|Description:|| 1. 9-Methoxycanthin-6-one-N-oxide shows cytotoxic activity against a panel of cell lines comprising a number of human cancer cell types.|
|Source:||The barks of Ailanthus altissima|
|Solvent:||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||3.7552 mL||18.7758 mL||37.5516 mL||75.1033 mL||93.8791 mL|
|5 mM||0.751 mL||3.7552 mL||7.5103 mL||15.0207 mL||18.7758 mL|
|10 mM||0.3755 mL||1.8776 mL||3.7552 mL||7.5103 mL||9.3879 mL|
|50 mM||0.0751 mL||0.3755 mL||0.751 mL||1.5021 mL||1.8776 mL|
|100 mM||0.0376 mL||0.1878 mL||0.3755 mL||0.751 mL||0.9388 mL|
J Nat Prod. 1991 Sep-Oct;54(5):1360-7.
|Cytotoxic and antimalarial constituents of the roots of Eurycoma longifolia.[Pubmed: 1800638]|
|By bioactivity-directed fractionation, five cytotoxic constituents have been characterized from the roots of Eurycoma longifolia collected in Kalimantan, Indonesia. Four canthin-6-one alkaloids, namely, 9-methoxycanthin-6-one, 9-Methoxycanthin-6-one-N-oxide, 9-hydroxycanthin-6-one, and 9-hydroxycanthin-6-one-N-oxide, and one quassinoid, eurycomanone, were found to be cytotoxic principles. Each of these compounds was evaluated against a panel of cell lines comprising a number of human cancer cell types [breast, colon, fibrosarcoma, lung, melanoma, KB, and KB-V1 (a multi-drug resistant cell line derived from KB)] and murine lymphocytic leukemia (P-388). The canthin-6-ones 1-4 were found to be active with all cell lines tested except for the KB-V1 cell line. Eurycomanone was inactive against murine lymphocytic leukemia (P-388) but was significantly active against the human cell lines tested. Two additional isolates, the beta-carboline alkaloids beta-carboline-1-propionic acid and 7-methoxy-beta-carboline-1-propionic acid, were not significantly active with these cultured cells. However, compounds 5 and 7 were found to demonstrate significant antimalarial activity as judged by studies conducted with cultured Plasmodium falciparum strains. The structures of the novel compounds 2-4 and 7 were established by spectral and chemical methods.|
Natural Medicines, 2002 , 56 :55-58
|Canthin-6-one alkaloids from callus cultures of Eurycoma longifolia[Reference: WebLink]|
|Four alkaloids, 9-methoxycanthin-6-one, 9-hydroxycanthin-6-one, 5,9-dimethoxycanthin-6-one and 9-Methoxycanthin-6-one-N-oxide were isolated from the callus cultures of Eurycoma longifolia (Simaroubaceae). Their structures were based on analyses of spectroscopic data.|