Science | Nature | Cell | View More
Natural Products
Cassiaside B2
Cassiaside B2
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Cassiaside B2
Price: $338 / 5mg
CAS No.: 218155-40-9
Catalog No.: CFN91134
Molecular Formula: C39H52O25
Molecular Weight: 920.8 g/mol
Purity: >98%
Type of Compound: Phenols
Physical Desc.: Powder
Source: The seeds of Cassia obtusifolia L.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $521.5 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Universidade Católica Portuguesa (Portugal)
  • Ain Shams University (Egypt)
  • University of Illinois at Chicago (USA)
  • University of British Columbia (Canada)
  • University of Fribourg (Switzerland)
  • Seoul National University of Sc... (Korea)
  • Tokyo Woman's Christian University (Japan)
  • Deutsches Krebsforschungszentrum (Germany)
  • University of Virginia (USA)
  • Griffith University (Australia)
  • Instytut Nawozów Sztucznych w ... (Poland)
  • More...
Package
Featured Products
Magnoflorine

Catalog No: CFN98071
CAS No: 2141-09-5
Price: $98/20mg
Kukoamine A

Catalog No: CFN93215
CAS No: 75288-96-9
Price: $ / mg
Sophoricoside

Catalog No: CFN90148
CAS No: 152-95-4
Price: $40/20mg
1,5-Dicaffeoylquinic acid

Catalog No: CFN90937
CAS No: 19870-46-3
Price: $138/20mg
Asiaticoside B

Catalog No: CFN95124
CAS No: 125265-68-1
Price: $158/20mg
Citropten

Catalog No: CFN97963
CAS No: 487-06-9
Price: $60/20mg
L-Arginine

Catalog No: CFN90550
CAS No: 74-79-3
Price: $30/20mg
Alpha-pinene

Catalog No: CFN93285
CAS No: 80-56-8
Price: $30/20mg
Guanosine

Catalog No: CFN90925
CAS No: 118-00-3
Price: $30/20mg
Candicine

Catalog No: CFN91816
CAS No: 6656-13-9
Price: $ / mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Reference standards.
In vitro:
ACS Omega. 2019 Jul 3;4(7):11621-11630.
Rubrofusarin as a Dual Protein Tyrosine Phosphate 1B and Human Monoamine Oxidase-A Inhibitor: An in Vitro and in Silico Study.[Pubmed: 31460269]
A number of nature-derived biologically active compounds comprise glycosides. In some cases, the glycosidic residue is needed for bioactivity; however, in other cases, glycosylation just improves some pharmacokinetic/dynamic parameters. The patterns of protein tyrosine phosphatase 1B (PTP1B) and human monoamine oxidase A (hMAO-A) inhibition by rubrofusarin 6-O-β-d-glucopyranoside (1), rubrofusarin 6-O-β-d-gentiobioside (2), rubrofusarin triglucoside (3), and Cassiaside B2 (4) were compared with the aglycone, rubrofusarin, isolated from Cassia obtusifolia seeds.
METHODS AND RESULTS:
Rubrofusarin showed potent inhibition against the PTP1B enzyme (IC50; 16.95 ± 0.49 μM), and its glycosides reduced activity (IC50; 87.36 ± 1.08 μM for 1 and >100 μM for 2-4) than did the reference drug, ursolic acid (IC50; 2.29 ± 0.04 μM). Similarly, in hMAO-A inhibition, rubrofusarin displayed the most potent activity with an IC50 value of 5.90 ± 0.99 μM, which was twice better than the reference drug, deprenyl HCl (IC50; 10.23 ± 0.82 μM). An enzyme kinetic and molecular docking study revealed rubrofusarin to be a mixed-competitive inhibitor of both these enzymes. In a western blot analysis, rubrofusarin increased glucose uptake significantly and decreased the PTP1B expression in a dose-dependent manner in insulin-resistant HepG2 cells, increased the expression of phosphorylated protein kinase B (p-Akt) and phosphorylated insulin receptor substrate-1 (p-IRS1) (Tyr 895), and decreased the expression of glucose-6-phosphatase (G6Pase) and phosphoenol pyruvate carboxykinase (PEPCK), key enzymes of gluconeogenesis.
CONCLUSIONS:
Our overall results show that glycosylation retards activity; however, it reduces toxicity. Thus, Cassia seed as functional food and rubrofusarin as a base can be used for the development of therapeutic agents against comorbid diabetes and depression.
Cassiaside B2 Description
Source: The seeds of Cassia obtusifolia L.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Ginsenoside Rd2 (Quinquenoside L10...

Catalog No: CFN95231
CAS No: 83480-64-2
Price: $318/10mg
Isocucurbitacin D

Catalog No: CFN95326
CAS No: 68422-20-8
Price: $318/5mg
1,3,6-Trihydroxy-2-methylanthraqui...

Catalog No: CFN95095
CAS No: 87686-87-1
Price: $218/10mg
Cannabiscitrin

Catalog No: CFN95278
CAS No: 520-14-9
Price: $318/5mg
3,7,23,24-tetrahydroxycucurbita-5,...

Catalog No: CFN95168
CAS No: 1446447-97-7
Price: $318/5mg
Lappaol B

Catalog No: CFN95242
CAS No: 62359-60-8
Price: $333/10mg
Quercetin-3'-glucoside

Catalog No: CFN95271
CAS No: 19254-30-9
Price: $318/10mg
3',8-Dihydroxyvestitol

Catalog No: CFN95384
CAS No: 122587-87-5
Price: $413/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.086 mL 5.4301 mL 10.8601 mL 21.7202 mL 27.1503 mL
5 mM 0.2172 mL 1.086 mL 2.172 mL 4.344 mL 5.4301 mL
10 mM 0.1086 mL 0.543 mL 1.086 mL 2.172 mL 2.715 mL
50 mM 0.0217 mL 0.1086 mL 0.2172 mL 0.4344 mL 0.543 mL
100 mM 0.0109 mL 0.0543 mL 0.1086 mL 0.2172 mL 0.2715 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Zhongguo Zhong Yao Za Zhi. 2017 Sep;42(17):3385-3390.
Study on naphthopyrone reference extract and application on assay of Semen Cassiae.[Pubmed: 29192451 ]
A quality control method of Semen Cassiae was established by using naphthopyrone reference extract(NRE). Meanwhile, the feasibility about NRE replacing single component reference in quality control of traditional Chinese medicine was explored.
METHODS AND RESULTS:
After NRE of Semen Cassiae being prepared by chromatographic separation technology, we determined the three main components, Cassiaside B2, rubrofusarin-6-O-β-D-gentiobioside and cassiaside C. In the meantime, an HPLC analytical method, based on the NRE as standard substance, was developed to determinate the contents of three main components in Semen Cassiae. T-test was used for comparison of the determination results of the two methods(single chemical component and NRE as reference substances, respectively), and the T-test result demonstrated that there was no significant difference between the two methods.
CONCLUSIONS:
The results developed scientific basis for the application of NRE of Semen Cassia in the quality control, which could be applied for the quality control of traditional Chinese medicine using reference extract substituting single chemical reference, and provide a new research model for the quality control of Chinese medicine.
Magnoflorine

Catalog No: CFN98071
CAS No: 2141-09-5
Price: $98/20mg
Kukoamine A

Catalog No: CFN93215
CAS No: 75288-96-9
Price: $ / mg
Sophoricoside

Catalog No: CFN90148
CAS No: 152-95-4
Price: $40/20mg
1,5-Dicaffeoylquinic acid

Catalog No: CFN90937
CAS No: 19870-46-3
Price: $138/20mg
Asiaticoside B

Catalog No: CFN95124
CAS No: 125265-68-1
Price: $158/20mg
Citropten

Catalog No: CFN97963
CAS No: 487-06-9
Price: $60/20mg
L-Arginine

Catalog No: CFN90550
CAS No: 74-79-3
Price: $30/20mg
Alpha-pinene

Catalog No: CFN93285
CAS No: 80-56-8
Price: $30/20mg
Guanosine

Catalog No: CFN90925
CAS No: 118-00-3
Price: $30/20mg
Candicine

Catalog No: CFN91816
CAS No: 6656-13-9
Price: $ / mg
Tags: buy Cassiaside B2 | Cassiaside B2 supplier | purchase Cassiaside B2 | Cassiaside B2 cost | Cassiaside B2 manufacturer | order Cassiaside B2 | Cassiaside B2 distributor