Science | Nature | Cell | View More
Natural Products
6-beta-Hydroxyhyoscyamine
6-beta-Hydroxyhyoscyamine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 6-beta-Hydroxyhyoscyamine
Price:
CAS No.: 55869-99-3
Catalog No.: CFN00198
Molecular Formula: C17H23NO4
Molecular Weight: 305.37 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The roots of Anisodus tanguticus
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of Bonn (Germany)
  • Amity University (India)
  • Lodz University of Technology (Poland)
  • Almansora University (Egypt)
  • Cornell University (USA)
  • Georgia Institute of Technology (USA)
  • Massachusetts General Hospital (USA)
  • Sanford Burnham Medical Researc... (USA)
  • Molecular Biology Institute of ... (Spain)
  • University of Mysore (India)
  • Aveiro University (Portugal)
  • More...
Package
Featured Products
6''-O-Malonylgenistin

Catalog No: CFN90631
CAS No: 51011-05-3
Price: $348/5mg
Tricin

Catalog No: CFN98841
CAS No: 520-32-1
Price: $258/10mg
Lucidenic acid A

Catalog No: CFN90574
CAS No: 95311-94-7
Price: $318/20mg
Schizandrin C

Catalog No: CFN99708
CAS No: 61301-33-5
Price: $128/20mg
Vicenin -3

Catalog No: CFN92032
CAS No: 59914-91-9
Price: $198/20mg
Sophoricoside

Catalog No: CFN90148
CAS No: 152-95-4
Price: $40/20mg
Dihydroevocarpine

Catalog No: CFN92786
CAS No: 15266-35-0
Price: $268/10mg
Timosaponin BII

Catalog No: CFN98150
CAS No: 136656-07-0
Price: $50/20mg
Zeaxanthin

Catalog No: CFN90234
CAS No: 144-68-3
Price: $ / mg
Biochanin A

Catalog No: CFN99734
CAS No: 491-80-5
Price: $40/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: 6-beta-Hydroxyhyoscyamine and 7 beta-hydroxyhyoscyamine exhibit similar affinities at the muscarinic receptor as scopolamine and atropine.
Targets: AChR
In vitro:
Pharmazie. 1995 Jul;50(7):493-5.
Binding of tropane alkaloids to nicotinic and muscarinic acetylcholine receptors.[Pubmed: 7675895]

METHODS AND RESULTS:
Fourteen tropane and related alkaloids were analyzed for their affinity for nicotinic and/or muscarinic acetylcholine receptors. The biogenetic intermediates littorine, 6-beta-Hydroxyhyoscyamine, 7 beta-hydroxyhyoscyamine exhibit similar affinities at the muscarinic receptor as scopolamine and atropine.
CONCLUSIONS:
The quarternary derivatives N-methylatropine and N-methylscopolamine show the highest binding with IC50 values of less than 100 pM and 300 pM, respectively. The tropane alkaloids (including cocaine) also bind to the nicotinic acetylcholine receptor, albeit with much lower affinities.
6-beta-Hydroxyhyoscyamine Description
Source: The roots of Anisodus tanguticus
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
12-Acetoxy ganoderic acid D

Catalog No: CFN95535
CAS No: N/A
Price: $318/5mg
Isonardosinone

Catalog No: CFN95180
CAS No: 27062-01-7
Price: $318/10mg
Isovalerylshikonin

Catalog No: CFN95222
CAS No: 52387-14-1
Price: $318/10mg
Bidenoside C

Catalog No: CFN95266
CAS No: 700877-55-0
Price: $318/5mg
4-Methoxybenzoylacetic acid

Catalog No: CFN95446
CAS No: 13422-77-0
Price: $318/5mg
Yuankanin

Catalog No: CFN95128
CAS No: 77099-20-8
Price: $318/5mg
(1E)-3-methoxy-8,12-epoxygermacra-...

Catalog No: CFN95219
CAS No: 1393342-06-7
Price: $413/5mg
Euphorbia factor L25

Catalog No: CFN95339
CAS No: 303174-98-3
Price: $368/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2747 mL 16.3736 mL 32.7472 mL 65.4943 mL 81.8679 mL
5 mM 0.6549 mL 3.2747 mL 6.5494 mL 13.0989 mL 16.3736 mL
10 mM 0.3275 mL 1.6374 mL 3.2747 mL 6.5494 mL 8.1868 mL
50 mM 0.0655 mL 0.3275 mL 0.6549 mL 1.3099 mL 1.6374 mL
100 mM 0.0327 mL 0.1637 mL 0.3275 mL 0.6549 mL 0.8187 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Planta Med. 2005 Mar;71(3):249-53.
Molecular cloning, expression and characterization of hyoscyamine 6beta-hydroxylase from hairy roots of Anisodus tanguticus.[Pubmed: 15770546]

METHODS AND RESULTS:
Anisodus tanguticus, one of the indigenous Chinese ethnological medicinal plants of the Solanaceae, produces anticholinergic alkaloids such as hyoscyamine, 6 beta-hydroxyhyoscyamine and scopolamine. Hyoscyamine 6 beta-hydroxylase (H6H), a key enzyme in the biosynthetic pathway of scopolamine, catalyzes the hydroxylation of hyoscyamine and epoxide formation from 6-beta-Hydroxyhyoscyamine to generate scopolamine. A full-length cDNA of H6H has been isolated from A. tanguticus hairy roots. Nucleotide sequence analysis of the cloned cDNA revealed an open reading frame of 1035 bp encoding 344 amino acids with high homology to other known H6Hs. The equivalent amino acid sequence shows a typical motif of 2-oxoglutarate-dependent dioxygenase. The A. tanguticus H6H was expressed in Escherichia coli and purified for enzyme function analysis.
CONCLUSIONS:
This study characterized the recombinant AtH6H and showed it could generate scopolamine from hyoscyamine.
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku. 2002;(120):85-8.
Tropane alkaloids in auxin-independent root cultures of Physochlaina physaloides.[Pubmed: 12638187]

METHODS AND RESULTS:
Adventitious and hairy root cultures of Physochlaina physaloides were established. These roots grew well and produced high amounts of tropane alkaloids (particularly hyoscyamine and 6-beta-Hydroxyhyoscyamine) in auxin-free culture medium. The effects of basal media and temperature on the growth and alkaloid production of these roots were investigated.
CONCLUSIONS:
Both root cultures produced highest amount of tropane alkaloids in B5 medium though the optimum temperature for hairy roots were lower than that for adventitious roots.
6''-O-Malonylgenistin

Catalog No: CFN90631
CAS No: 51011-05-3
Price: $348/5mg
Tricin

Catalog No: CFN98841
CAS No: 520-32-1
Price: $258/10mg
Lucidenic acid A

Catalog No: CFN90574
CAS No: 95311-94-7
Price: $318/20mg
Schizandrin C

Catalog No: CFN99708
CAS No: 61301-33-5
Price: $128/20mg
Vicenin -3

Catalog No: CFN92032
CAS No: 59914-91-9
Price: $198/20mg
Sophoricoside

Catalog No: CFN90148
CAS No: 152-95-4
Price: $40/20mg
Dihydroevocarpine

Catalog No: CFN92786
CAS No: 15266-35-0
Price: $268/10mg
Timosaponin BII

Catalog No: CFN98150
CAS No: 136656-07-0
Price: $50/20mg
Zeaxanthin

Catalog No: CFN90234
CAS No: 144-68-3
Price: $ / mg
Biochanin A

Catalog No: CFN99734
CAS No: 491-80-5
Price: $40/20mg
Tags: buy 6-beta-Hydroxyhyoscyamine | 6-beta-Hydroxyhyoscyamine supplier | purchase 6-beta-Hydroxyhyoscyamine | 6-beta-Hydroxyhyoscyamine cost | 6-beta-Hydroxyhyoscyamine manufacturer | order 6-beta-Hydroxyhyoscyamine | 6-beta-Hydroxyhyoscyamine distributor