|Description:|| 1. Asperulosidic acid has been recently used in chinese medicine as a useful drug against some tumors.|
2. Asperulosidic acid has anticlastogenic activity, since the anticlastogenic irridoids have an alpha-unsaturated carbonyl group, this structure is considered to play an important role in the anticlastogenicity.
3. Asperulosidic acid, and 6-O-(beta-D-glucopyranosyl)-1-O-octanoyl-beta-D-glucopyranose are effective in suppressing 12-O-tedtradecanoylphorbol-13-acetate (TPA)- or epidermal growth factor (EGF)-induced cell transformation and associated AP-1 activity.
4. Asperulosidic acid can inhibit the seed germination and growth of seedlings of large crabgrass.
|Targets:||EGFR | AP-1|
|Source:||The herbs of Hedyotis diffusa Willd.|
|Solvent:||DMSO, Pyridine, Methanol, Ethanol, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||2.3127 mL||11.5634 mL||23.1267 mL||46.2535 mL||57.8168 mL|
|5 mM||0.4625 mL||2.3127 mL||4.6253 mL||9.2507 mL||11.5634 mL|
|10 mM||0.2313 mL||1.1563 mL||2.3127 mL||4.6253 mL||5.7817 mL|
|50 mM||0.0463 mL||0.2313 mL||0.4625 mL||0.9251 mL||1.1563 mL|
|100 mM||0.0231 mL||0.1156 mL||0.2313 mL||0.4625 mL||0.5782 mL|
Yakugaku Zasshi. 1981 Jul;101(7):657-9.
|Two novel glycosides from the fruits of Morinda citrifolia (noni) inhibit AP-1 transactivation and cell transformation in the mouse epidermal JB6 cell line.[Pubmed: 11479211]|
|The fruit juice of Morinda citrifolia (noni), a plant originally grown in the Hawaiian and Tahitian islands, has long been used by islanders to treat diseases, including cancer. Two novel glycosides, 6-O-(beta-D-glucopyranosyl)-1-O-octanoyl-beta-D-glucopyranose and Asperulosidic acid, extracted from the juice of noni fruits, were used to examine their effects on 12-O-tedtradecanoylphorbol-13-acetate (TPA)- and epidermal growth factor (EGF)-induced AP-1 transactivation and cell transformation in mouse epidermal JB6 cells. The results indicated that both compounds were effective in suppressing TPA- or EGF-induced cell transformation and associated AP-1 activity. TPA- or EGF-induced phosphorylation of c-Jun, but not extracellular signal-regulated kinases or p38 kinases, was also blocked by the compounds, indicating that c-Jun N-terminal kinases were critical in mediating TPA- or EGF-induced AP-1 activity and subsequent cell transformation in JB6 cells.|
J.Weed Sci.Tech., 1986, 31:280-6.
|Plant Growth Inhibitors in Catchweed Seeds and Their Allelopathy.[Reference: WebLink]|
|Two Asp-related iridoidglucosides, compounds A and B were isolated from the dormant seeds of catchweed. By chemical analysis, compound A was identified as Asperulosidic acid which was derived from Asp through the cleavage of a lactone ring, and compound B as deacetyl Asperulosidic acid produced through the deacetylation of Asperulosidic acid. Asperulosidic acid inhibited the seed germination and growth of seedlings of large crabgrass and alfalfa to the same degree as Asp, but did not inhibit white clover, while deacetyl Asperulosidic acid showed lower inhibitory effect on the tested plants than Asp and Asperulosidic acid. Furthermore, Asperulosidic acid showed similar inhibitory activity to Asp on the germination of catchweed seeds themselves. Since these compounds were only detected in the exudate obtained from the seed coat of catchweed seeds, inhibition of the germination and growth of lettuce placed together with catchweed seeds may be due to iridoidglucosides liberated from the latter seeds which have been soaked in water.|