ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
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More articles cited ChemFaces products.
ARPN Journal of Eng.& Applied Sci.4, Feb. 2016 Sci Rep. 2017 Jan 9;J Ethnopharmacol. 2017 Jul 12;JPCMarch 16, 2017J Ethnopharmacol. 2017 Feb 23;
Int J Mol Med.2015 Dec 28.Int J Mol Sci. 2017 May 11;Org Biomol Chem. 2017 Jul 25.Research on Crops.Jun 2017;J. Int. J. of Food Properties 13 Feb 2017
Phytochem Anal.2016 Sep;Food Research InternationalJan. 2016Phytomedicine2015 March 20.Scientific Research.2015 Jan 6; 14-23
Our products had been exported to the following research institutions and universities, And still growing.
University of Limpopo (South Africa)Universidade do Porto (Portugal)Melbourne University (Australia)John Innes Centre (United Kingdom)
University of East Anglia (United Kingdom)Kyoto University (Japan)University of Parma (Italy)National Chung Hsing University (Taiwan)
Leibniz Institute of Plant Bioch... (Germany)Srinakharinwirot University (Thailand)University of British Columbia (Canada)
|| 9-Methoxycanthin-6-one-N-oxide shows cytotoxic activity against a panel of cell lines comprising a number of human cancer cell types.|
|J Nat Prod. 1991 Sep-Oct;54(5):1360-7. |
|Cytotoxic and antimalarial constituents of the roots of Eurycoma longifolia.[Pubmed: 1800638]|
METHODS AND RESULTS:
By bioactivity-directed fractionation, five cytotoxic constituents have been characterized from the roots of Eurycoma longifolia collected in Kalimantan, Indonesia. Four canthin-6-one alkaloids, namely, 9-methoxycanthin-6-one, 9-Methoxycanthin-6-one-N-oxide, 9-hydroxycanthin-6-one, and 9-hydroxycanthin-6-one-N-oxide, and one quassinoid, eurycomanone, were found to be cytotoxic principles. Each of these compounds was evaluated against a panel of cell lines comprising a number of human cancer cell types [breast, colon, fibrosarcoma, lung, melanoma, KB, and KB-V1 (a multi-drug resistant cell line derived from KB)] and murine lymphocytic leukemia (P-388). The canthin-6-ones 1-4 were found to be active with all cell lines tested except for the KB-V1 cell line.
Eurycomanone was inactive against murine lymphocytic leukemia (P-388) but was significantly active against the human cell lines tested. Two additional isolates, the beta-carboline alkaloids beta-carboline-1-propionic acid and 7-methoxy-beta-carboline-1-propionic acid, were not significantly active with these cultured cells. However, compounds 5 and 7 were found to demonstrate significant antimalarial activity as judged by studies conducted with cultured Plasmodium falciparum strains. The structures of the novel compounds 2-4 and 7 were established by spectral and chemical methods.
||The barks of Ailanthus altissima
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Natural Medicines, 2002 , 56 :55-58 |
|Canthin-6-one alkaloids from callus cultures of Eurycoma longifolia.[Reference: WebLink]|
METHODS AND RESULTS:
Four alkaloids, 9-methoxycanthin-6-one, 9-hydroxycanthin-6-one, 5,9-dimethoxycanthin-6-one and 9-Methoxycanthin-6-one-N-oxide were isolated from the callus cultures of Eurycoma longifolia (Simaroubaceae).
Their structures were based on analyses of spectroscopic data.