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Asebotin
Asebotin
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Asebotin
Price:
CAS No.: 11075-15-3
Catalog No.: CFN96929
Molecular Formula: C22H26O10
Molecular Weight: 450.44 g/mol
Purity: >=98%
Type of Compound: Chalcones
Physical Desc.: Powder
Source: The leaves of Pieris japonica.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Asebotin shows anti-influenza A virus activity, it also possesses potent antiviral activity (100% inhibition at the concentration of 1 ug /mL) against highly pathogenic avian influenza strain H5N1. Asebotin can inhibit the proliferation of murine B cells.
Targets: Influenza virus
In vitro:
Nat Prod Res. 2014;28(6):377-82.
Anti-influenza A virus activity of a new dihydrochalcone diglycoside isolated from the Egyptian seagrass Thalassodendron ciliatum (Forsk.) den Hartog.[Pubmed: 24443884]

METHODS AND RESULTS:
One new dihydrochalcone diglycoside has been isolated from the EtOAc fraction of the Egyptian seagrass Thalassodendrin ciliatum (Forsk.) den Hartog, and was identified as 6'-O-rhamnosyl-(1‴ → 6″)-glucopyranosyl asebogenin for which a trivial name Thalassodendrone was established. Furthermore, five known phenolics were isolated and identified as Asebotin, quercetin 3,7-diglucoside, protocatechuic acid, ferulic acid and p-hydroxybenzoic acid. The structures of all the isolated compounds were established based on 1D and 2D NMR spectroscopy and high-resolution-mass spectrometer. High-resolution electrospray ionization mass spectra (HR-ESI-MS) were obtained using a JEOL JMS-T100TD spectrometer (JEOL Ltd., Tokyo, Japan).
CONCLUSIONS:
The anti-influenza A virus activity of the isolated new compound and Asebotin was evaluated, and the obtained results revealed that the inhibition dose concentration of Asebotin was more than that of Thalassodendrone with IC50 = 2.00 and 1.96 μg/mL, respectively, and with cytotoxic concentration (CC50) of 3.36 and 3.14 μg/mL, respectively.
Nat Prod Res. 2013;27(18):1625-32.
Anti-H5N1 virus new diglyceride ester from the Red Sea grass Thallasodendron ciliatum.[Pubmed: 23163517 ]

METHODS AND RESULTS:
Some Egyptian plants were screened against highly pathogenic avian influenza strain H5N1 using plaque inhibition assay in Madin-Darby canine kidney. The results indicated that the extracts of Red Sea grass Thallasodendron ciliatum possessed potent antiviral activity (100% inhibition at the concentration of 1 μg mL⁻1). The bioactivity-guided fractionations led to the isolation of a new diglyceride ester (1) along with Asebotin (2) for the first time from the plant.
CONCLUSIONS:
The two isolates showed reduction of virus titre by 67.26% and 53.81% inhibition at concentration of 1 ng mL⁻1, respectively.
Asebotin Description
Source: The leaves of Pieris japonica.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

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IF=12.804(2019)

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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.2201 mL 11.1003 mL 22.2005 mL 44.401 mL 55.5013 mL
5 mM 0.444 mL 2.2201 mL 4.4401 mL 8.8802 mL 11.1003 mL
10 mM 0.222 mL 1.11 mL 2.2201 mL 4.4401 mL 5.5501 mL
50 mM 0.0444 mL 0.222 mL 0.444 mL 0.888 mL 1.11 mL
100 mM 0.0222 mL 0.111 mL 0.222 mL 0.444 mL 0.555 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Nat Prod. 2005 Mar;68(3):392-6.
Dihydrochalcones from the leaves of Pieris japonica.[Pubmed: 15787442 ]

METHODS AND RESULTS:
Six new dihydrochalcones, 3-hydroxyAsebotin (5), asebogenin 2'-O-beta-D-ribohexo-3-ulopyranoside (6), 2' '-acetylAsebotin (7), 3',4,5'-trihydroxy-4'-methoxydihydrochalcone 3',5'-di-O-beta-D-glucopyranoside (8), and pierotins A (9) and B (10), along with four known dihydrochalcones, phloretin (1), phlorizin (2), asebogenin (3), and Asebotin (4), were isolated from the leaves of Pieris japonica. Their structures were elucidated on the basis of spectroscopic analysis including HMQC, HMBC, NOESY, and X-ray crystal diffraction.
CONCLUSIONS:
Compounds 1, 3-5, and 7-10 inhibited the proliferation of murine B cells and compounds 5 and 10 inhibited the proliferation of murine T cells in vitro significantly.
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Diosgenin

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Procyanidin B2

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Piperine

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Ginsenoside Rg5

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Paeoniflorin

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Price: $30/20mg
Phyllanthin

Catalog No: CFN99050
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Price: $288/10mg
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