL
100 mM	0.016 mL	0.0798 mL	0.1596 mL	0.3192 mL	0.399 mL

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