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Caesalmin E
Caesalmin E
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Caesalmin E
Price:
CAS No.: 204185-91-1
Catalog No.: CFN96944
Molecular Formula: C26H36O9
Molecular Weight: 492.56 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The seed kernels of Caesalpinia crista.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Caesalmin E shows anti-Para3 virus activity.
Targets: Antifection
In vitro:
J Nat Prod. 2001 Oct;64(10):1266-72.
New antiviral cassane furanoditerpenes from Caesalpinia minax.[Pubmed: 11678648]
A bioassay-guided study led to the isolation of five new cassane furanoditerpenes, designated as caesalmin C (1), caesalmin D (2), Caesalmin E (3), caesalmin F (4), and caesalmin G (5), along with stigmasterol (6) from the seeds of Caesalpinia minax.
METHODS AND RESULTS:
The (1)H and (13)C NMR spectra were completely assigned by using a combination of 2D NMR analyses. The structures of all five furanoditerpenes were confirmed by X-ray analyses. The structure of 6 was verified by X-ray analysis for the first time.
CONCLUSIONS:
The bioassay results showed that the anti-Para3 virus activity of tetracyclic furanoditerpenoids 1-4 is more potent than that of the furanoditerpenoid lactone 5, which is in turn better than 6. As the major components of the plant possess significant potent activity, it may be feasible to develop new antiviral agents from this source.
Caesalmin E Description
Source: The seed kernels of Caesalpinia crista.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.0302 mL 10.151 mL 20.3021 mL 40.6042 mL 50.7552 mL
5 mM 0.406 mL 2.0302 mL 4.0604 mL 8.1208 mL 10.151 mL
10 mM 0.203 mL 1.0151 mL 2.0302 mL 4.0604 mL 5.0755 mL
50 mM 0.0406 mL 0.203 mL 0.406 mL 0.8121 mL 1.0151 mL
100 mM 0.0203 mL 0.1015 mL 0.203 mL 0.406 mL 0.5076 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Nat Prod. 2004 Nov;67(11):1859-63.
Cassane- and norcassane-type diterpenes of Caesalpinia crista from Myanmar.[Pubmed: 15568776]

METHODS AND RESULTS:
From the CH(2)Cl(2) extract of seed kernels of Caesalpinia crista from Myanmar, five new cassane-type diterpenes, caesalpinins MA-ME (1-5), and three new norcassane-type diterpenes, norcaesalpinins MA-MC (6-8), have been isolated, together with 12 known cassane-type diterpenes, 14(17)-dehydrocaesalmin F, caesaldekarin e, caesalmin B, caesalmin C, Caesalmin E, 2-acetoxy-3-deacetoxycaesaldekarin e, 2-acetoxycaesaldekarin e, caesalpinin C, 7-acetoxybonducellpin C, caesalpinin E, norcaesalpinin B, and 6-acetoxy-3-deacetoxycaesaldekarin e.
CONCLUSIONS:
The structures of the isolated compounds were elucidated by analysis of their spectroscopic data.
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