8-Hydroxy-9,10-diisobutyryloxythymol | CAS:22518-08-7

8-Hydroxy-9,10-diisobutyryloxythymol

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Description:

8-Hydroxy-9,10-diisobutyryloxythymol shows cytotoxicity on six cancer cell lines (K562, HT-29, SGC-7901, DU145, MDA-MB-231, U251). 8-Hydroxy-9,10-diisobutyryloxythymol may have antibacterial activity.

Targets:

Antifection

In vitro:

Acta Botanica Yunnanica, 2009, 31(2):190-192.

New Cytotoxic Thymol Derivatives from Inula helianthus-aquatica (Compositae).[Reference: WebLink]

METHODS AND RESULTS:
A new thymol derivative, 8-hydroxy-9,10-dioxyisopropylidenethymol (1), together with three known thymol derivatives 10-hydroxy-8, 9-dioxyisopropylidenethymol (2), 8-Hydroxy-9,10-diisobutyryloxythymol (3) and 8, 10-dihydroxy-9-isobutyryloxy-thymol (4), was isolated from 95% EtOH extract of the flowers of Inula helianthus-aquatica. Their structures were elucidated on the basis of detailed spectroscopic analysis.
CONCLUSIONS:
These compounds showed cytotoxicities on six cancer cell lines (K562, HT-29, SGC-7901, DU145, MDA-MB-231, U251), and compound 2 is the strongest one with IC50s of 4.20-33.12 μmol/L. This is the first time that the cytotoxic thymol derivatives were isolated from this titled plant.

8-Hydroxy-9,10-diisobutyryloxythymol Description

Source:	The flowers of Inula helianthus-aquatica.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Molecules. 2007 Jan 27;12(8):1606-13.

Antibacterial thymol derivatives isolated from Centipeda minima.[Pubmed: 17960076]

METHODS AND RESULTS:
Two new monoterpenoids, 8,10-dihydroxy-9(2)-methylbutyryloxythymol (1) and 10-hydroxy-8,9-dioxyisopropylidene-thymol (2), together with five known thymol derivatives: 8,9,10-trihydroxythymol (3), thymol-beta-glucopyranoside (4), 9-hydroxythymol (5), 8,10-dihydroxy-9-isobutyryloxythymol (6), and 8-Hydroxy-9,10-diisobutyryloxythymol (7), were isolated from Centipeda minima. Their structures were identified by means of spectroscopic analyses. Interestingly, compound 2 is not an extraction artifact according to a close HPLC examination of material after extraction by analytical MeOH at ambient temperature.
CONCLUSIONS:
The antibacterial activities of compounds 1-7 were evaluated against eight microbial strains by the agar dilution method.

Product Name	8-Hydroxy-9,10-diisobutyryloxythymol
Price:
CAS No.:	22518-08-7
Catalog No.:	CFN89511
Molecular Formula:	C₁₈H₂₆O₆
Molecular Weight:	338.39 g/mol
Purity:	>=98%
Type of Compound:	Terpenoids
Physical Desc.:	Powder
Source:	The flowers of Inula helianthus-aquatica.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antibacterial Compound Library Cytotoxic Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9552 mL	14.7759 mL	29.5517 mL	59.1034 mL	73.8793 mL
5 mM	0.591 mL	2.9552 mL	5.9103 mL	11.8207 mL	14.7759 mL
10 mM	0.2955 mL	1.4776 mL	2.9552 mL	5.9103 mL	7.3879 mL
50 mM	0.0591 mL	0.2955 mL	0.591 mL	1.1821 mL	1.4776 mL
100 mM	0.0296 mL	0.1478 mL	0.2955 mL	0.591 mL	0.7388 mL

CFN93010	Thymol	89-83-8	150.2	C₁₀H₁₄O
CFN91994	2-(2'-Hydroxy-4'-methylphenyl)propionic acid	111044-84-9	180.20	C₁₀H₁₂O₃
CFN91995	9-Hydroxythymol	61955-76-8	166.22	C₁₀H₁₄O₂
CFN92999	8,9-Dihydroxy-10-isobutyryloxythymol	107109-97-7	268.31	C₁₄H₂₀O₅
CFN89511	8-Hydroxy-9,10-diisobutyryloxythymol	22518-08-7	338.39	C₁₈H₂₆O₆
CFN90491	5-Isopropyl-2-methylphenol	499-75-2	150.21	C₁₀H₁₄O
CFN98490	Mullilam diol	36150-04-6	188.3	C₁₀H₂₀O₃
CFN98967	p-Menth-8-ene-1,2-diol	57457-97-3	170.3	C₁₀H₁₈O₂