ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
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More articles cited ChemFaces products.
Chem Biol Interact.2018 Mar 1;Am J Chin Med.2016;44(6)Front Pharmacol. 2017 Apr 25;Anal Bioanal Chem.2018 Feb;Inflammation. 2015 Feb 6.
Sci Rep. 2018 Jan 11;Separation Science and Technology2016 Mar,23Cell11 Jan. 2018;J Bone Miner Res. 2017 Jul 26.J of L. Chroma. & Related Tech2017 Apr 21;
Acta Pharmaceutica Sinica B2015 Apr.7.J Ethnopharmacol. 2017 Jan 20;J Nat Prod. 2017 Apr 28;Front Pharmacol. 2016 Nov 30
Our products had been exported to the following research institutions and universities, And still growing.
Monash University (Australia)Universidad de La Salle (Mexico)University of Lodz (Poland)Fraunhofer-Institut für Molekul... (Germany)
Heidelberg University (Germany)Aveiro University (Portugal)John Innes Centre (United Kingdom)University of Wuerzburg (Germany)
Korea Institute of Oriental Medi... (Korea)University of Queensland (Australia)Institute of Chinese Materia Med... (China)
||The oxidation of 7-Ethoxycoumarin, a typical human P450 substrate, is catalyzed by both wild-type and mutant forms of CYP102A1. |
||P450 (e.g. CYP17)|
||The herbs of Citrus reticulata cv. Chachiensis
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Drug Metab Dispos. 2008 Nov;36(11):2166-70. |
|Generation of human metabolites of 7-ethoxycoumarin by bacterial cytochrome P450 BM3.[Pubmed: 18669587]|
|Recently, wild-type and mutant forms of bacterial cytochrome P450 BM3 (CYP102A1) have been found to metabolize various drugs through reactions similar to those catalyzed by human cytochromes P450 (P450s). Therefore, it has been suggested that CYP102A1 may be used to produce large quantities of the metabolites of human P450-catalyzed reactions. |
METHODS AND RESULTS:
In this report, we show that the oxidation of 7-Ethoxycoumarin, a typical human P450 substrate, is catalyzed by both wild-type and mutant forms of CYP102A1. Two major products were produced as a result of O-deethylation and 3-hydroxylation reactions. These results demonstrate that CYP102A1 mutants catalyze the same reactions as human P450s. High noncompetitive intermolecular kinetic deuterium isotope effects were observed for 7-Ethoxycoumarin O-deethylation in the CYP102A1 system.
These results suggest that there is a common mechanism for the oxidation reactions catalyzed by both the bacterial CYP102A1 and human P450 enzymes.