Science | Nature | Cell | View More
Natural Products
Ailanthone
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Ailanthone
Price: $318 / 20mg
CAS No.: 981-15-7
Catalog No.: CFN97561
Molecular Formula: C20H24O7
Molecular Weight: 376.4 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The barks of Ailanthus altissima
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $96.2 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of Vienna (Austria)
  • University of Madras (India)
  • Kazusa DNA Research Institute (Japan)
  • Georgia Institute of Technology (USA)
  • University of Melbourne (Australia)
  • Heinrich-Heine-University Düss... (Germany)
  • Monash University Malaysia (Malaysia)
  • Universidad de Ciencias y Artes... (Mexico)
  • Universidad Veracuzana (Mexico)
  • Complutense University of Madrid (Spain)
  • Cancer Research Initatives Foun... (Malaysia)
  • More...
Package
Featured Products
Saponarin

Catalog No: CFN90134
CAS No: 20310-89-8
Price: $288/10mg
Angelicin

Catalog No: CFN98854
CAS No: 523-50-2
Price: $30/20mg
Biochanin A

Catalog No: CFN99734
CAS No: 491-80-5
Price: $40/20mg
Peiminine

Catalog No: CFN99997
CAS No: 18059-10-4
Price: $60/20mg
Retronecine

Catalog No: CFN00322
CAS No: 480-85-3
Price: $ /
Ampelopsin

Catalog No: CFN98326
CAS No: 27200-12-0
Price: $30/20mg
Hypaconitine

Catalog No: CFN99200
CAS No: 6900-87-4
Price: $98/20mg
Bornyl acetate

Catalog No: CFN90494
CAS No: 5655-61-8
Price: $30/20mg
Baicalin

Catalog No: CFN99111
CAS No: 21967-41-9
Price: $40/20mg
Ginsenoside MC

Catalog No: CFN95232
CAS No: 175484-06-7
Price: $318/10mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Ailanthone has anti-inflammatory, anti-HIV, anti-malarial, anti-allergic, antiulcer and antimicrobial activities; it also has potent antineoplastic activity against hepatocellular carcinoma (HCC), it can inhibit huh7 cancer cell growth via cell cycle arrest and apoptosis in vitro and in vivo. Ailanthone has significant pre-emergence herbicide activity , is directly correlated to Ailanthone concentration.
Targets: HIV | Antifection
In vitro:
Plant & Soil, 2003, 256(1):85-99.
Herbicidal effects under field conditions of Ailanthus altissima bark extract, which contains ailanthone.[Reference: WebLink]

METHODS AND RESULTS:
These application rates provided herbicidal activity equivalent to 4.5, 2.2, 1.1, 0.6, 0.3, and 0.0 kg of pure Ailanthone per hectare, based on the results of a laboratory bioassay of extract and pure Ailanthone. Strong herbicidal effects were observed within several days. Even the lowest rate caused mortality and injury in excess of 50% for nine of the 17 species, and a significant reduction in shoot biomass for 13 species. The second field trial tested the ability of bark extract to control weeds under field conditions with horticultural crops (bush bean, cauliflower, sweet corn, tomato). A. altissima bark extract was sprayed post-emergence at rates of 99, 50, 26, 13, and 0 kg ha–1, providing herbicidal activity equivalent to 1.1, 0.6, 0.3, 0.14, and 0.0 kg of pure Ailanthone per hectare. Extract treatment provided partial weed control (greatest reduction in weed biomass was 40%), but also caused serious crop injury. Bush bean was the only crop that showed a significant increase in shoot biomass and fruit yield, compared to the non-weeded control.
CONCLUSIONS:
None of the crops, regardless of application rate, showed a level of shoot biomass or fruit yield comparable to the hand-weeded control. The herbicidal effects of A. altissima bark extract declined within the first few weeks after application, supporting previous evidence that Ailanthone is rapidly degraded under field conditions.
In vivo:
Anticancer Res. 1988 Jul-Aug;8(4):573-9.
Antitumor activity of novel ailanthone derivatives in vitro and in vivo.[Pubmed: 3178149]
The antitumor activities of two Ailanthone derivatives with 15 beta-acyloxy side chains were investigated.
METHODS AND RESULTS:
The cytotoxic activity of 11 beta, 20-epoxy-1 beta, 11 alpha, 12 alpha-trihydroxy-15-beta-[E)-3-methyl-2-octenoyl) oxypicras-3,13(21)-diene-2,16-dione (SUN2071) and 11 beta, 20-epoxy-1 beta, 11 alpha, 12 alpha-trihydroxy-15 beta-[E)-2-undecenoyl) oxypicras-3,13(21)-diene-2,16-dione (SUN0237) was close to that of bruceantin and vincristine. SUN2071 was shown to be a potent inhibitor of protein synthesis in L1210 cultured cells. When administered i.p. to i.p. inoculated P388 leukemia mice, daily treatment with SUN2071 and SUN0237 significantly increased the lifespan (increases in lifespan in excess of 100% were achieved). These increases were comparable to those achieved with vincristine. The therapeutic ratio of SUN2071 was also close to that of vincristine. However, the compounds were ineffective when administered as a single injection. Daily i.p. treatment with SUN2071 demonstrated significant tumor growth inhibition in mice inoculated s.c. with colon-38 and moderate activity against i.p. L1210 leukemia and i.p. B16 melanoma. The compounds were ineffective when tested against the Lewis lung carcinoma and colon-26.
CONCLUSIONS:
In a preliminary toxicological study, SUN2071 at a therapeutic dose in daily consecutive i.p. injection produced leucopenia.
Farmaco Sci. 1981 Feb;36(2):116-22.
Antiamebic properties of some derivatives of ailantone and quassin.[Pubmed: 7227501]
Owing to its high toxicity, Ailanthone, one of the most potent in vivo amoebicidal drugs of natural origin, cannot be safely employed in clinical trials. With the aim of obtaining a compound with a better therapeutic index and of studying possible relationships between biological activity and chemical structure, many derivatives of Ailanthone and of the chemically related, although biologically inactive, quassin have been prepared and tested.
Ailanthone Description
Source: The barks of Ailanthus altissima
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
3'-Hydroxy-5,7,4'-trimethoxyflavon...

Catalog No: CFN95396
CAS No: 33554-52-8
Price: $318/5mg
12beta-Acetoxy-3beta-hydroxy-7,11,...

Catalog No: CFN95468
CAS No: 1085338-75-5
Price: $318/5mg
Clemomandshuricoside B

Catalog No: CFN95302
CAS No: 905294-48-6
Price: $318/10mg
Octyl 3-(4-hydroxyphenyl)prop-2-en...

Catalog No: CFN95563
CAS No: N/A
Price: $318/5mg
Mahuannin J

Catalog No: CFN95533
CAS No: N/A
Price: $318/5mg
Dioscoreside E

Catalog No: CFN95346
CAS No: 435321-73-6
Price: $318/5mg
Isophysalin G

Catalog No: CFN95328
CAS No: 152221-21-1
Price: $368/5mg
cis-Aegineoside

Catalog No: CFN95295
CAS No: N/A
Price: $413/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6567 mL 13.2837 mL 26.5675 mL 53.135 mL 66.4187 mL
5 mM 0.5313 mL 2.6567 mL 5.3135 mL 10.627 mL 13.2837 mL
10 mM 0.2657 mL 1.3284 mL 2.6567 mL 5.3135 mL 6.6419 mL
50 mM 0.0531 mL 0.2657 mL 0.5313 mL 1.0627 mL 1.3284 mL
100 mM 0.0266 mL 0.1328 mL 0.2657 mL 0.5313 mL 0.6642 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Sci Rep. 2015; 5: 16185.
Ailanthone Inhibits Huh7 Cancer Cell Growth via Cell Cycle Arrest and Apoptosis In Vitro and In Vivo.[Pubmed: 26525771]
While searching for natural anti-hepatocellular carcinoma (HCC) components in Ailanthus altissima, we discovered that Ailanthone had potent antineoplastic activity against HCC. However, the molecular mechanisms underlying the antitumor effect of Ailanthone on HCC have not been examined. In this study, the antitumor activity and the underlying mechanisms of Ailanthone were evaluated in vitro and in vivo.
METHODS AND RESULTS:
Mechanistic studies showed that Ailanthone induced G0/G1-phase cell cycle arrest, as indicated by decreased expression of cyclins and CDKs and increased expression of p21 and p27. Our results demonstrated that Ailanthone triggered DNA damage characterized by activation of the ATM/ATR pathway. Moreover, Ailanthone-induced cell death was associated with apoptosis, as evidenced by an increased ratio of cells in the subG1 phase and by PARP cleavage and caspase activation. Ailanthone-induced apoptosis was mitochondrion-mediated and involved the PI3K/AKT signaling pathway in Huh7 cells. In vivo studies demonstrated that Ailanthone inhibited the growth and angiogenesis of tumor xenografts without significant secondary adverse effects, indicating its safety for treating HCC.
CONCLUSIONS:
In conclusion, our study is the first to report the efficacy of Ailanthone against Huh7 cells and to elucidate its underlying molecular mechanisms. These findings suggest that Ailanthone is a potential agent for the treatment of liver cancer.
Structure Identification:
Nat Prod Commun. 2011 May;6(5):593-6.
Herbicide activity of extracts from Ailanthus altissima (Simaroubaceae).[Pubmed: 21615014]
The purpose of the present study was to isolate and characterize Ailanthone-rich materials from the bark of the deciduous tree Ailanthus altissima (Mill.) Swingle and to assess their herbicide activity on selected herbaceous species.
METHODS AND RESULTS:
Ailanthone-rich fractions were obtained from A. altissima bark by extraction with dichloromethane and ethyl acetate and subsequent purification of these crude extracts, and of the remaining water mixture after solvent extraction, by means of gel permeation chromatography. A number of fractions were isolated and characterized for Ailanthone content. A dichloromethane fraction was shown to contain 92% w/w of Ailanthone, as demonstrated by HPLC and NMR analysis. A significant pre-emergence herbicide activity was found for most of the extracts which was directly correlated to Ailanthone concentration. A remarkable combined pre- and post-emergence herbicide activity was found for a specific fraction.
CONCLUSIONS:
These results indicate that the bark of A. altissima may represent an interesting source for the production of natural herbicides for use in agriculture.
Saponarin

Catalog No: CFN90134
CAS No: 20310-89-8
Price: $288/10mg
Angelicin

Catalog No: CFN98854
CAS No: 523-50-2
Price: $30/20mg
Biochanin A

Catalog No: CFN99734
CAS No: 491-80-5
Price: $40/20mg
Peiminine

Catalog No: CFN99997
CAS No: 18059-10-4
Price: $60/20mg
Retronecine

Catalog No: CFN00322
CAS No: 480-85-3
Price: $ /
Ampelopsin

Catalog No: CFN98326
CAS No: 27200-12-0
Price: $30/20mg
Hypaconitine

Catalog No: CFN99200
CAS No: 6900-87-4
Price: $98/20mg
Bornyl acetate

Catalog No: CFN90494
CAS No: 5655-61-8
Price: $30/20mg
Baicalin

Catalog No: CFN99111
CAS No: 21967-41-9
Price: $40/20mg
Ginsenoside MC

Catalog No: CFN95232
CAS No: 175484-06-7
Price: $318/10mg
Tags: buy Ailanthone | Ailanthone supplier | purchase Ailanthone | Ailanthone cost | Ailanthone manufacturer | order Ailanthone | Ailanthone distributor