Catechin 7-xyloside | CAS:42830-48-8 | Manufacturer ChemFaces

Catechin 7-xyloside

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Catechin-7-O-xyloside has anti-cancer activity, it induces apoptosis via endoplasmic reticulum stress and mitochondrial dysfunction in human non-small cell lung carcinoma H1299 cells.

In vitro:

Oncol. Rep., 2014, 31(1):314-20.

Catechin-7-O-xyloside induces apoptosis via endoplasmic reticulum stress and mitochondrial dysfunction in human non-small cell lung carcinoma H1299 cells.[Pubmed: 24213951]

The medicinal plant Ulmus davidiana var. japonica has significant potential as a cancer chemoprevention agent. Catechin 7-O-xyloside (Catechin 7-xyloside,C7Ox) was purified from ultrafine U. davidiana var. japonica ethanol extract.
METHODS AND RESULTS:
In the present study, we investigated the apoptotic effect of C7Ox in the non-small cell lung cancer (NSCLC) cell line H1299. C7Ox treatment induced cell death and decreased plasma membrane integrity, an event typical of apoptosis. C7Ox-induced apoptosis was associated with the proteolytic activation of caspase-6, cleavage of poly(ADP-ribose) polymerase (PARP) and loss of mitochondrial membrane potential. C7Ox also induced the endoplasmic reticulum (ER) stress-regulated pro-apoptotic transcription factor CHOP. The suppression of CHOP expression significantly decreased C7Ox-induced cell death, LDH leakage and caspase-6 activation. Antitumor effects, evaluated based on protracted tumor regression, were observed when nude-mice bearing H1299 xenografts were treated with C7Ox. C7Ox-induced tumor regression was accompanied by enhanced expression of CHOP mRNA.
CONCLUSIONS:
Our data suggest that C7Ox can trigger mitochondrial-mediated apoptosis, and that ER stress is critical for C7Ox-induced apoptosis in H1299 NSCLC cells.

Catechin 7-xyloside Description

Source:	The herbs of Spiraea hypericifolia L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Catechin 7-xyloside
Price:
CAS No.:	42830-48-8
Catalog No.:	CFN98665
Molecular Formula:	C₂₀H₂₂O₁₀
Molecular Weight:	422.4 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The herbs of Spiraea hypericifolia L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3674 mL	11.8371 mL	23.6742 mL	47.3485 mL	59.1856 mL
5 mM	0.4735 mL	2.3674 mL	4.7348 mL	9.4697 mL	11.8371 mL
10 mM	0.2367 mL	1.1837 mL	2.3674 mL	4.7348 mL	5.9186 mL
50 mM	0.0473 mL	0.2367 mL	0.4735 mL	0.947 mL	1.1837 mL
100 mM	0.0237 mL	0.1184 mL	0.2367 mL	0.4735 mL	0.5919 mL

CFN92954	5,7,4'-Trimethoxyafzelechin	918428-88-3	316.35	C₁₈H₂₀O₅
CFN96042	5,7,4'-Tri-O-methylcatechin	105330-59-4	332.4	C₁₈H₂₀O₆
CFN99138	(+)-Gallocatechin	970-73-0	306.27	C₁₅H₁₄O₇
CFN89499	Afzelechin 3-O-xyloside	512781-45-2	406.38	C₂₀H₂₂O₉
CFN98617	3,4,4',7-Tetrahydroxyflavan	38412-82-7	274.3	C₁₅H₁₄O₅
CFN99646	Catechin	154-23-4	290.3	C₁₅H₁₄O₆
CFN99568	(+)-Catechin hydrate	7295-85-4	308.28	C₁₅H₁₄O₆.H₂O
CFN99682	Catechin pentaacetate	16198-01-9	500.5	C₂₅H₂₄O₁₁
CFN98665	Catechin 7-xyloside	42830-48-8	422.4	C₂₀H₂₂O₁₀
CFN95524	Catechin 7-O-beta-D-glucopyranoside	65597-47-9	452.4	C₂₁H₂₄O₁₁