9-Oxoageraphorone | CAS:105181-06-4 | Manufacturer ChemFaces

9-Oxoageraphorone

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Description:

9-Oxoageraphorone has strong acaricidal activity against P. cuniculi in vitro, it also exhibits high insecticidal effects.

In vitro:

Vet.Parasitol.,2014 Jun 16;203(1-2):197-202.

Isolation and identification of acaricidal compounds in Eupatorium adenophorum petroleum ether extract and determination of their acaricidal activity against Psoroptes cuniculi.[Pubmed: 24569033 ]

METHODS AND RESULTS:
We used multiple silica gel column chromatography and thin-layer chromatography coupled with (1)H nuclear magnetic resonance (NMR) and (13)C NMR to separate and identify the active acaricidal ingredients in Eupatorium adenophorum petroleum ether extract. The acaricidal activity of each compound was tested against Psoroptes cuniculi in vitro. Three compounds had strong acaricidal activity against P. cuniculi in vitro. The insecticidal effect of 0.5% compound 9β-hydroxy-ageraphorone was better than the insecticidal effect of fenvalerate, and compounds 9-Oxoageraphorone and 9-oxo-10,11-dehydro-ageraphorone exhibited higher insecticidal effects than 9β-hydroxy-ageraphorone.
CONCLUSIONS:
Thus, the E. adenophorum petroleum ether extract contains an effective composition of acaricides that could potentially be developed as a promising plant-origin acaricide.

In vivo:

Nat Prod Bioprospect. 2014 Dec 12.

Toxicity Assessment of Cadinene Sesquiterpenes from Eupatorium adenophorum in Mice.[Pubmed: 25500813]

METHODS AND RESULTS:
We firstly tested median lethal dose (LD50) in mice of three cadinene sesquiterpenes 2-deoxo-2-(acetyloxy)-9-Oxoageraphorone (DAOA), 9-oxoagerophorone (OA) and 9-oxo-10,11-dehydro-agerophorone (ODA) from Eupatorium adenophorum (Ea). DAOA (215-4640 mg/kg BW, given orally) showed lowest LD50 at 926 mg/kg BW for male mice in contrast with 9-oxoagerophorone (1470 mg/kg BW) and ODA (1470 mg/kg BW).
CONCLUSIONS:
In sub-acute study, repeated doses (75-300 mg/kg BW, for 7 days) of DAOA/9-oxoagerophorone increased blood parameters, liver and spleen index in dose dependent relationship, along with decrease in thymus index. 75 mg/kg dose of DAOA/9-oxoagerophorone was found to be approximately/totally safe over the span of 7 days treatment showing no change in all above described parameters.

9-Oxoageraphorone Description

Source:	The herbs of Eupatorium adenophorum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	9-Oxoageraphorone
Price:
CAS No.:	105181-06-4
Catalog No.:	CFN99071
Molecular Formula:	C₁₅H₂₂O₂
Molecular Weight:	234.3 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Powder
Source:	The herbs of Eupatorium adenophorum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Insecticides Compound Library Acaricidal Compound Library Sesquiterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.268 mL	21.3402 mL	42.6803 mL	85.3606 mL	106.7008 mL
5 mM	0.8536 mL	4.268 mL	8.5361 mL	17.0721 mL	21.3402 mL
10 mM	0.4268 mL	2.134 mL	4.268 mL	8.5361 mL	10.6701 mL
50 mM	0.0854 mL	0.4268 mL	0.8536 mL	1.7072 mL	2.134 mL
100 mM	0.0427 mL	0.2134 mL	0.4268 mL	0.8536 mL	1.067 mL

CFN96414	Ylangenyl acetate	90039-63-7	262.39	C₁₇H₂₆O₂
CFN96415	Ylangenol	41610-69-9	220.35	C₁₅H₂₄O
CFN97146	10(14)-Cadinene-4,5-diol	672336-50-4	238.4	C₁₅H₂₆O₂
CFN98278	Isocalamendiol	25330-21-6	238.4	C₁₅H₂₆O₂
CFN96767	10-O-Acetylisocalamendiol	1432064-69-1	280.40	C₁₇H₂₈O₃
CFN98081	4-Cadinen-7-ol	217650-27-6	222.4	C₁₅H₂₆O
CFN95246	(-)-Cadin-4,10(15)-dien-11-oic acid	1124353-23-6	234.3	C₁₅H₂₂O₂
CFN97485	3-Acetoxy-4-cadinen-8-one	923950-05-4	278.4	C₁₇H₂₆O₃
CFN99071	9-Oxoageraphorone	105181-06-4	234.3	C₁₅H₂₂O₂
CFN97514	1,3,5-Cadinatriene-3,8-diol	941227-27-6	234.3	C₁₅H₂₂O₂