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Bruceantinoside A
Bruceantinoside A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Bruceantinoside A
Price:
CAS No.: 79439-85-3
Catalog No.: CFN89343
Molecular Formula: C34H46O16
Molecular Weight: 710.71 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The fruits of Brucea javanica.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Bruceantinoside A has antileukemic activity.
In vitro:
Phytother Res. 2011 Dec;25(12):1796-800.
Seven quassinoids from Fructus Bruceae with cytotoxic effects on pancreatic adenocarcinoma cell lines.[Pubmed: 21480411]
Our previous studies showed that the alcohol extract of the fruit of Brucea javanica (Fructus Bruceae) possessed significant cytotoxicity in pancreatic adenocarcinoma cell lines.
METHODS AND RESULTS:
A bioassay-guided fractionation and purification resulted in the isolation and characterization of seven quassinoids including brusatol, bruceine D, bruceine H, yadanzioside A, yadanzioside G, javanicoside C and Bruceantinoside A. Among them, brusatol exhibited the most potent in vitro antipancreatic cancer action, with IC(50) values of 0.36 μm and 0.10 μm on PANC-1 and SW1990 cell lines, respectively.
CONCLUSIONS:
This is the first report on the antipancreatic adenocarcinoma activity of brusatol.
Bruceantinoside A Description
Source: The fruits of Brucea javanica.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.407 mL 7.0352 mL 14.0704 mL 28.1409 mL 35.1761 mL
5 mM 0.2814 mL 1.407 mL 2.8141 mL 5.6282 mL 7.0352 mL
10 mM 0.1407 mL 0.7035 mL 1.407 mL 2.8141 mL 3.5176 mL
50 mM 0.0281 mL 0.1407 mL 0.2814 mL 0.5628 mL 0.7035 mL
100 mM 0.0141 mL 0.0704 mL 0.1407 mL 0.2814 mL 0.3518 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Nat Prod. 1981 Jul-Aug;44(4):470-4.
Antitumor agents. 39. Bruceantinoside-A and -B, novel antileukemic quassinoid glucosides from Brucea antidysenterica.[Reference: WebLink]

METHODS AND RESULTS:
The new antileukemic quassinoid glucosides Bruceantinoside A (1) and bruceantinoside B (2) were isolated from Brucea antidysenterica.
CONCLUSIONS:
The structure of 1 and 2 has been established from chemical transformation, correlations and spectral analyses, especially the 13C-nmr spectral data.
CFN89342Dehydrobruceantinol99132-99-7604.59C30H36O13
CFN89343Bruceantinoside A79439-85-3710.71C34H46O16
CFN96423Yadanzioside F95258-11-0642.60C29H38O16
CFN95080Bruceoside A63306-30-9682.7C32H42O16
CFN96425Yadanzioside A95258-15-4684.68C32H44O16
CFN96424Yadanzioside C95258-16-5726.72C34H46O17
CFN96422Yadanzioside G95258-17-6768.76C36H48O18
CFN89337Dehydrobruceantin53662-98-9546.56C28H34O11
CFN96418Yadanzioside M101559-99-3704.67C34H40O16
CFN97461Picrasinol B89498-91-9392.5 C22H32O6
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