Science | Nature | Cell | View More
Natural Products
Acuminatin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Acuminatin
Price: $413 / 5mg
CAS No.: 41744-39-2
Catalog No.: CFN98656
Molecular Formula: C21H24O4
Molecular Weight: 340.4 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Solid
Source: The roots of Daphne odora.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $351.1 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Kamphaengphet Rajabhat University (Thailand)
  • Donald Danforth Plant Science C... (USA)
  • Griffith University (Australia)
  • The Institute of Cancer Research (United Kingdom)
  • Tohoku University (Japan)
  • Calcutta University (India)
  • University of Leipzig (Germany)
  • Hamdard University (India)
  • Chiang Mai University (Thailand)
  • Monash University Malaysia (Malaysia)
  • Michigan State University (USA)
  • More...
Package
Featured Products
Linderane

Catalog No: CFN98175
CAS No: 13476-25-0
Price: $70/20mg
Coixol

Catalog No: CFN98889
CAS No: 532-91-2
Price: $40/20mg
Fisetin

Catalog No: CFN98176
CAS No: 528-48-3
Price: $30/20mg
L-Alanine

Catalog No: CFN70145
CAS No: 56-41-7
Price: $30/20mg
Imperatorin

Catalog No: CFN98758
CAS No: 482-44-0
Price: $40/20mg
Quercetin-3-o-rutinose

Catalog No: CFN92447
CAS No: 949926-49-2
Price: $ / mg
Isosteviol

Catalog No: CFN90544
CAS No: 27975-19-5
Price: $40/20mg
Cannabidiolic acid

Catalog No: CFN99356
CAS No: 1244-58-2
Price: $413/5mg
Myricetin

Catalog No: CFN98877
CAS No: 529-44-2
Price: $40/20mg
Brucine sulfate

Catalog No: CFN90316
CAS No: 4845-99-2
Price: $50/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: (-)-Acuminatin exerts hepatoprotective activities, perhaps by serving as a potent antioxidant. (+)-trans-Acuminatin, and (+)-cis-acuminatin show weak activity against platelet aggregation with IC50 values of 108.5 and 90.02 uM, respectively.(-)-Acuminatin, and machilin G show dose-dependent potent inhibitory activities against PLCgamma1 in vitro with IC50 values ranging from 8.8 to 26.0 microM, the inhibition of PLCgamma1 may be an important mechanism for an antiproliferative effect on the human cancer cells, therefore, these inhibitors may be utilized as cancer chemotherapeutic and chemopreventive agents.
Targets: PAFR | PLCgamma1
In vitro:
J Pharm Pharmacol. 2000 Sep;52(9):1163-9.
Antioxidant lignans from Machilus thunbergii protect CCl4-injured primary cultures of rat hepatocytes.[Pubmed: 11045899]

METHODS AND RESULTS:
Eleven lignans (1-11) were isolated from the CH2Cl2 fraction of the bark of Machilus thunbergii Sieb. et Zucc. (Lauraceae). These were identified as (-)-Acuminatin (1), (-)-isoguaiacin (2), meso-dihydroguaiaretic acid (3), (+)-galbacin (4), (-)-sesamin (5), (+)-galbelgin (6), machilin A (7), machilin G (8), licarin A (9), and nectandrin A (10) and B (11). Primary cultures of rat hepatocytes were co-incubated for 90 min with the hepatotoxin CCl4 and each of the 11 lignans (50 microM). Hepatoprotective activity was determined by measuring the level of glutamic pyruvic transaminase released into the medium from the primary cultures of rat hepatocytes. (-)-Acuminatin, (-)-isoguaiacin and meso-dihydroguaiaretic acid all significantly reduced the level of glutamic pyruvic transaminase released. Further investigation revealed that these three compounds significantly preserved the levels and the activities of glutathione, superoxide dismutase, glutathione peroxidase and catalase. (-)-Acuminatin, (-)-isoguaiacin and meso-dihydroguaiaretic acid also ameliorated lipid peroxidation as demonstrated by a reduction of malondialdehyde production.
CONCLUSIONS:
These results suggest that (-)-Acuminatin, (-)-isoguaiacin and meso-dihydroguaiaretic acid exert diverse hepatoprotective activities, perhaps by serving as potent antioxidants.
Phytochemistry. 2016 Sep;129:36-44.
Amides and neolignans from the aerial parts of Piper bonii[Pubmed: 27452451 ]

METHODS AND RESULTS:
Six amides, piperbonamides A-F, three neolignans piperbonins A-C, and 11 known compounds were isolated from the aerial parts of Piper bonii (Piperaceae). The structures of piperbonamides A-F and piperbonins A-C were elucidated based on the analysis of 1D and 2D NMR and MS data.
CONCLUSIONS:
Piperbonin A, (+)-trans-Acuminatin, (+)-cis-Acuminatin, (+)-kadsurenone, and pipernonaline showed weak activity against platelet aggregation with IC50 values of 118.2, 108.5, 90.02, 107.3, and 116.3 μM, respectively, as compared with the positive control, tirofiban, with an IC50 value of 5.24 μM. Piperbonamides A-F were inactive against five tumor cell lines at concentrations up to 40 μM.
Acuminatin Description
Source: The roots of Daphne odora.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Caffeoylcalleryanin

Catalog No: CFN95532
CAS No: 20300-49-6
Price: $318/10mg
Cichoriin

Catalog No: CFN95196
CAS No: 531-58-8
Price: $100/20mg
Campneoside II

Catalog No: CFN95498
CAS No: 95587-86-3
Price: $318/10mg
Resinacein D

Catalog No: CFN95591
CAS No: 2231061-47-3
Price: $413/5mg
Methyl ganoderate E

Catalog No: CFN95582
CAS No: 98718-43-5
Price: $413/5mg
Stevia impurity (13-[(2-O-6-deoxy-...

Catalog No: CFN95229
CAS No: 1309929-72-3
Price: $463/5mg
Calleryanin

Catalog No: CFN95556
CAS No: 20300-53-2
Price: $318/5mg
Apigenin 7-O-(6''-O-malonylglucosi...

Catalog No: CFN95163
CAS No: 86546-87-4
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9377 mL 14.6886 mL 29.3772 mL 58.7544 mL 73.443 mL
5 mM 0.5875 mL 2.9377 mL 5.8754 mL 11.7509 mL 14.6886 mL
10 mM 0.2938 mL 1.4689 mL 2.9377 mL 5.8754 mL 7.3443 mL
50 mM 0.0588 mL 0.2938 mL 0.5875 mL 1.1751 mL 1.4689 mL
100 mM 0.0294 mL 0.1469 mL 0.2938 mL 0.5875 mL 0.7344 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Arch Pharm Res. 2004 Oct;27(10):1043-7.
Inhibition of phospholipase Cγ1 and cancer cell proliferation by lignans and flavans from Machilus thunbergii[Pubmed: 15554262]
Thirteen compounds were isolated from the CH2Cl2 fraction of Machilus thunbergii as phospholipase Cgamma1 (PLCgamma1) inhibitors.
METHODS AND RESULTS:
These compounds were identified as nine lignans, two neolignans, and two flavans by spectroscopic analysis. Of these, 5,7-di-O-methyl-3',4'-methylenated (-)-epicatechin (12) and 5,7,3'-tri-O-methyl (-)-epicatechin (13) have not been reported previously in this plant. In addition, seven compounds, machilin A (1), (-)-sesamin (3), machilin G (5), (+)-galbacin (9), licarin A (10), (-)-Acuminatin (11) and compound 12 showed dose-dependent potent inhibitory activities against PLCgamma1 in vitro with IC50 values ranging from 8.8 to 26.0 microM. These lignans, neolignans, and flavans are presented as a new class of PLCgamma1 inhibitors.
CONCLUSIONS:
The brief study of the structure activity relationship of these compounds suggested that the benzene ring with the methylene dioxy group is responsible for the expression of inhibitory activities against PLCgamma1. Moreover, it is suggested that inhibition of PLCgamma1 may be an important mechanism for an antiproliferative effect on the human cancer cells. Therefore, these inhibitors may be utilized as cancer chemotherapeutic and chemopreventive agents.
Linderane

Catalog No: CFN98175
CAS No: 13476-25-0
Price: $70/20mg
Coixol

Catalog No: CFN98889
CAS No: 532-91-2
Price: $40/20mg
Fisetin

Catalog No: CFN98176
CAS No: 528-48-3
Price: $30/20mg
L-Alanine

Catalog No: CFN70145
CAS No: 56-41-7
Price: $30/20mg
Imperatorin

Catalog No: CFN98758
CAS No: 482-44-0
Price: $40/20mg
Quercetin-3-o-rutinose

Catalog No: CFN92447
CAS No: 949926-49-2
Price: $ / mg
Isosteviol

Catalog No: CFN90544
CAS No: 27975-19-5
Price: $40/20mg
Cannabidiolic acid

Catalog No: CFN99356
CAS No: 1244-58-2
Price: $413/5mg
Myricetin

Catalog No: CFN98877
CAS No: 529-44-2
Price: $40/20mg
Brucine sulfate

Catalog No: CFN90316
CAS No: 4845-99-2
Price: $50/20mg
Tags: buy Acuminatin | Acuminatin supplier | purchase Acuminatin | Acuminatin cost | Acuminatin manufacturer | order Acuminatin | Acuminatin distributor