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Brugine
Brugine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Brugine
Price:
CAS No.: 14912-30-2
Catalog No.: CFN00181
Molecular Formula: C12H19NO2S2
Molecular Weight: 273.42 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Oil
Source: The barks of Bruguiera sexangula.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Brugine is a natural product from Bruguiera sexangula.
Brugine Description
Source: The barks of Bruguiera sexangula.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.6574 mL 18.2869 mL 36.5738 mL 73.1475 mL 91.4344 mL
5 mM 0.7315 mL 3.6574 mL 7.3148 mL 14.6295 mL 18.2869 mL
10 mM 0.3657 mL 1.8287 mL 3.6574 mL 7.3148 mL 9.1434 mL
50 mM 0.0731 mL 0.3657 mL 0.7315 mL 1.463 mL 1.8287 mL
100 mM 0.0366 mL 0.1829 mL 0.3657 mL 0.7315 mL 0.9143 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Australian Journal of Chemistry,1969, 22(6) 1271 - 1275
Tumour inhibitory plants. The alkaloids of Bruguiera sexangula and Bruguiera exaristata (Rhizophoraceae)[Reference: WebLink]

METHODS AND RESULTS:
Tropine and tropine esters of acetic, propionic (a new natural ester), n-butyric (a new natural ester), isobutyric, α-methylbutyric or isovaleric, and benzoic acids have been identified in crude alkaloid mixtures from the bark of B. sexangula and B. exaristata.
CONCLUSIONS:
The major component of the mixtures from both species was a new alkaloid, Brugine, (+)-tropine 1,2-dithiolan-3-carboxylate.
CFN00148Anisodine52646-92-1319.36C17H21NO5
CFN00149Apoatropine500-55-0271.36C17H21NO2
CFN00150Apohyoscine535-26-2285.34C17H19NO3
CFN00151Aponorhyoscine25650-56-0271.31C16H17NO3
CFN00171Nortropacocaine18470-33-2231.29C14H17NO2
CFN00177Bellendine32152-73-1205.26C12H15NO2
CFN00181Brugine14912-30-2273.42C12H19NO2S2
CFN00182Chalcostrobamine75638-72-1269.34C17H19NO2
CFN00183Cocaine50-36-2303.35C17H21NO4
CFN00184Pseudococaine478-73-9303.35C17H21NO4
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