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Baccatin VIII
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Product Name Baccatin VIII
Price:
CAS No.: 1623410-10-5
Catalog No.: CFN96907
Molecular Formula: C33H42O13
Molecular Weight: 646.68 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The twigs and leaves of Taxus yunnanensis.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Baccatin VIII exhibits inhibitory effects on HL-60 and MCF-7, with IC50 values of 3.44 and 9.67 uM, respectively.
In vitro:
Nat Prod Bioprospect. 2014 Feb;4(1):47-51
New Taxane Diterpenoids from Taxus yunnanensis.[Pubmed: 24660136 ]

METHODS AND RESULTS:
Three hitherto unknown taxane diterpenoids, namely Baccatin VIII (1), baccatin IX (2), and baccatin X (3), along with 10 known analogues were isolated from an ethanolic extract of the twigs and leaves of Taxus yunnanensis. The new structures were characterized based on extensive spectroscopic analysis.
CONCLUSIONS:
Compounds 1 and 2 were tested for their in vitro cytotoxicity against five human tumor cell lines, and 1 exhibited inhibitory effects on HL-60 and MCF-7, with IC50 values of 3.44 and 9.67 μM, respectively.
Baccatin VIII Description
Source: The twigs and leaves of Taxus yunnanensis.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
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PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.5464 mL 7.7318 mL 15.4636 mL 30.9272 mL 38.659 mL
5 mM 0.3093 mL 1.5464 mL 3.0927 mL 6.1854 mL 7.7318 mL
10 mM 0.1546 mL 0.7732 mL 1.5464 mL 3.0927 mL 3.8659 mL
50 mM 0.0309 mL 0.1546 mL 0.3093 mL 0.6185 mL 0.7732 mL
100 mM 0.0155 mL 0.0773 mL 0.1546 mL 0.3093 mL 0.3866 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Oxypeucedanin hydrate

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Catharanthine

Catalog No: CFN99765
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Price: $40/20mg
(+)-Camphor

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CAS No: 464-49-3
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Parishin C

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Oleanolic acid

Catalog No: CFN98800
CAS No: 508-02-1
Price: $30/20mg
Crocin II

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Price: $118/20mg
Diosmin

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CAS No: 520-27-4
Price: $30/20mg
Guaijaverin

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Price: $138/20mg
Astragaloside I

Catalog No: CFN99172
CAS No: 84680-75-1
Price: $50/20mg
Ferulic acid

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CAS No: 1135-24-6
Price: $40/20mg
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